Implantable medical device with a protected medication layer

• US 5,345,933 A
• Filed: 09/14/1992
• Issued: 09/13/1994
• Est. Priority Date: 09/25/1991
• Status: Expired due to Term

• Current Assignee: Pacesetter AB
• Original Assignee: Siemens AG
• Inventors: Peterson, Lars-Olof, Stroetmann, Brigitte, Lindegren, Ulf
• Primary Examiner(s): KRUTER, JEROME
• Application Number:
  US07/944,265
• Time in Patent Office: 729 Days
• Field of Search: 128/639, 128/640, 128/641, 128/644, 128/785, 128/785, 128/786, 604/20
• US Class Current: 600/377
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 2300/608 having two or more layers
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence

Abstract

An implantable medical device has surfaces that are in communication with the tissue of the patient after an implantation. At least one part of these surfaces is provided with at least one layer composed of a medication. In order to simply and reliably control the administration of a desired quantity of the medication, the medication layer is covered by at least one layer composed of an ion exchanger material.

Claims

1. An implantable medical device having ion exchange properties, said device having surfaces which are in communication with the tissue of a patient after implantation of said device, at least a part of these surfaces being covered by a layer composed of a medication, and said layer composed of a medication being covered by at least one layer composed of an ion exchanger material.

2. An implantable medical device as claimed in claim 1 wherein said device is a heart simulation device or a part thereof.

3. An implantable medical device as claimed in claim 1 wherein said device is a heart stimulation electrode.

4. An implantable medical device as claimed in claim 3 wherein said heart stimulation electrode is a heart pacemaker electrode having at least one stimulation surface, said stimulation surface being covered by said at least one medication layer and said at least ion exchanger material layer.

5. An implantable medical device as claimed in claim 4 wherein said stimulation surface consist of a microporous material.

6. An implantable medical device as claimed in claim 4 wherein said stimulation surface of said heart pacemaker electrode has a maximum area of 4 mm².

7. An implantable medical device as claimed in claim 1 wherein said device is an infusion pump.

8. An implantable medical device as claimed in claim 1 comprising a plurality of said layers of medication and a plurality of said layers of ion exchanger material, disposed in alternation above one another.

9. An implantable medical device as claimed in claim 1 wherein said layer of medication has a thickness in a range between 0.5 μ

m and 4 μ

m.

10. An implantable medical device as claimed in claim 9 wherein said layer of medication has a thickness of approximately 2 μ

m.

11. An implantable medical device as claimed in claim 1 wherein said layer of ion exchanger material has a thickness in a range between 0.5 μ

m and 4 μ

m.

12. An implantable medical device as claimed in claim 1 wherein said layer of ion exchanger material has a thickness of approximately 2 μ

m.

13. An implantable medical device as claimed in claim 1 wherein each of said layer of medication and said layer of ion exchanger material have respective thicknesses which are independently variable.