Method of preventing contamination of a chromatography column
First Claim
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1. A method of preventing contamination of a chromatography separation column containing stationary phase chromatographic material, by particulate or dissolved contaminants in a sample stream, comprising:
- retaining particulate and dissolved contaminants in a protective pad by passing the sample stream through the protective pad before the sample stream contacts the separation column, wherein said protective pad comprises a fabric or membrane sorptive chromatographic material.
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Abstract
Liquid chromatography separation columns can be protected from contamination with particulate and dissolved contaminants by the use of a thin protective pad which removes contaminants from a sample stream prior to separation of the sample on the separation column. The protective pad may be in the form of a guard disk positioned inline or directly contacting the separation column.
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Citations
22 Claims
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1. A method of preventing contamination of a chromatography separation column containing stationary phase chromatographic material, by particulate or dissolved contaminants in a sample stream, comprising:
retaining particulate and dissolved contaminants in a protective pad by passing the sample stream through the protective pad before the sample stream contacts the separation column, wherein said protective pad comprises a fabric or membrane sorptive chromatographic material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
Specification