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Method for the long term reduction of body fat stores, insulin resistance, hyperinsulinemia and hyperglycemia in vertebrates

  • US 5,344,832 A
  • Filed: 06/24/1991
  • Issued: 09/06/1994
  • Est. Priority Date: 01/10/1990
  • Status: Expired due to Term
First Claim
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1. A method for modifying and regulating at least one of the lipid and glucose metabolism in a vertebrate animal or human subject in need of such treatment comprising:

  • administering a dopamine agonist to said subject on a times daily basis at a first predetermined time of day in a first dosage amount sufficient to reduce the hormonal prolactin level in the blood of said subject; and

    additionallyadministering a prolactin stimulator to said subject on a time daily basis at a second predetermined time of day in a second dosage amount sufficient to increase hormonal prolactin level in the blood of said subject;

    continuing said administrations for periods of time sufficient to modify and reset on a long-term basis the subject'"'"'s daily prolactin cycle to cause it to mimic the low level and peak of the daily prolactin cycle of a lean healthy member of the same species, thereby achieving in said subject at least one of the following modifications in lipid and glucose metabolism;

    decrease in insulin resistance, reduction in fat stores, suppression of hyperinsulinemia and reduction of hyperglycemia.

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