Photoplethysmographics using phase-division multiplexing

• US 5,349,952 A
• Filed: 03/05/1991
• Issued: 09/27/1994
• Est. Priority Date: 03/05/1991
• Status: Expired due to Term

• Current Assignee: Sensormedics Corporation (Becton, Dickinson & Co)
• Original Assignee: Sensormedics Corporation (Becton, Dickinson & Co)
• Inventors: Smith, Robert, McCarthy, Rex
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): NASSER, ROBERT L
• Application Number:
  US07/665,594
• Time in Patent Office: 1,302 Days
• Field of Search: 128/633, 128/664-665, 356/39-41, 250/339, 364/413.03
• US Class Current: 600/473
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/417 the bone marrow
• CPC Class Codes: G01N 21/3151 using two sources of radiation of different wavelengths G01N21/33 - G01N21/39 take precedence

Abstract

First and second carrier signals, distinguishable by phase, are respectively applied to infrared and red energy emitters. A detector receives the sum of the energy after modulation at the infrared and red wavelengths. The signal received by the detector is then demultiplexed into its original first and second components, thereby allowing determining of both the infrared and red modulation components. The first and second carrier signals may comprise time-varying periodic signals with identical frequency and frequency spectra, such as a pair of sine waves which are indistinguishable except by phase and amplitude. A 90° phase difference is preferred, but any phase other than 0 or an integer multiple of 180° is workable. A carrier frequency which avoids excessive interference from ambient light is preferred.

Claims

1. An instrument for evaluating the concentration of a constituent in an object by measuring the transmission of light of two wavelengths therethrough, comprising:

(a) first and second light emitter means for emitting light at respective, first and second different wavelengths;

(b) modulator/driver means for driving the light emitter means simultaneously with respect first and second carriers which vary as a function of time, the carriers being continuous time-varying signals of the same carrier frequency and having a phase difference other than 0°

degrees and other than an integer multiple of 180°

degrees, wherein said first and second light emitter means have at least one time period when they are both substantially emitting;

(c) detector means disposed to receive light from the first and second light emitter means after it has passed through the object, for generating a resulting detector signal carrying information relating to transmission of the object at both wavelengths;

(d) demodulator means for generating, in response to the detector signal, in a first channel, a first demodulated signal which is a sum of a component proportional to the object'"'"'s transmission at the first wavelength and one or more carrier modulated components, and, in a second channel, a second demodulated signal which is a sum of a component proportional to the object'"'"'s transmission at the second wavelength and one or more carrier modulated components; and

(e) a demodulated signal filter, coupled to said first and second channels, wherein said demodulated signal filter filters out carrier modulated components of the signals from the first and second channels.

2. An instrument as defined in claim 1, additionally comprising detector filter means for filtering frequencies other than around the carrier frequency from the detector signal prior to it being processed by the demodulator.

6. An instrument as defined in claim 3 or 2 or 4 or 5 wherein the demodulated signal filter is a low pass filter which filters signals above the bandwidth of the object'"'"'s transmission signal.

7. An instrument as defined in claim 3 or 2 or 4 or 5 which additionally comprises an interpreter, coupled to said demodulator signal filter, which evaluates the concentration of oxygen from the demodulated signal filter output.

3. An instrument for evaluating the concentration of a constituent in object by measuring the transmission of light of two wavelengths therethrough, comprising:

(a) first and second light emitter means for emitting light at respective, first and second different wavelengths;

(b) modulator/driver means for driving the light emitter means simultaneously with respective first and second sinusoidal carriers which are of the same carrier frequency and having a phase difference other than 0°

degrees and other than an integer multiple of 180°

degrees, wherein said first and second light emitter means have at least one time period when they are both substantially emitting;

(c) detector means disposed to receive light from the first and second light emitter means after it has passed through the object, for generating a resulting detector signal carrying information relating to transmission of the object at both wavelengths;

(d) demodulator means for, in a first channel, multiplying the detector signal with a sinusoidal signal in phase with the first carrier to generate a first demodulated signal which is a sum of a component proportional to the object'"'"'s transmission at the first wavelength and one or more carrier modulated components, and for, in a second channel, multiplying the detector signal with a sinusoidal signal in phase with the second carrier to generate a second demodulated signal which is a sum of a component proportional to the object'"'"'s transmission at the second wavelength and one or more carrier modulated components; and

(e) a demodulated signal filter, coupled to said first and second channels, wherein said demodulated signal filter filters out carrier modulated components of the signals from the first and second channels.

