Method and system for monitoring of blood constituents in vivo

• US 5,345,932 A
• Filed: 01/15/1993
• Issued: 09/13/1994
• Est. Priority Date: 02/09/1990
• Status: Expired due to Fees

• Current Assignee: Terumo Cardiovascular Systems Corporation (Terumo Corporation)
• Original Assignee: 3M Company
• Inventors: Yafuso, Masao, Harker, Laurence A.
• Primary Examiner(s): Yasko, John D.
• Assistant Examiner(s): Rafa, Michael
• Application Number:
  US08/005,765
• Time in Patent Office: 606 Days
• Field of Search: 604/4, 604/5, 604/181, 604/265, 604/49, 128/632-634, 128/637, 128/666, 128/670, 128/760, 128/768, 128/772, 128/692, 128/833
• US Class Current: 600/368
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/6852 Catheters

Abstract

A method for determining the concentration of a constituent of blood employing a sensor in or near a catheter in a blood vessel for producing a signal related to the concentration of the constituent of blood is disclosed. The improvement comprises obtaining the signal while at least one of the following is present in the blood vessel: (1) an added vasodilator component and/or vasodilation promotor in an amount effective to reduce the vasoconstriction caused by the presence of the catheter in the blood vessel and (2) an added platelet/white cell inhibitor component and/or a platelet/white cell deactivation promotor in an amount effective to reduce the platelet and/or white cell activation caused by the presence of the catheter in the blood vessel.

Claims

1. A system for in vivo measurement of a constituent of a patient'"'"'s blood comprising:

a hollow catheter having an interior space and a distal end portion for being placed in a blood vessel of a patient, said distal end portion having an opening to allow blood to enter and exit said interior space of said catheter;

a sensor for sensing the concentration of a constituent of the patient'"'"'s blood and providing a signal in response thereto, said sensor being located in or near said interior space of said catheter;

introduction means for introducing at least one of the following into said blood vessel;

(1) at least one of a vasodilator component and a vasodilation promotor in an amount effective to reduce the vasoconstriction caused by the presence of said catheter in said blood vessel, thereby providing a more accurate determination of the concentration of the blood constituents, and (2) at least one of a platelet/white cell inhibitor component and a platelet/white cell deactivation promotor in an amount effective to reduce at least one of the platelet activation caused by the presence of said catheter in said blood vessel and the white cell activation caused by the presence of said catheter in said blood vessel, thereby providing a more accurate determination of the concentration of the blood constituent; and

a quantity of at least one of said vasodilator component, said vasodilation promotor, said platelet/white cell inhibitor component and said platelet/white cell deactivation promotor associated with said introduction means.

2. The system of claim 1 wherein said sensor is located in said interior space of said catheter in said blood vessel.

3. The system of claim 1 which further comprises elongated transmission means for transmitting said signal from said sensor proximally.

4. The system of claim 2 wherein said sensor and said transmission means are received in said interior space of said catheter in said blood vessel.

5. The system of claim 2 wherein said transmission means extends distally of said catheter through said interior space of said catheter.

6. The system of claim 1 wherein said introduction means includes said catheter.

7. The system of claim 1 wherein said introduction means includes an infusion pump.

8. The system of claim 1 wherein said vasodilator component is also said platelet/white cell inhibitor component.

9. The system of claim 1 wherein said added vasodilator component is selected from the group consisting of prostaglandin E₁, analogs of prostaglandin E1, prostaglandin E₂ analogs of prostaglandin E₂, prostacyclin I₂, analogs of prostacyclin I₂ and mixtures thereof.

10. The system of claim 1 wherein said vasodilator component is selected from the group consisting of prostaglandin E₁,analogs of prostaglandin E1 and mixtures thereof.

11. The system of claim 1 wherein said vasodilation promotor is also said platelet/white cell deactivation promotor.

12. The system of claim 1 wherein said vasodilation promotor is selected from the group consisting of defibrotide, analogs of defibrotide and mixtures thereof.

13. The system of claim 1 wherein said sensor includes an optical indicator.

14. The system of claim 1 wherein said sensor includes a fluorescence indicator.

15. The system of claim 1 wherein said constituent of blood is selected from oxygen, carbon dioxide, H⁺, glucose and other electrolytes.

16. The system of claim 1 wherein said sensor is a component of a probe which includes at least one other sensor for producing a signal related to the concentration of another constituent of blood.

17. The system of claim 1 wherein said elongated transmission means comprises an optical fiber and said sensor includes an optical indicator.

18. The system of claim 17 wherein said optical indicator is a fluorescence indicator.

19. A system for the in vivo measurement of a constituent of a patient'"'"'s blood comprising:

a sensor for sensing the concentration of a constituent of interest of a patient'"'"'s blood and providing a signal in response thereto, said sensor being located in a blood vessel of said patient;

introduction means for introducing at least one of the following into said blood vessel;

(1) at least one of a vasodilator component and a vasodilation promotor in an amount effective to reduce the vasoconstriction caused by the presence of said sensor in said blood vessel, thereby providing a more accurate determination of the concentration of the blood constituent, and (2) at least one of a platelet/white cell inhibitor component and a platelet/white cell deactivation promotor in an amount effective to reduce at least one of;

(A) the platelet activation caused by the presence of said sensor in said blood vessel, and (B) the white cell activation caused by the presence of said sensor in said blood vessel, thereby providing a more accurate determination of the concentration of the blood constituent; and

a quantity of at least one of said vasodilator component, said vasodilation promotor, said platelet/white cell inhibitor component and said platelet/white cell deactivation promotor associated with said introduction means.

20. The system of claim 19 which further comprises elongated transmission means for transmitting said signal from said sensor proximally.

21. The system of claim 19 wherein said introduction means includes an infusion pump.

22. The system of claim 19 wherein said vasodilator component is also said platelet/white cell inhibitor component.

23. The system of claim 19 wherein said added vasodilator component is selected from the group consisting of prostaglandin E₁, analogs of prostaglandin E1, prostaglandin E₂ analogs of prostaglandin E₂, prostacyclin I₂, analogs of prostacyclin I₂ and mixtures thereof.

24. The system of claim 19 wherein said vasodilator component is selected from the group consisting of prostaglandin E₁,analogs of prostaglandin E₁ and mixtures thereof.

25. The system of claim 19 wherein said vasodilation promotor is also said platelet/white cell deactivation promotor.

26. The system of claim 19 wherein said vasodilation promotor is selected from the group consisting of defibrotide, analogs of defibrotide and mixtures thereof.

27. The system of claim 19 wherein said sensor includes an optical indicator.

28. The system of claim 19 wherein said sensor includes a fluorescence indicator.

29. The system of claim 19 wherein said constituent of blood is selected from oxygen, carbon dioxide, H⁺, glucose and other electrolytes.

30. The system of claim 19 wherein said sensor is a component of a probe which includes at least one other sensor for producing a signal related to the concentration of another constituent of blood.

31. The system of claim 19 wherein said elongated transmission means comprises an optical fiber and said sensor includes an optical indicator.

32. The system of claim 31 wherein said optical indicator is a fluorescence indicator.