Nail lacquer for the treatment of onychomycosis
First Claim
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1. A nail lacquer (nail polish) for treatment of onychomycosis, comprising:
- a) a polymeric film forming agent,b) at least one antimycotically active substance,c) urea; and
d) a solvent which comprisesi) 50-70 wt. % of acetone; and
(ii) 30-50 wt. % of 90 volume % aqueous ethanol;
wherein in a first step, said polymeric film forming agent is dissolved in said acetone component of said solvent, and then in a second step, said antimycotically active substance and said urea are added to said polymeric film forming agent, in dissolved form in said aqueous ethanol; and
wherein following topical application and drying of said nail lacquer, the antimycotically active substance and said urea are liberated from the lacquer.
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Abstract
The invention relates to a nail lacquer for treating onychomycosis, comprised of a film-forming agent, an antimycotically active substance, and urea, wherewith the antimycotically active substance and the urea are liberated from the lacquer when the lacquer is applied. A preferred formulation comprises cellulose derivative(s) as film former(s), clotrimazole as the antimycotic (present in the amount of 5-30 wt. % based on the weight of the non-volatile components), urea (present in the amount of 15-60 wt. % based on the weight of the non-volatile components), and dibutyl phthalate as a plasticizer, in a solvent mixture comprised of acetone and ethanol.
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Citations
13 Claims
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1. A nail lacquer (nail polish) for treatment of onychomycosis, comprising:
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a) a polymeric film forming agent, b) at least one antimycotically active substance, c) urea; and d) a solvent which comprises i) 50-70 wt. % of acetone; and (ii) 30-50 wt. % of 90 volume % aqueous ethanol; wherein in a first step, said polymeric film forming agent is dissolved in said acetone component of said solvent, and then in a second step, said antimycotically active substance and said urea are added to said polymeric film forming agent, in dissolved form in said aqueous ethanol; and wherein following topical application and drying of said nail lacquer, the antimycotically active substance and said urea are liberated from the lacquer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification