Closed porous chambers for implanting tissue in a host
First Claim
1. A chamber for implanting in host tissue comprisinga first housing member having an interior region,a first and second wall element, each having a peripheral edge, carried within the interior region of the first housing member,a sealing element having a body peripherally surrounding an open area, the sealing element being located within the interior region between the first and second wall elements with the sealing element body sandwiched between the peripheral edges of the first and second wall elements and the first and second wall elements jointly overlying the open area of the sealing member to form a chamber for holding implanted cells,a second housing member that nests within the interior region of the first housing member and bears against the peripheral edges of the wall elements and the sealing element body to created a sealed region that closes the chamber, andboth the first and second wall elements together with the sealed region being sufficiently impermeable to isolate the implanted cells within the chamber from the immune response of the host tissue, at least one of the first and second wall elements being sufficiently permeable to nutrients for transferring the nutrients from host tissue through the at least one element to the implanted cells within the chamber.
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Accused Products
Abstract
Improved Implant assemblies and methodologies provide immuno-protection for implanted allografts, xenografts, and isografts. The assemblies and methodologies establish an improved chamber for holding the implanted cells. The chambers include first and second wall elements and an intermediate sealing element. The first and second wall elements overlie an open area in the sealing member to form a chamber for holding cells for implantation. A sealed region is created between the wall elements and the sealing element body to close the chamber. In one arrangement, the sealed region is created by means of a sonic weld made while the implanted cells are present in the chamber. In another arrangement, the sealed region is created by means of applying an external force to compress the peripheral edges of the wall elements and the sealing element together while the implanted cells are present in the chamber.
1705 Citations
2 Claims
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1. A chamber for implanting in host tissue comprising
a first housing member having an interior region, a first and second wall element, each having a peripheral edge, carried within the interior region of the first housing member, a sealing element having a body peripherally surrounding an open area, the sealing element being located within the interior region between the first and second wall elements with the sealing element body sandwiched between the peripheral edges of the first and second wall elements and the first and second wall elements jointly overlying the open area of the sealing member to form a chamber for holding implanted cells, a second housing member that nests within the interior region of the first housing member and bears against the peripheral edges of the wall elements and the sealing element body to created a sealed region that closes the chamber, and both the first and second wall elements together with the sealed region being sufficiently impermeable to isolate the implanted cells within the chamber from the immune response of the host tissue, at least one of the first and second wall elements being sufficiently permeable to nutrients for transferring the nutrients from host tissue through the at least one element to the implanted cells within the chamber.
Specification