4. An instrument as defined in claim 3 wherein said modulator/driver means comprises means for driving said light emitter means with first and second carriers with a carrier frequency which is greater than the bandwidth of the object'"'"'s transmission signal.

5. An instrument as defined in claim 3, additionally comprising detector filter means for filtering frequencies other than around the carrier frequency from the detector signal prior to it being processed by the demodulator.

8. Apparatus as in claim 3, wherein said detector means comprises means for detecting light which has been applied to a body structure.

9. A method for evaluating the concentration of a constituent in an object, comprising:

(a) simultaneously driving a first and a second light emitter, which emit light at different wavelengths, with respective first and second carriers which vary continuously as a function of time and are of the same carrier frequency and having a phase difference other than 0°

degrees and other than an integer multiple of 180°

degrees, wherein said first and second light emitters have at least one time period when they are both substantially emitting;

(b) directing the light from the emitters through the object;

(c) receiving the light from the emitters at a detector after it has passed through the object, which detector generates a detector signal carrying information relating to transmission of the object at both wavelengths;

(d) demodulating the detector signal to generate, in a first channel, a first demodulated signal which is a sum of a component proportional to the object'"'"'s transmission at the first wavelength and one or more carrier modulated components, and, in a second channel, a second demodulated signal which is a sum of a component proportional to the object'"'"'s transmission at the second wavelength and one or more carrier modulated components;

(e) filtering out carrier modulated components of the first and second demodulated signals and

(f) evaluating the concentration of oxygen from the demodulated and filtered signals.

10. A method for evaluating the oxygen concentration in a body structure of an animal, comprising:

(a) simultaneously driving a first and a second light emitter, which emit light in the red and infra-red regions, respectively, with respective first and second sinusoidal carriers of the same carrier frequency and having a phase difference other than 0°

degrees and other than an integer multiple of 180°

degrees, wherein said first and second light emitters have at least one time period when they are both substantially emitting;

(b) directing the light from the emitters through the body structure;

(c) receiving the light from the emitters at a detector after it has passed through the body structure, which detector generates a detector signal carrying information relating to transmission of the body structure at both wavelengths;

(d) demodulating the detector signal to generate, in a first channel, a first demodulated signal which is a sum of a component proportional to the body structure'"'"'s transmission of red light, and one or more carrier modulated components, and, in a second channel, a second demodulated signal which is a sum of a component proportional to the body structure'"'"'s transmission of infra-red light and one or more carrier modulated components;

(e) filtering out carrier modulated components of the first and second demodulated signals;

(f) evaluating the concentration of oxygen from the demodulated and filtered signals.

11. A method as defined in claim 9 or 10 wherein the first and second light emitters are driven with carriers of a frequency greater than the bandwidth of the object'"'"'s transmission signal.

12. A device for collecting photoplethysmographic data, comprising

means for generating a first and a second signal, said first and second signals being distinguishable by phase;

means for simultaneously applying said first and second signals to a modulating medium, said means for simultaneously applying comprising a first and second emitter, said first and second emitters having at least one time period when they are both substantially emitting;

means for detecting a composite signal at an output of said modulating medium, said modulating medium having a first and a second modulating effect; and

means for generating a first and a second output signal responsive to said composite signal, said first output signal indicating said first modulating effect and said second output signal indicating said second modulating effect, said means for generating comprising means for multiplying at least part of said composite signal with a continuous time-varying signal.

