Method for the treatment of retinal detachments

• US 5,336,175 A
• Filed: 10/29/1992
• Issued: 08/09/1994
• Est. Priority Date: 10/29/1992
• Status: Expired due to Fees

• Current Assignee: Robert N. Mames
• Original Assignee: Robert N. Mames
• Inventors: Mames, Robert N.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Rafa, Michael
• Application Number:
  US07/968,586
• Time in Patent Office: 649 Days
• Field of Search: 604/23, 604/26, 604/49, 128/898
• US Class Current: 604/521
• CPC Class Codes: A61F 9/00727 Apparatus for retinal reattachment
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears

Abstract

One of the aspects of the present invention relates to a method for the treatment of retinal detachments utilizing a transparent liquid or gel retina reattachment enhancing material preferably perfluorotri-n-propylamine for long-term but not permanent replacement in the eye for effecting a retinal reattachment of a retinal tear. A sufficient amount of a gas is first injected into the vitreous cavity of a patient'"'"'s eye having a first gel or liquid material therein and a retinal tear so that the gas expands, compresses, and displaces an amount of the first gel or liquid to provide a space for receipt of a sufficient amount of the retina reattachment enhancing material. Once sufficient space is provided in the vitreous cavity, the retina reattachment enhancing material is injected into the eye. Once the retinal tear is visible and lies flat upon the underlying tissue, the retina is tacked down around the retinal tear so as to form a retinal scar. The enhancing material is left in the eye until the retinal tear is fixedly reattached to the underlying tissue. The enhancing material which is preferably a liquid perfluorocarbon material should not remain indefinitely in the eye and is removed and replaced with a replacement material that can be left in the eye indefinitely. Outpatient procedures are emphasized.

Claims

1. A method for the treatment of retinal detachments including the steps of:

inserting into a vitreous cavity of an eye of a patient having a first gel or liquid therein and a retinal tear a sufficient amount of a transparent liquid or gel retina reattachment enhancing material, such that when said patient is in a position which allows said retina reattachment enhancing material to contact the region of said retinal tear, it presses said retinal tear against an underlying layer of tissue so as to effect retinal reattachment over a given period of time;

leaving said retina reattachment enhancing material in said eye for at least one or more days wherein said patient is in said position during at least said period of time; and

,

after said retinal tear has become fixedly reattached to said underlying layer of tissue, selectively removing said retina reattachment enhancing material from said eye and replacing said retina reattachment enhancing material with a replacement material which can remain indefinitely in said eye.

2. The method of claim 1 wherein said insertion of said retina reattachment enhancing material is inserted outside of an operating room without removal of said first gel or liquid.

3. The method of claim 1 wherein said insertion of said retina reattachment enhancing material is conducted in an operating room where there is also effected at least partial removal of a vitreous gel so as to provide a space for receipt of said retina reattachment enhancing material.

4. The method of claim 3 wherein said at least partially removed vitreous gel is replaced by a balanced saline solution prior to insertion of said retina reattachment enhancing material.

5. The method of claim 1 wherein said retina reattachment enhancing material is a liquid perfluorocarbon material or a derivative thereof.

6. The method of claim 5 wherein said liquid perfluorocarbon material or said derivative thereof is a perfluoroalkyl amine material or its derivative.

7. The method of claim 6 wherein said liquid perfluorocarbon material or said derivative thereof is a perfluoroalkyl amine material or its derivative with about 5 or less carbon atoms in the alkyl radical involved.

8. The method of claim 7 wherein said liquid perfluorocarbon material or said derivative thereof is perfluorotri-n-propylamine or a derivative thereof.

9. The method of claim 1 wherein said replacement material which can remain indefinitely in said eye is selected from the group comprising a balanced salt solution, sterile air, gas or a derivative of methylcellulose.

10. The method of claim 1 wherein said vitreous cavity has a first liquid or gel material in said vitreous cavity when said method is initiated, and at least one day before insertion into said vitreous cavity of said retina reattachment enhancing material, a gas in injected therein, said gas expanding against said first material and providing a space for reception of said retina reattachment enhancing material.

11. The method of claim 1 wherein removal of said liquid or gel retina reattachment enhancing material is outside of an operating room.

12. The method of claim 1 including the step of tacking said retina in a substantially permanent manner down around said retinal tear so as to form a retinal scar, after said retinal tear is visible and said retinal tear lies flat upon said underlying tissue as a result of said insertion of said retina reattachment enhancing material.

13. The method of claim 12 wherein said tacking step comprises treating said retina with a treatment selected from the group consisting of laser photocoagulation or cryotherapy.

