Apparatus for preventing cross-contamination of multi-well test plates

• US 5,342,581 A
• Filed: 04/19/1993
• Issued: 08/30/1994
• Est. Priority Date: 04/19/1993
• Status: Expired due to Term

• Current Assignee: ASHOK R. SANADI AND CLYDE SANADI PTRS, Ashok R. Sandai, Clyde Sandai, Sanadi Biotech Group, Inc.
• Original Assignee: Sanadi Biotech Group, Inc.
• Inventors: Sanadi, Ashok R.
• Primary Examiner(s): Housel, James C.
• Assistant Examiner(s): Pyon, Harold Y.
• Application Number:
  US08/049,171
• Time in Patent Office: 498 Days
• Field of Search: 422/101, 422/102, 436/177, 436/178, 435/299, 435/300, 435/301, 435/311
• US Class Current: 422/552
• CPC Class Codes: B01L 3/5025 for parallel transport of multiple samples
• CPC Class Codes: B01L 3/50255 Multi-well filtration
• CPC Class Codes: B01L 3/5085 for multiple samples, e.g. microtitration plates
• CPC Class Codes: B01L 3/50853 with covers or lids
• CPC Class Codes: Y10T 436/25375 Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
• CPC Class Codes: Y10T 436/255 including use of a solid sorbent, semipermeable membrane, or liquid extraction

Abstract

A multi-well plate which prevents cross-contamination of specimens through the use of a resilient gasket which covers a majority of the top of the plate and is compressed by a lid. It thus provides a sealing assembly for arrays of containers of any size or shape. A multi-well plate of modular construction is also disclosed in which resilient gaskets prevent cross-contamination of samples. The gaskets may be unitary sheets with or without an array of openings corresponding to the well openings or may consist of discrete single-lell gaskets. A multi-well plate in which the wells have conical ends is also provided.

Claims

1. An assembly for simultaneously confining multiple samples in separate chambers, comprising:

a plate defining a plurality of containment wells, each well having an opening at a principal surface of said plate;

a resilient gasket disposed on and extending over the majority of said principal surface of said plate and closing said openings of said wells; and

a lid disposed on said resilient gasket having means for compressing said resilient gasket on said principal surface of said plate to hermetically seal said wells and to prevent said samples from flowing from one well to another between said lid and said principal surface of said plate.

2. The invention recited in claim 1, wherein said plate is a tray containing a plurality of tubes, each of said tubes defining one of said wells.

3. The invention recited in claim 1, further comprising a clamp which clamps said plate, resilient gasket, and lid together.