13. A device as in claim 12, wherein said means for generating comprises means for generating first and second signals which are periodic time-varying signals with identical periods.

14. A device as in claim 12, wherein said means for generating comprises means for generating first and second signals which have identical frequency components.

15. A device as in claim 12, wherein said means for detecting comprises a photodiode.

16. A device as in claim 12, wherein said means for detecting a composite signal comprises means for detecting a composite signal comprising a sum of said first modulating effect applied to said first signal and said second modulating effect applied to said second signal.

17. A device as in claim 12, comprising means for determining, in response to a set of photoplethysmographic data, blood gas data.

18. A device as in claim 12, comprising means for determining, in response to a set of photoplethysmographic data, at least one of blood oxygen, blood carbon dioxide, or blood carbon monoxide.

19. A device as in claim 12, wherein said means for generating comprises means for generating at least one comprising a plurality of component signals.

20. A device as in claim 19, wherein said means for generating comprises means for generating at least one signal comprising a plurality of component signals, at least one of said component signals comprising a sum of at least one of a sine wave or, a square wave.

21. A device as in claim 12, wherein said means for applying comprises a plurality of light-emitters.

22. A device as in claim 12, wherein said means for applying comprises a plurality of light-emitters tuned to a plurality of wavelengths.

23. A device as in claim 12, wherein said means for applying comprises means for directing at least one of said first and second signals at animal tissue.

24. A device as in claim 12, wherein said means for applying comprises means for directing at least one of said first and second signals toward at least one of blood, blood vessels, bone marrow, ligament, muscle, or skin.

25. A device as in claim 12, wherein said means for detecting a composite signal comprises means for detecting a composite signal comprising a result of a plurality of modulating effects, wherein at least one of said modulating effects comprises amplitude modulation.

26. A device as in claim 12, wherein said means for detecting a composite signal comprises means for detecting a composite signal comprising a result of a plurality of modulating effects, wherein said modulating effects comprise an amplitude modulation effect which varies with energy wavelength.

27. A device as in claim 12, wherein said means for detecting a composite signal comprises means for detecting a composite signal comprising a result of a plurality of modulating effects, wherein at least one of said modulating effects comprises a time-varying component.

28. A device as in claim 12, wherein said means for detecting a composite signal comprises means for detecting a composite signal comprising a result of a plurality of modulating effects, wherein at least one of said modulating effects comprises a time-varying component which is correlated with a biological process.

29. A device as in claim 12, wherein said means for detecting a composite signal comprises means for detecting a composite signal comprising a result of a plurality of modulating effects, wherein at least one of said modulating effects comprises at least one transmission response of a modulating medium.

30. Apparatus as in claim 12, wherein said means for generating comprises

means for generating said first signal comprising a first sine wave;

and

means for generating said second signal comprising a second sine wave, said second sine wave being delayed 90°

degrees from said first sine wave.

31. Apparatus as in claim 12, wherein said means for detecting comprises

means for sampling said composite signal at a rate higher than a frequency component of said first signal.

32. Apparatus as in claim 12, wherein said means for generating a first and second output signal comprises

means for multiplying at least a part of said composite signal by a continuous time-varying signal corresponding to at least one of said carrier signals;

and

means for filtering.

33. Apparatus as in claim 12, wherein said means for generating a first and second output signal comprises

first means for multiplying said composite signal by said first carrier signal;

first means for filtering a resultant of said first means for multiplying;

second means for multiplying said composite signal by said second carrier signal; and

second means for filtering a resultant of said first means for multiplying.

34. A device for collecting photoplethysmographic data, comprising

means for phase-division multiplexing a plurality of modulating signals;

means for modulating a resultant of said means for phase-division multiplexing; and

means for phase-division demultiplexing said plurality of signals, in response to a resultant of said means for modulating, said means for phase-division demultiplexing comprising means for multiplying at least part of a resultant of said means for modulating with a continuous time-varying signal.

35. A device as in claim 34, wherein said means for phase-division multiplexing comprises means for phase-division multiplexing a plurality of modulating signals which comprise an infrared wavelength modulating signal and a red wavelength modulating signal.

