Pheresis apparatus

• US 5,348,533 A
• Filed: 08/27/1992
• Issued: 09/20/1994
• Est. Priority Date: 08/27/1992
• Status: Expired due to Fees

• Current Assignee: Haemonetics Corporation
• Original Assignee: Haemonetics Corporation
• Inventors: York, Frederick J., Papillon, Jean
• Primary Examiner(s): Hafer, Robert A.
• Assistant Examiner(s): RIMELL, SAMUEL G
• Application Number:
  US07/936,569
• Time in Patent Office: 754 Days
• Field of Search: 604/4, 604/5, 604/6, 604/19, 604/27, 604/48, 494/1, 494/10, 494/11, 494/16, 494/43
• US Class Current: 604/6.07
• CPC Class Codes: A61M 1/3643 Priming, rinsing before or after use
• CPC Class Codes: A61M 1/3644 Mode of operation
• CPC Class Codes: A61M 1/3693 using separation based on different densities of components, e.g. centrifuging
• CPC Class Codes: A61M 1/3696 with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
• CPC Class Codes: A61M 2205/3393 by weighing the reservoir

Abstract

The length of time required to draw, centrifugally separate, harvest blood components and return blood components is reduced by providing a two-arm pheresis system in which blood is drawn from one arm, anticoagulated and pumped into an input reservoir then transferred into a centrifuge bowl for separation, while separated blood components are harvested and returned to the donor from an output reservoir via another arm.

Claims

1. Apparatus comprising:

a) a draw needle for drawing whole blood from a donor;

b) an input buffer in fluid communication with said draw needle via a first conduit;

c) a second conduit for fluidly coupling anticoagulant fluid to said first conduit for mixing with said drawn blood;

d) a separator for separating drawn blood into at least two fractional components, said separator having an input port and an output port;

e) a third conduit for fluidly coupling the input buffer to the input port;

f) a component container;

g) a fourth conduit for fluidly coupling the output port to said container;

h) an output buffer;

i) a fifth conduit in fluid communication with said output buffer and said fourth conduit;

j) a sixth conduit in fluid communication between said output buffer and said third conduit;

k) a return needle in fluid communication with one or more of said output buffer or said component container for transferring fluid therefrom to said donor; and

l) a seventh conduit for fluidly coupling said output buffer to a source of physiological solution.

2. The apparatus of claim 1 wherein the input buffer, output buffer and component container comprise plastic bags.

3. The apparatus of claim 1 wherein the separator comprises a centrifuge bowl.

4. The apparatus of claim 3 wherein the centrifuge bowl is comprised of a stationary input/output section coupled by a rotary seal to a rotating bowl section.

5. The apparatus of claim 1 including a pump for transferring said separated components and wherein one of the fractional components is plasma and wherein plasma is transferred from the output port to the component container.

6. The apparatus of claim 1 including a pump for transferring said separated components and wherein one of the fractional components is platelets and wherein platelets are transferred from the output port to the component container.

7. The apparatus of claim 1 wherein the physiological solution is saline.

8. The apparatus of claim 1 further including pump means for transferring anticoagulated whole blood into the input buffer.

9. The apparatus of claim 8 wherein anticoagulated whole blood in the input buffer is transferred by said pump means out of the input buffer to said input port at the same rate it is being transferred in.

10. The apparatus of claim 9 wherein fluid is transferred by said pump means from the output buffer to the donor at the same rate whole blood is being drawn from said donor.

11. Apparatus comprising:

a) a draw needle for drawing whole blood from a donor;

b) an input buffer in fluid communication with said draw needle via a first conduit;

c) a second conduit for fluidly coupling anticoagulant fluid to said first conduit for mixing with said drawn blood;

d) a separator for separating drawn blood into at least two fractional components, said separator having an input port and an output port;

e) a third conduit for fluidly coupling the input buffer to the input port;

f) a component container;

g) a fourth conduit for fluidly coupling the output port to said container;

h) an output buffer;

i) a fifth conduit in fluid communication with said output buffer and said fourth conduit;

