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Closed porous chambers for implanting tissue in a host

  • US 5,344,454 A
  • Filed: 04/01/1992
  • Issued: 09/06/1994
  • Est. Priority Date: 07/24/1991
  • Status: Expired due to Term
First Claim
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1. A chamber for implanting in host tissue comprisinga first housing member having an interior region,a first and second wall element, each having a peripheral edge, carried within the interior region of the first housing member,a sealing element having a body peripherally surrounding an open area, the sealing element being located within the interior region between the first and second wall elements with the sealing element body sandwiched between the peripheral edges of the first and second wall elements and the first and second wall elements jointly overlying the open area of the sealing member to form a chamber for holding implanted cells,a second housing member that nests within the interior region of the first housing member and bears against the peripheral edges of the wall elements and the sealing element body to created a sealed region that closes the chamber, andboth the first and second wall elements together with the sealed region being sufficiently impermeable to isolate the implanted cells within the chamber from the immune response of the host tissue, at least one of the first and second wall elements being sufficiently permeable to nutrients for transferring the nutrients from host tissue through the at least one element to the implanted cells within the chamber.

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