Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow

• US 5,349,947 A
• Filed: 07/15/1993
• Issued: 09/27/1994
• Est. Priority Date: 07/15/1993
• Status: Expired due to Fees

• Current Assignee: Baines W. Douglas, Newhouse, Michael T.
• Original Assignee: Baines W. Douglas, Newhouse, Michael T.
• Inventors: Newhouse, Michael T., Baines, W. Douglas
• Primary Examiner(s): Asher, Kimberly L.
• Application Number:
  US08/092,085
• Time in Patent Office: 439 Days
• Field of Search: 128/203.15, 128/203.12, 128/203.21, 128/200.21, 128/200.22, 604/58-64, 604/77, 206/531-533, 206/538, 206/539
• US Class Current: 128/203.21
• CPC Class Codes: A61M 15/0015 located upstream of the dispenser, i.e. not traversed by the product
• CPC Class Codes: A61M 15/0018 with exhalation check valves
• CPC Class Codes: A61M 15/0028 using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• CPC Class Codes: A61M 15/0031 by bursting or breaking the package, i.e. without cutting or piercing
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: A61M 15/005 the dosages being arranged on a cylindrical surface
• CPC Class Codes: A61M 15/0086 Inhalation chambers
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/6081 Colour codes
• CPC Class Codes: B65D 83/06 for dispensing powdered or granular material B65D83/04 takes precedence

Abstract

A powder inhaler and process are provided for aerosolizing finely powdered or pulverized medication and a gas provided in a pillow or blister-type container of extremely thin elastic suitable plastic construction. The pillow is compressed between an anvil with a conical depression and a confronting conical piston. The conical depression has a small orifice at its apex, and the periphery of the pillow is restrained so that compression between the conical pillow and the conical depression produces explosive rupture of the pillow and exit of the gas and medication at a very high speed up to supersonic through said orifice. Medication particle clumps are very efficiently separated into separate particles, and the gas/medication exiting from the orifice are conveyed through a very small area linear or curved tube to a dispersal chamber or directly to a patient, movement through the tube producing a shearing action further enhancing separation of aggregated particles of powder medication.

Claims

1. A powder inhaler assembly for dispersing medication, said assembly not using a propellant, said assembly comprising a pillow containing a dose of powdered medication and gas, said pillow constructed of plastic means for explosively discharging the powdered medication and gas from inside said pillow comprising a housing having a dispersal chamber, means providing an exit from said chamber for transporting dispersed medication to a patient, a support in said housing, said support having a depression of predetermined shape and having a maximum transverse dimension of predetermined size, said depression having an outlet orifice which is small relative to said predetermined size, a piston positioned opposite to said depression and having a surface confronting said depression which at least in part conforms to said depression, means for moving said piston towards said depression to compress a medication pillow therein, means associated with said piston and said depression for providing peripheral support to a medication pillow, said pillow being completely restrained except for said orifice, the gas in said pillow compressing responsive to continued movement of said piston toward said depression and resulting in explosive rupturing of said pillow, said dose and gas exploding and deaggregating into said orifice and through said orifice, for inhalation by a patient, wherein said exit means includes a conduit means from said orifice to said dispersal chamber for transmission of aerosolized medication to a patient.

2. A powder inhaler assembly as set forth in claim 1 wherein said depression is at least in part conical, said conical depression having an apex, said outlet orifice being located at said apex.

3. A powder inhaler assembly as set forth in claim 2 wherein said peripheral restraint comprises a cylinder.

4. A powder inhaler assembly as set forth in claim 1 wherein said peripheral restraint comprises a cylinder.

5. A powder inhaler assembly as set forth in claim 1 wherein said peripheral support comprises conformation of one of said depression and said piston which is initially nonconforming to the other such that radially outward portions of said piston and said depression engage before radially inner portions, at least one of said piston and said depression subsequently deforming to conform to the shape of the other thereof.

6. A powder inhaler assembly as set forth in claim 5 wherein said depression is conical having an apex, said orifice being disposed at said apex.