j) a sixth conduit in fluid communication between said output buffer and said third conduit;

k) a return needle in fluid communication with one or more of said output buffer or said component container for transferring fluid therefrom to said donor via a seventh conduit;

l) a seventh conduit for fluidly coupling said output buffer to a source of physiological solution;

m) draw pump means coupled to said first conduit for transferring drawn blood from said draw needle to said input buffer;

n) A.C. pump means coupled to said second conduit for transferring anticoagulant from an anticoagulant source to mix with said drawn blood;

o) transfer pump means coupled to said third conduit for transferring in a first direction fluid from said input buffer to said input port and in a second direction fluid from said component container to said input port or to said output buffer; and

p) return pump means coupled to said seventh conduit for transferring fluid from one or more of said output buffer or said component container to said donor.

12. The apparatus of claim 11 wherein the input buffer, output buffer and component container comprise plastic bags.

13. The apparatus of claim 11 wherein the separator comprises a centrifuge bowl.

14. The apparatus of claim 13 wherein the centrifuge bowl is comprised of a stationary input/output section coupled by a rotary seal to a rotating bowl section.

15. The apparatus of claim 11 including a pump for transferring said separated components and wherein one of the fractional components is plasma and wherein plasma is transferred from the output port to the component container.

16. The apparatus of claim 11 including a pump for transferring said separated components and wherein one of the fractional components is platelets and wherein platelets are transferred from the output port to the component container.

17. The apparatus of claim 11 wherein the physiological solution is saline.

18. The apparatus of claim 11 further including pump means for transferring anticoagulated whole blood into the input buffer.

19. The apparatus of claim 18 wherein anticoagulated whole blood in the input buffer is transferred by said pump means out of the input buffer to said input port at the same rate it is being transferred in.

20. The apparatus of claim 19 wherein fluid is transferred by said pump means from the output buffer to the donor at the same rate whole blood is being drawn from said donor.

21. A method for separating whole blood collected from a donor via a draw needle into constituent components and returning some of the separated components via a return needle in a centrifugal separation system comprised of a centrifuge having a stator and a rotatable bowl with the stator having an input port fluidly coupled on one side to an input reservoir and on another side to the interior of the bowl and an output port fluidly coupled on one side to the interior of the bowl and on another side to an output reservoir and a component container;

comprising the steps of;

a) priming the system by transferring a volume of physiological solution from a solution bag into the output reservoir and transferring a volume of anticoagulant from an anticoagulant bag into the input reservoir and pumping some of the solution in the output reservoir to the return needle by a return pump;

b) drawing blood from the donor via the draw needle and mixing the blood with anticoagulant and transferring the anticoagulant drawn blood into the input reservoir by a draw pump;

c) transferring the physiological fluid from the output reservoir by the return pump into the donor via the return phlebotomy needle; and

d) transferring the anticoagulated whole blood from the input reservoir to the input port of the bowl by a transfer pump causing some blood component(s) to be separated in the bowl and to exit the bowl and enter a component container for harvesting while other separated component(s) are transferred to said output reservoir; and

e) transferring fluid from the output reservoir to the donor via the return phlebotomy needle.

22. The method of claim 21 wherein the input reservoir, output reservoir and component container are formed of disposable plastic bags.

23. The method of claim 21 wherein the transferring is performed by pumps.

24. The method of claim 21 wherein the pumps are peristaltic type pumps.

25. The method of claim 21 including a pump for transferring said separated components and wherein one of the fractional components is plasma and wherein plasma is transferred from the output port to the component container.

26. The method of claim 21 including a pump for transferring said separated components and wherein one of the fractional components is platelets and wherein platelets are transferred from the output port to the component container.

27. The method of claim 21 wherein the physiological solution is saline.

28. The method of claim 21 further including pump means for transferring anticoagulated whole blood into the input reservoir.

29. The method of claim 21 wherein anticoagulated whole blood in the input reservoir is transferred out of the input reservoir to said input port at the same rate it is being transferred in.

30. The method of claim 21 wherein fluid is transferred from the output reservoir to the donor at the same rate whole blood is being drawn from said donor.