36. A device as in claim 34, wherein said means for phase-division multiplexing and said means for phase-division demultiplexing collectively include means for generating a plurality of carrier signals.

37. A method of collecting photoplethysmographic data, comprising the steps of

generating a first and a second signal, said first and second signals being distinguishable by phase;

simultaneously applying said first and second signals to a modulating medium, including substantially emitting in response to said first signal and substantially emitting in response to said second signal, both during at least one time period;

detecting a composite signal at an output of said modulating medium, said modulating medium having a first and a second modulating effect; and

generating a first and a second output signal responsive to said composite signal, said first output signal indicating said first modulating effect and said second output signal indicating said second modulating effect, said step of generating comprising multiplying at least part of said composite signal with a continuous time-varying signal.

38. A method as in claim 37, wherein said first and second signals are periodic time-varying signals with identical periods.

39. A method as in claim 37, wherein said first and second signals have identical frequency components.

40. A method as in claim 37, wherein said modulating medium comprises animal tissue.

41. A method as in claim 37, wherein said modulating medium comprises at least one of blood, blood vessels, bone marrow, ligament, muscle, or skin.

42. A method as in claim 37, wherein said composite signal comprises a sum of said first modulating effect applied to said first signal and said second modulating effect applied to said second signal.

43. A method as in claim 37, comprising generating a set of photoplethysmographic data comprising blood gas data.

44. A method as in claim 37, comprising generating a set of photoplethysmographic data comprises at least one of:

blood oxygen, blood carbon dioxide or, blood carbon monoxide.

45. A method as in claim 37, wherein at least one of said first and second signals comprises a plurality of component signals.

46. A method as in claim 45, wherein at least one of said component signals comprises a sum of at least one of a sine wave or, a square wave.

47. A method as in claim 37, wherein at least one of said modulating effects comprises amplitude modulation.

48. A method as in claim 37, wherein said modulating effects comprise an amplitude modulation effect which varies with energy wavelength.

49. A method as in claim 37, wherein at least one of said modulating effects comprises a time-varying component.

50. A method as in claim 37, wherein at least one of said modulating effects comprises a time-varying component which is correlated with a biological process.

51. A method as in claim 37, wherein at least one of said modulating effects comprises at least one transmission response of a modulating medium.

52. A method of collecting photoplethysmographic data, comprising the steps of

phase-division multiplexing a plurality of modulating signals;

modulating a resultant of said step of phase-division multiplexing; and

phase-division demultiplexing said plurality of signals, in response to a resultant of said step of modulating, said step of phase-division demultiplexing comprising multiplying at least part of a resultant of said step of modulating with a continuous time-varying signal.

53. A method as in claim 52, wherein said plurality of modulating signals comprises an infrared wavelength modulating signal and a red wavelength modulating signal.

54. A device for collecting photoplethysmographic data, comprising

means for generating a first and a second signal, said first and second signals being distinguishable by phase;

means for applying said first and second signals to a modulating medium, said means for applying comprising a first and second emitter, said first and second emitters having at least one time period when they are both substantially emitting;

means for detecting a composite signal at an output of said modulating medium, said modulating medium having a first and a second modulating effect;

means for sampling said composite signal at a rate higher than a frequency component of said first signal; and

means for generating a first and a second output signal responsive to said composite signal, said first output signal indicating said first modulating effect and said second output signal indicating said second modulating effect.

55. Apparatus as in claim 54, wherein said means for generating a first and second output signal comprises

means for multiplying at least a part of said composite signal by a continuous time-varying signal corresponding to at least one of said carrier signals;

and

means for filtering.

56. Apparatus as in claim 54, wherein said means for generating a first and second output signal comprises

first means for multiplying said composite signal by said first carrier signal;

first means for filtering a resultant of said first means for multiplying;

second means for multiplying said composite signal by said second carrier signal; and

second means for filtering a resultant of said first means for multiplying.