7. A powder inhaler assembly as set forth in claim 6 wherein the radially outer portion of said depression has a predetermined angle, and a radially inner portion thereof has a steeper angle, said piston being constructed of deformable material, and a radially inner portion of said piston deforms to conform to said radially inner portion of said depression.

8. A powder inhaler assembly as set forth in claim 6 wherein said conical depression has a predetermined angle, said piston has a radially inner portion conforming to said conical depression and having the same predetermined angle, a radially outer portion of said piston having a different angle, said piston being deformable to conform to said conical depression.

9. A powder inhaler assembly as set forth in claim 8 wherein the radially outer portion of said piston is flat.

10. A powder inhaler assembly as set forth in claim 9 wherein said conduit means has a small cross section relative to said predetermined size to provide shearing forces enhancing deagregation of said powdered medication.

11. A powder inhaler assembly as set forth in claim 10 wherein said conduit means is curved.

12. A powder inhaler assembly as set forth in claim 10 wherein said conduit means comprises a spiral.

13. Apparatus for dispersing of medication, said apparatus not using a propellant, said apparatus comprising, a pillow containing powdered medication and a gas together in said pillow said pillow being of plastic construction;

said apparatus further comprising means for explosively discharging the powdered medication and gas from within said pillow comprising a base, a support on said base, said support having a depression of predetermined shape and having a maximum transverse dimension of predetermined size, said depression having an outlet orifice which is small relative to said predetermined size, a piston positioned opposite to said depression and having a surface confronting said depression which at least in part conforms to said depression, means for moving said piston towards said depression to compress said medication pillow positioned therein, means associated with said piston and depression for providing peripheral support to said medication pillow, said pillow being completely restrained except for said orifice, the gas in said pillow compressing responsive to continued movement of said piston toward said depression and resulting in explosive rupturing of said pillow, said dose of powdered medication and gas exploding and deaggregating into said orifice for inhalation by a patient.

14. Apparatus as set forth in claim 13 and further including a conduit of small cross section relative to said predetermined size leading from said orifice for enhancing of deaggregation by shearing action.

15. Apparatus as set forth in claim 14 wherein said peripheral restraint comprises a cylinder.

16. Apparatus as set forth in claim 13 wherein said peripheral restraint comprises a cylinder.

17. Apparatus as set forth in claim 13 wherein said peripheral support comprises conformation of one of said depression and said piston which is initially nonconforming to the other such that radially outward portions of said piston and said depression engage before radially inner portions, at least one of said piston and said depression subsequently deforming to conform to the shape of the other thereof.

18. Apparatus as set forth in claim 17 wherein said depression is conical having an apex, said orifice being disposed at said apex.

19. Apparatus as set forth in claim 18 wherein the radially outer portion of said depression has a predetermined angle, and a radially inner portion thereof has a steeper angle, said piston being constructed of deformable material, and a radially inner portion of said piston deforms to conform to said radially inner portion of said depression.

20. Apparatus as set forth in claim 18 wherein said conical depression has a predetermined angle, said piston has a radially inner portion conforming to said conical depression and having the same predetermined angle, a radially outer portion of said piston having a different angle, said piston being deformable to conform to said conical depression.

21. Apparatus as set forth in claim 20 wherein the radially outer portion of said piston is flat.

22. A process for propellant free dispersing of powder medication, said process comprising the steps of providing a plastic pillow containing powder medication and a gas, completely surrounding said pillow except for a very small area relative to the size of said pillow, explosively rupturing said pillow at said small area by compressing said pillow and the gas within said pillow while so surrounded and thereby deaggregating said powder medication, and delivering said deaggregated powder medication to a patient for inhalation.

23. The process as set forth in claim 22 and further including the step of guiding gas and medication from said very small area along a path of small cross section to produce a shearing action further separating clumps of medication.

24. The process as set forth in claim 23 wherein the step of guiding gas and medication along a path of small cross section comprises moving said powder medication and gas along a curved path.