Inhibitor for delta 5-desaturase

• US 5,336,496 A
• Filed: 04/14/1992
• Issued: 08/09/1994
• Est. Priority Date: 03/07/1989
• Status: Expired due to Term

• Current Assignee: Suntory Holdings Limited (Kotobuki Realty Co., Ltd.)
• Original Assignee: Suntory Ltd (Kotobuki Realty Co., Ltd.)
• Inventors: Akimoto, Kengo, Shimizu, Sakayu, Yamada, Hideaki, Sugano, Michihiro, Shinmen, Yoshifumi
• Primary Examiner(s): Wityshyn, Michael G.
• Assistant Examiner(s): GITOMER, RALPH J
• Application Number:
  US07/867,086
• Time in Patent Office: 847 Days
• Field of Search: 424/195.1, 514/80, 514/783, 514/885
• US Class Current: 514/464
• CPC Class Codes: A61K 31/12 Ketones
• CPC Class Codes: A61K 31/34 having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
• CPC Class Codes: A61K 31/36 Compounds containing methylenedioxyphenyl groups, e.g. sesamin
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: A61P 9/12 Antihypertensives

Abstract

A composition for inhibiting Δ⁵ -desaturase comprising an effective ingredient selected from the group consisting of lignan compounds, curcumin and piperonyl butoxide. As the lignan compounds sesamin, sesaminol, episesamin, episesaminol, sesamolin, 2-(3,4-methylenedioxyphenyl)-6-(3-methoxy-4 -hydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane, 2,6-bis-(3-methoxy-4-hydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane, and 2-(3,4-methylenedioxyphenyl)-6 -(3-methoxy-4-hydroxyphenoxy)-3,7-dioxabicyclo[3.3.0]-octane are used. Moreover the effective ingredient may be a sesame oil extract or sesame seed extract.

Claims

1. A method for inhibiting Δ

⁵ -desaturase in an animal which is in need of Δ

⁵ -desaturase inhibition, which method comprises administering to said animal in need of Δ

⁵ -desaturase inhibition at least a Δ

⁵ -desaturase inhibitory amount of at least one compound selected from the group consisting of sesamin, sesaminol, episesamin, episesaminol, sesamolin, 2-(3,4-methylenedioxyphenyl) -6-(3-methoxy-4-hydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane, 2,6-bis-(3-methoxy-4-hydroxyphenyl)-3,7-dioxabicyclo[3.3.0]-octane,2-(3,4-methylenedioxyphenyl)-6-(3-methoxy-4-hydroxyphenoxy)-3,7-dioxabicyclo[3.3.0]octane, and piperonyl butoxide.

4. The method of claim 1, wherein the inhibition of Δ

⁵ -desaturase results in treatment of inflammation, thrombosis or hypertension.

2. A method for inhibiting Δ

⁵ -desaturase in an animal which is in need of Δ

⁵ -desaturase inhibition which method comprises administering to said animal in need of Δ

⁵ -desaturase inhibition at least a Δ

⁵ -desaturase inhibitory amount of an extract of sesame seeds or sesame oil wherein the extract has been prepared using an organic solvent selected from the group consisting of acetone, methyl ethyl ketone, diethyl ketone, methanol and ethanol.

3. A method for inhibiting Δ

⁵ -desaturase in an animal suffering from hypertension or thrombus, which method comprises administering to said animal at least a Δ

⁵ -desaturase inhibitory amount of curcumin.