Temperature-controlled, micromachined arrays for chemical sensor fabrication and operation

• US 5,345,213 A
• Filed: 10/26/1992
• Issued: 09/06/1994
• Est. Priority Date: 10/26/1992
• Status: Expired due to Term

• Current Assignee: The United States of America As Represented By The Secretary of Agriculture
• Original Assignee: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
• Inventors: Gaitan, Michael, Cavicchi, Richard E., Suehle, John S., Semancik, Stephen
• Primary Examiner(s): Lateef, Marvin M.
• Application Number:
  US07/965,949
• Time in Patent Office: 680 Days
• Field of Search: 338/34, 338/35, 338/307, 338/25, 257/253, 257/252, 73/31.05, 73/31.06, 422/98, 422/90, 436/149, 436/113, 436/150, 436/151, 437/918, 437/248, 437/60
• US Class Current: 338/34
• CPC Class Codes: B01L 2300/1827 using resistive heater
• CPC Class Codes: B01L 2300/1883 using thermal insulation
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: B01L 7/54 using spatial temperature gradients
• CPC Class Codes: G01N 2035/00237 Handling microquantities of analyte, e.g. microvalves, capillary networks
• CPC Class Codes: G01N 27/18 caused by changes in the thermal conductivity of a surrounding material to be tested G01N27/20 takes precedence

Abstract

Planar forms of chemically-sensitive materials have been combined, under temperature control, with the pixels of a specially-designed micro-hotplate array to produce a miniature device capable of analyzing chemical mixtures. The device uses integrated multiple elements having different adsorption properties and temperatures to collectively achieve chemical selectivity in sensing. The method of making and using selectively in sensing. The device of the present invention is manufactured by standard CMOS foundry techniques which allow the production of a range of devices that have improved sensing performance.

Claims

1. A temperature-controlled sensor element which comprises:

a support substrate;

a microbridge structure formed on said support substrate;

a heating element formed on said microbridge structure so as to be thermally isolated from said support substrate;

a conductive heat distribution plate formed above said heating element for evenly distributing heat from said heating element and;

a layer of chemical active material formed above said conductive heat distribution plate.

2. A temperature-controlled sensor element according to claim 1, further including means to measure properties of said layer of chemical active material.

3. A temperature-controlled sensor element according to claim 2, wherein said means to measure properties of said layer of chemical active material comprises a plurality of contact pads beneath and in contact with said layer of chemical active material.

4. A temperature-controlled sensor element according to claim 1, wherein said conductive heat distribution plate includes four leads for sensing temperature.

5. A temperature-controlled sensor element according to claim 1, wherein a central portion of the microbridge structure is suspended over an etch pit which is formed in said substrate support.

6. A temperature-controlled sensor element according to claim 5, wherein said etch pit is formed with a closed bottom.

7. A temperature-controlled sensor element according to claim 1, wherein said chemical active material is adsorbent.

8. A temperature-controlled sensor element according to claim 1, wherein said chemical active material is catalytic.

9. A temperature-controlled sensor element according to claim 1, wherein said chemical active material is biologically active.

10. A temperature-controlled sensor element according to claim 1, wherein said conductive heat distribution plate is electrically conductive.

12. A temperature-controlled chemical sensor according to claim 10, wherein said chemical active material of each of said sensors is of the same material.

14. A temperature-controlled chemical sensor according to claim 10, wherein said chemical active material of each of said sensors is of a different chemical active material.

15. A temperature-controlled chemical sensor according to claim 10, wherein each of said heat distribution plates includes four leads for sensing temperature.

16. A temperature-controlled chemical sensor according to claim 10, wherein each of said sensor elements includes an etch pit beneath a central portion of its microbridge structure.

17. A temperature-controlled chemical sensor according to claim 15, wherein each of said etch pits includes a closed bottom.

18. A temperature-controlled chemical sensor according to claim 10, wherein said conductive heat distribution plate is electrically conductive.

20. A method of making a temperature-controlled sensor element according to claim 17, further comprising forming a plurality of contact pads beneath and in contact with said layer of chemical active material.

21. A method of making a temperature-controlled sensor element according to claim 17, which comprises forming a plurality of similar sensor elements on said substrate support.

23. A method of making a temperature-controlled sensor element according to claim 17, further comprising forming said conductive heat distribution plate from an electrically conductive material.

25. A method of detecting components of a fluid mixture according to claim 21, further comprising forming said conductive heat distribution plate from an electrically conductive material.

26. A method of detecting components of a fluid mixture according to claim 21, wherein said selectively heating comprises subjecting selective micro-hotplates to temperature variations.

27. A method of detecting components of a fluid mixture according to claim 21, further comprising regenerating the chemical active material after exposure by selectively heating said plurality of micro-hotplates above a regeneration temperature.

28. A method of detecting components of a fluid mixture according to claim 21, further comprising providing a protective layer over said chemical active material and selectively heating said plurality of micro-hotplates to burn off said protective layer and expose said chemical active material to said fluid mixture.

11. A temperature-controlled chemical sensor which comprises:

an array of sensor elements positioned on a substrate support, wherein each of said sensor elements comprises;

a microbridge structure formed on said support substrate;

a heating element formed on said microbridge structure so as to be thermally isolated from said support substrate;

a conductive heat distribution plate formed above said heating element for evenly distributing heat from said heating element and;

a layer of chemical active material formed above said conductive heat distribution plate.

13. A temperature-controlled chemical sensor according to claim 11, wherein said chemical active material of each of said sensors is tuned to be responsive differently to a chemical species.

19. A method of making a temperature-controlled sensor element which comprises:

providing a support substrate having a first layer of an insulating material;

forming a microbridge structure on said support structure;

forming a heating element on said microbridge structure;

forming a second layer of insulating material on said heating element;

forming a conductive heat distribution plate on said second layer of insulating material;

forming a third layer of insulating material on said conductive heat distribution plate; and

forming a layer of a chemical active material on said third layer of insulating material.

22. A method of making a temperature-controlled sensor element according to claim 19, wherein each of said plurality of sensor elements is made to respond differently to a chemical species.

24. A method of detecting components of a fluid mixture which comprises:

providing a substrate having a plurality of micro-hotplates, wherein each of said plurality of micro-hotplates is provided with a conductive heat distribution plate and can be individually temperature controlled;

providing a film of a chemical active material on each of said plurality of micro-hotplates;

selectively heating said plurality of micro-hotplates while exposing said chemical active material to a fluid mixture; and

measuring response of the chemical active material to said fluid mixture and determining therefrom the composition of said fluid mixture.