14. The method of claim 1 wherein said position of said patient is a supine position.

15. A method for the treatment of retinal detachments conducted outside of an operating room, comprising the steps of:

inserting into a vitreous cavity of an eye of a patient having a retinal tear in an anterior region of said vitreous cavity, said vitreous cavity having a first gel or liquid material therein, a transparent liquid perfluorocarbon material or a derivative thereof, having a specific gravity greater than said first gel or liquid material and being of a sufficient volume such that said liquid perfluorocarbon material will contact and press said retinal tear when said patient is in a position which allows said liquid perfluorocarbon material to contact said region of said retinal tear over at least a given period of time to effect retinal reattachment, said liquid perfluorocarbon material dropping to a bottom portion of said first gel or liquid material and pressing said retinal tear against an underlying layer of tissue adjacent sad vitreous cavity when said patient is in said position;

leaving said liquid perfluorocarbon material or said derivative thereof in said eye for one or more days during at least part of which time said patient is in said position for at least said given period of time where said retina will become fixedly reattached to said underlying layer of tissue; and

,

after said retina becomes fixedly attached to said underlying layer of tissue, selectively removing said liquid perfluorocarbon material from said eye and replacing it with a material which can remain indefinitely in said eye.

16. The method of claim 15 including the step of tacking said retina in a substantially permanent manner down around said retinal tear so as to form a retinal scar, after said retinal tear is visible and said retinal tear lies flat upon said underlying tissue as a result of said insertion of said liquid perfluorocarbon material.

17. The method of claim 15 wherein said position of said patient is a supine position.

18. A method for the treatment of retinal detachments conducted outside of an operating room comprising the steps of:

injecting at least once a sufficient amount of a gas into a vitreous cavity of a patient'"'"'s eye, said vitreous cavity having a first gel or liquid material therein and a retinal tear in a given region thereof, such that said gas expands in said vitreous cavity and compresses and displaces a sufficient amount of said first gel or liquid material to provide a space for receipt of a sufficient amount of a transparent liquid or gel retina reattachment enhancing material, so that said retinal tear is reattached without permanent damage to the eye when said retina reattachment enhancing material contacts said retinal tear for a given period of time;

leaving said gas in said eye at least for one or more days to provide said contact for said given period of time;

injecting said sufficient amount of said retina reattachment enhancing material into said vitreous cavity of said eye and moving said gas from said eye; and

,

leaving said retina reattachment enhancing material in said eye or at least said given period of time while said patient is in a given position which allows said retina reattachment enhancing material to contact said region of said retinal tear for at least said given period of time so that said retinal tear becomes fixedly reattached to an underlying tissue.

19. The method of claim 18 including the step of selectively removing said retina reattachment enhancing material after said retina becomes fixedly attached to said underlying tissue and replacing it with a material which can remain indefinitely in the eye.

20. The method of claim 19 wherein said material which can remain indefinitely in the eye is selected from the group comprising a balanced salt solution, sterile air, a gas or a methylcellulose derivative.

21. The method of claim 18 wherein said retina reattachment enhancing material is a liquid perfluorocarbon material or a derivative thereof having a specific gravity greater than said first material.

22. The method of claim 21 wherein said liquid perfluorocarbon material or said derivative thereof is a perfluoroalkyl amine material or a derivative thereof.

23. The method of claim 22 wherein said liquid perfluorocarbon material or said derivative thereof is a perfluoroalkyl amine material or its derivative with less than about 5 carbon atoms in the alkyl radical involved.

24. The method of claim 23 wherein said liquid perfluorocarbon material or said derivative thereof is perfluorotri-n-propylamine or a derivative thereof.

25. The method of claim 18 wherein said retina reattachment enhancing material is retained in said eye for at least one day wherein said patient has left the situs of said retina reattachment enhancing material insertion and has assumed said given position for at least said given period of time.

26. The method of claim 18 wherein said first material is a vitreous gel and said retina reattachment enhancing material is inserted into said eye with said vitreous gel being present.

27. The method of claim 18 wherein said first material is a salt solution injected during a previous surgical procedure to replace a vitreous gel.

28. The method of claim 18 including the step of tacking said retina in a substantially permanent manner down around said retinal tear so as to form a retinal scar, after said retinal tear is visible and said retinal tear lies flat upon said underlying tissue as a result of said injection of said retina reattachment enhancing material.

29. The method of claim 28 wherein said tacking step comprises treating said retina with a treatment selected from the group consisting of laser photocoagulation or cryotherapy.

30. The method of claim 18 wherein said position of said patient is a supine position.

31. A method for the treatment of retinal detachments conducted outside of an operating room, comprising the steps of:

injecting into a vitreous cavity of a patient'"'"'s eye having a retinal tear and a first liquid or gel material therein a sufficient amount of a derivative of methylcellulose to effect retinal reattachment when said methylcellulose derivative contacts a region of said retinal tear for a given period of time; and

,

leaving said derivative of methylcellulose derivative in said eye indefinitely.

32. The method of claim 31 wherein prior to said injection of said methylcellulose derivative, a sufficient amount of gas is injected into said vitreous cavity for a given period of time, said gas expanding in said vitreous cavity and compressing and displacing a sufficient amount of said first gel or liquid material to provide a space for receipt of a sufficient amount of a vitreous substitute material to effect reattachment of the retina.

33. The method of claim 31 including the step of tacking said retina in a substantially permanent manner down around said retinal tear so as to form a retinal scar, after said retinal tear is sealed and visible and said retina lies flat upon an underlying layer of tissue.

34. The method of claim 33 wherein said tacking step comprises treating said retina with a treatment selected from the group consisting of laser photocoagulation or cryotherapy.