Hydrogel

• US 5,346,935 A
• Filed: 11/02/1993
• Issued: 09/13/1994
• Est. Priority Date: 05/28/1991
• Status: Expired due to Fees

• Current Assignee: Takeda Chemical Industries, Ltd. (Takeda Pharmaceutical Company Limited)
• Original Assignee: Takeda Chemical Industries, Ltd. (Takeda Pharmaceutical Company Limited)
• Inventors: Suzuki, Yasuyuki, Shimizu, Hisayoshi
• Primary Examiner(s): REDDICK, MARIE L
• Application Number:
  US08/144,510
• Time in Patent Office: 315 Days
• Field of Search: 524/27, 524/29, 524/503, 524/552, 524/17, 524/18, 524/21, 524/24
• US Class Current: 524/18
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00

Abstract

The hydrogel of the invention contains polyvinyl alcohol (a hydrogel support), and a high water-absorbent resin and/or a hydrophilic high molecular compound, which are capable of containing a large amount of water. The rate of evaporation of water from this hydrogel is slow. The hydrogel retains water for a long time and releases an active ingredient gradually. The hydrogel containing a pharmacologically active substance is useful as a pharmaceutical preparation.

Claims

1. A hydrogel consisting essentially of water, protirelin, polyvinyl alcohol and at least one substance which can absorb 50 to 2000 times their weights of water, the substance which can absorb water being selected from the group consisting of water-absorbent resins, polyacrylate salt polymers, hyaluronic acid or a salt thereof and β

-1,3-glucan.

2. The hydrogel of claim 1 wherein the polyvinyl alcohol has an average degree of polymerization in the range of 1700 to 2500.

3. The hydrogel of claim 1 wherein the polyvinyl alcohol has a saponification degree of not less than 95 mole percent.

4. The hydrogel of claim 1 wherein the total content of the at least one substance which can absorb water is within the range of 0.1 to 10 weight % based on the weight of the hydrogel.

5. The hydrogel of claim 1 wherein the water-absorbent resin is at least one resin selected from the group consisting of a metal salt of hydrolyzed copolymer composed of vinyl acetate and alkyl (meth)acrylate, crosslinked vinyl alcohol-maleic anhydride copolymer, crosslinked vinyl alcohol-acrylic acid-maleic anhydride copolymer, crosslinked isobutylene-maleic acid copolymer, saponified polyacrylonitrile graft polymer and starch-acrylic acid graft polymer.

6. The hydrogel of claim 1 wherein the water-absorbent resin is a sodium salt of a hydrolyzed copolymer composed of vinyl acetate and methyl acrylate.

7. The hydrogel of claim 1 which contains sodium hyaluronate.

8. The hydrogel of claim 1 which contains β

-1,3-glucan.