Selectable dosage transdermal delivery system
First Claim
1. A transdermal drug delivery system, comprising a laminate composite of:
- (a) a first permeable membrane to be placed in contact with a patient'"'"'s skin;
(b) a transfer gel layer disposed on said first permeable membrane;
(c) a second permeable membrane disposed on said transfer gel layer;
(d) a reservoir structure disposed above said second permeable membrane, said reservoir structure having a plurality of drug reservoirs formed therein for receiving medicament;
(e) activation means for releasing medicament from said drug reservoirs for contact with the skin of the patient;
said activation means comprising a dial rotatably supported on said reservoir structure, and puncture pins supported in said dial.
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Accused Products
Abstract
A transdermal drug delivery system is disclosed. The system comprises a laminate composite of a patch/skin permeable membrane; a transfer gel layer disposed on said permeable membrane; a permeable membrane disposed on said transfer gel layer; a plurality of sectional drug reservoirs for receiving medicament disposed on the transfer gel layer; and activation means for releasing medicament from said drug reservoirs for contact with skin of a patient. The medicament in contained in the reservoirs at varying amounts and/or concentrations, providing for selectable dosage, for sequential delivery, for sequential activation, for variable unit dose drug delivery in transdermal application.
84 Citations
22 Claims
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1. A transdermal drug delivery system, comprising a laminate composite of:
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(a) a first permeable membrane to be placed in contact with a patient'"'"'s skin; (b) a transfer gel layer disposed on said first permeable membrane; (c) a second permeable membrane disposed on said transfer gel layer; (d) a reservoir structure disposed above said second permeable membrane, said reservoir structure having a plurality of drug reservoirs formed therein for receiving medicament; (e) activation means for releasing medicament from said drug reservoirs for contact with the skin of the patient;
said activation means comprising a dial rotatably supported on said reservoir structure, and puncture pins supported in said dial. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 13, 14, 15)
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12. A transdermal drug delivery system, comprising a laminate composite of:
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a first permeable membrane to be placed in contact with a patient'"'"'s skin; a transfer gel layer disposed on said first permeable membrane; a second permeable membrane disposed on said transfer gel layer; a reservoir structure disposed above said second permeable membrane, said reservoir structure having a plurality of drug reservoirs formed therein for receiving medicament, wherein said reservoir structure with said drug reservoirs includes; (a) an impervious lower layer having a plurality of windows formed therein, said windows comprising seal means to be punctured for releasing medicament from a respective drug reservoir for contact with the skin of the patient; (b) an impervious upper layer disposed above said lower layer and having channels formed therein for receiving puncture pins and having a plurality of windows formed therein, said windows formed in said upper layer being aligned with said windows formed in said lower layer; and activation means for releasing medicament from said drug reservoirs for contact with the skin of the patient. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22)
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Specification