Apparatus and method for performing diagnostics and intravascular therapies

• US 5,346,508 A
• Filed: 04/29/1993
• Issued: 09/13/1994
• Est. Priority Date: 04/29/1993
• Status: Expired due to Term

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Inventors: Hastings, Roger
• Primary Examiner(s): Sykes, Angela D.
• Application Number:
  US08/055,702
• Time in Patent Office: 502 Days
• Field of Search: 128/691-692, 128/713, 607/89, 607/99, 607/100, 606/7, 606/27-31, 606/41-42, 606/192, 606/194, 604/96
• US Class Current: 607/99
• CPC Class Codes: A61B 5/028 by thermo-dilution
• CPC Class Codes: A61B 5/6851 Guide wires
• CPC Class Codes: A61M 2025/0002 with a pressure sensor at the distal end
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/36 related to heating or cooling
• CPC Class Codes: A61M 29/02 Dilators made of swellable material balloon catheters for angioplasty A61M25/104
• CPC Class Codes: G01F 1/68 by using thermal effects
• CPC Class Codes: G01F 1/69 of resistive type
• CPC Class Codes: G01F 1/698 Feedback or rebalancing circuits, e.g. self heated constant temperature flowmeters
• CPC Class Codes: G01P 5/12 using variation of resistance of a heated conductor

Abstract

An apparatus and method for performing diagnostics and intravascular therapies. A guidewire anemometer can be used to measure the velocity of fluid flowing through the vasculature. An in-line anemometer can be used to measure the volumetric flow rate of fluid transported out of a patient'"'"'s body. A heated balloon catheter can be used to deliver heat therapy no a vessel wall in a patient'"'"'s vasculature.

Claims

1. An apparatus for performing intravascular therapy comprising:

a catheter having a shaft and a balloon attached to a distal portion of the shaft wherein the interior of the balloon communicates with an inflation lumen in the shaft used to deliver inflation fluid to the interior of the balloon;

a controlled signal source for generating a variable driving signal;

a heating element located in the interior of the balloon, the heating element communicating with the signal source which receives the variable driving signal and heat the inflation fluid within the balloon;

a current meter communicating with the heating element which measures the current flowing through the heating element;

a voltage meter communicating with the heating element to measure the voltage across the heating element;

a divider circuit communicating with the current meter and the voltage meter which generates a measured signal;

a subtractor circuit communicating with the measure signal which compares the measured signal with a desired signal and generates an output signal representative of the comparison; and

a feedback circuit communicating with the subtractor circuit to receive the output of the subtractor circuit and generate an output signal having an exponential relation to the output of the subtractor circuit, the output of the feedback circuit communicating with the signal source to vary the driving signal delivered to the heating element;

wherein the shaft of the catheter includes an inner tubular member extending through the interior of the balloon, an outer tubular member concentrically located around the exterior of the inner tubular member wherein the inflation lumen is formed between the outer and inner tubular members, wherein the heating element is supported on the inner tubular member.

2. An apparatus according to claim 1 wherein the heating element comprises a coil bifilarly wound around the inner tubular member.

3. An apparatus according to claim 2 wherein the coil is formed from a silver wire.

4. An intravascular anemometer comprising:

a guidewire having a proximal and distal end; and

a heating element located near the distal end of the guidewire wherein the temperature of the heating element is directly proportional to the resistance of said heating element and said heating element is raised to a selected target temperature and the power needed to maintain the temperature of the heating element at said selected target temperature when the guidewire is positioned in the vasculature is measured and converted into a velocity measurement and wherein the resistance of said heating element is measured and used to modulate the power provided to said heating element to maintain said heating element at said selected target temperature during said velocity measurement.

5. An anemometer according to claim 4 wherein the guidewire includes:

a guidewire core having a proximal and distal end; and

a tubular member positioned over a distal portion of the guidewire core, the tubular member connected to the guidewire core at a position distal from the proximal end of the guidewire core, wherein the heating element is located on the tubular member.

6. An anemometer according to claim 5 wherein the heating element comprises a coil bifilarly wound around an exterior portion of the tubular member.

7. An in-line anemometer comprising:

an inner tubular member defining an inner lumen;

a heating element positioned on the exterior of the inner member;

an intermediate member formed by two side tubes, each tube placed concentrically over an end portion of the inner tubular member wherein the tubes are separated from one another by the heating element; and

an outer tubular member concentrically disposed over the heating element and a portion of the side tubes, wherein the temperature of the heating element is raised to a select temperature and the power needed to maintain the temperature of the heating element at the select temperature when fluid is flowing through the inner lumen is measured and the flow rate of the fluid through the tube is derived from said measurement.

8. An in-line anemometer according to claim 7 wherein the inner member is formed of polyimide.

9. An in-line anemometer according to claim 7 wherein the intermediate member and outer member are formed of a low friction material.

10. An in-line anemometer according to claim 7 wherein the heating element is a coil wound around the exterior of the inner member.

11. An in-line anemometer comprising:

an inner member having an inner lumen, and said inner lumen having an exterior surface;

a heating element being placed on said exterior surface of the inner member;

an intermediate member formed by two side tubes, each tube placed concentrically over a portion of the inner member, the two side tubes being separated by the heating element;

an outer member concentrically disposed over the combination of the inner member, heating element and intermediate member;

a controlled signal source means for generating a variable driving signal wherein the signal source communicates with the heating element and supplies the variable driving signal to the heating element;

a current meter communicating with the heating element which measures the current flowing through the heating element;

a voltage meter communicating with the heating element to measure the voltage across the heating element;

a divider circuit communicating with the current meter and the voltage meter which generates a measured signal; and

a subtractor communicating with the measured signal which compares the measured signal with a desired signal and generates an output signal representative of the comparison, the output of the subtractor communicating with the signal source to vary the driving current delivered to the heating element.

12. An anemometer for measuring blood flow in a vascular comprising:

an elongate body structure for introduction into said vasculature, and having a proximal end and having a distal end;

a heating element located proximate to said distal end of said body structure and exposed to blood flow in said vasculature;

said heating element exhibiting a resistance proportional to the temperature of said heating element, and said heating element coupled to a modulated current source;

means for establishing a target temperature for said heating element;

a linear feedback control system for modulating said modulated current source when said heating element is near a selected target temperature range defined with respect to said target temperature;

a non-linear feedback control system for modulating said modulated current source when said heating element is outside of a selected target temperature range defined with respect to said target temperature;

whereby, said temperature of said heating element is maintained at said target temperature for determination of blood velocity at the location of said heating element.

13. The apparatus of claim 12 wherein said elongate body structure comprises a guidewire having an exterior surface, with said heating element located on said exterior surface.

14. The apparatus of claim 12 wherein said elongate body structure comprises a catheter having an exterior surface and an interior lumen, with said heating element located on said exterior surface.

15. The apparatus of claim 12 wherein said elongate body structure comprises a catheter having an exterior surface and an interior lumen, with said heating element located on said interior lumen.