Implantable device for estimating glucose levels

• US 5,337,747 A
• Filed: 01/07/1993
• Issued: 08/16/1994
• Est. Priority Date: 10/06/1989
• Status: Expired due to Fees

• Current Assignee: Frederic Neftel
• Original Assignee: Frederic Neftel
• Inventors: Neftel, Frederic
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): NASSER, ROBERT L
• Application Number:
  US08/001,433
• Time in Patent Office: 586 Days
• Field of Search: 204/403, 204/415, 128/635, 128/632, 128/637, 128/746, 128/750, 604/65-67
• US Class Current: 600/347
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement

Abstract

An implantable device which comprises two measurement chambers each of which comprises an internal measurement chamber insulated from its surroundings by a glucose-hemipermeable membrane for the first measurement chamber, and by a glucose-permeable membrane which is impermeable to molecules larger than glucose for the second measurement chamber, connected to a pressure sensor for each of the measurement chambers, and linked to an electronic system provided for informing the environment outside the organism of the value of the pressure measured in each of the two measurement chambers and, therefore, of the glucose level.

Claims

1. An implantable device for estimating the glucose level by measuring the osmotic pressure due to glucose, characterized in that it comprises:

a first measuring chamber insulated from the surrounding medium by a first glucose-hemipermeable membrane, said first chamber cooperating with a first pressure sensor, which in turn is connected to an electronic system for transmitting information pertaining to the value of a measured pressure,

a second measuring chamber insulated from the surrounding medium by a second membrane permeable to glucose and non-permeable to molecules larger than glucose, this second chamber cooperating with a second pressure sensor, which in turn is connected to an electronic system for transmitting information pertaining to the value of the measured pressure, and

means associated with said first and second pressure sensors for providing through the difference between the measured pressures, an accurate estimation of the osmotic pressure due solely to glucose and, consequently, of the glucose level.

2. A device according to claim 1, characterized in that the first membrance is stiffened by a third perforated membrane of a low elasticity, in order to reduce the dampening of the pressure prevailing inside the first measuring chamber by the first membrane and, therefore, to optimize the yield of the first pressure sensor.

3. A device according to claim 2, characterized in that the third perforated membrane is produced by photolithographic techniques.

4. A device according to claim 1, characterized in that the first pressure sensor is made of photolithographically machined silicon.

5. A device according to claim 1, characterized in that the electronic system connected to the first pressure sensor is a LC-type resonant passive system, the resonance frequency of which varies as a function of the pressure which is measured, the value of this pressure being determined by a magnetically coupled variable oscillator.

6. A device according to claim 1, characterized in that each of the measuring chambers contains macromolecules, the concentration of which is selected according to the values of the osmotic pressures which are to be measured and to the optimal operational range of the first and second pressure sensors.

7. A device according to claim 1, characterized in that the first membrane is in turn protected from the outside medium in which the device is implanted by a fourth biocompatible membrane which is non-permeable to cells but permeable at least to glucose and water.

8. A device according to claim 1, characterized in that the device is adapted to be implanted into subcutaneous tissue.

9. A device according to claim 1, characterized in that it includes means for automatically transmitting the results of the measurements to an insulin micropump to enable the administration of a desired amount of insulin so that the assembly functions as a substitute for the normal pancreatic functions of the patient.

10. A device according to claim 1, characterized in that the means for providing an estimation of glucose levels includes means to take into account variations of such levels over time, by comparison with a data base established for a value or for known variations of the blood glucose level, this data base optionally being re-established at regular intervals of time of operation, depending on the nature of the selected hemi-permeable membrane or on the patient.

11. An implantable device for estimating the glucose level by measuring the osmotic pressure due to glucose, characterized in that it comprises:

a first measuring chamber insulated from the surrounding medium by a first glucose-hemipermeable membrane, said first chamber cooperating with a first pressure sensor, which is turn is connected to an electronic system for transmitting information pertaining to the value of a measured pressure,

a second measuring chamber insulated from the surrounding medium by a second membrane permeable to glucose and non-permeable to molecules larger than glucose, this second chamber cooperating with a second pressure sensor, which in turn is connected to an electronic system for transmitting information pertaining to the value of a measured pressure, and

means associated with said first and second pressure sensors for providing through the difference between the measured pressures, an accurate estimation of the osmotic pressure due solely to glucose and, consequently, of the glucose level,

wherein the first and second membranes are each stiffened by a third perforated membrane of low elasticity, and each of the measuring chambers contains macromolecules, the concentration of which is selected according to the values of the osmotic pressures which are to be measured and to the optimal operational range of the first and second pressure sensors.

12. A device according to claim 11, characterized in that the means for providing an estimation of glucose levels includes means to take into account variations of such levels over time, by comparison with a data base established for a value or for known variations of the blood glucose level, this data base optionally being re-established at regular intervals of time of operation, depending on the nature of the selected hemipermeable membrane or on the patient.

13. A device according to claim 11, characterized in that the electronic system connected to the first and second pressure sensors is a LC-type resonant passive system, the resonance frequency of which varies as a function of the pressure which is measured, the value of this pressure being determined by a magnetically coupled variable oscillator.

14. A device according to claim 11, characterized in that the first and second pressure sensors are each made of photolithographically machined silicon.

15. An implantable device for estimating the glucose level by measuring the osmotic pressure due to glucose, characterized in that it comprises:

a first measuring chamber insulated from the surrounding medium by a first glucose-hemipermeable membrane, said first chamber cooperating with a first pressure sensor, which in turn is connected to an electronic system for transmitting information pertaining to the value of a measured pressure,

a second measuring chamber insulated from the surrounding medium by a second membrane permeable to glucose and non-permeable to molecules larger than glucose, this second chamber cooperating with a second pressure sensor, which in turn is connected to an electronic system for transmitting information pertaining to the value of a measured pressure, and

means associated with said first and second pressure sensors for providing through the difference between the measured pressures, an accurate estimation of the osmotic pressure due solely to glucose and, consequently, of the glucose level,

wherein the first and second membranes are each stiffened by a third perforated membrane of low elasticity, and each of the measuring chambers contains macromolecules, the concentration of which is selected according to the values of the osmotic pressures which are to be measured and to the optimal operational range of the first and second pressure sensors,

wherein the electronic system connected to the first and second pressure sensors is a LC-type resonant passive system, the resonance frequency of which varies as a function of the pressure which is measured, the value of this pressure being determined by a magnetically coupled variable oscillator, and each of the first and second pressure sensors is made of photolithographically machined silicon.