Photoplethysmographics using component-amplitude-division multiplexing

• US 5,349,953 A
• Filed: 03/05/1991
• Issued: 09/27/1994
• Est. Priority Date: 03/05/1991
• Status: Expired due to Term

• Current Assignee: Sensormedics Corporation (Becton, Dickinson & Co)
• Original Assignee: Sensormedics Corporation (Becton, Dickinson & Co)
• Inventors: Smith, Robert, McCarthy, Rex
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): NASSER, ROBERT L
• Application Number:
  US07/665,595
• Time in Patent Office: 1,302 Days
• Field of Search: 128/633-634, 128/664-666, 356/39-41, 251/335
• US Class Current: 600/365
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/417 the bone marrow

Abstract

A plurality of carrier signals, distinguishable by amplitudes of signal components (e.g., frequency components), are respectively applied to a plurality of energy emitters (e.g., infrared and red light emitters). A detector receives the sum of the energy after modulation at each emitter wavelength, e.g. by blood tissue of a patient. An output of the detector is then demultiplexed, whereby a component of modulation at each emitter wavelength may be determined. The carrier signals may comprise time-varying periodic signals with identical frequency and frequency components, such as mixtures of identical sets of pure sine waves. When the number of signal components exceeds the number of emitter wavelengths, sufficient information is provided during demultiplexing to detect and correct errors introduced by ambient light sources and other interference.

Claims

1. A device for collecting photoplethysmographic data, comprising

means for multiplying a mixing matrix and a vector of component signals;

means for applying a plurality of modulating effects to a resultant of said means for multiplying; and

means for multiplying an inverse of said mixing matrix and a resultant of said means for applying.

2. A device as in claim 1, comprising means for determining, in response to a set of photoplethysmographic data, blood gas data.

3. A device as in claim 1, comprising means for determining, in response to a set of photoplethysmographic data, at least one of blood oxygen, blood carbon dioxide, or blood carbon monoxide.

4. A device as in claim 1, wherein said means for multiplying a mixing matrix comprises means for multiplying a square matrix.

5. A device as in claim 1, wherein said means for multiplying a vector of component signals comprises means for multiplying at least one component signals which comprises a sum of at least one of a sine wave, or a square wave.

6. A device as in claim 1, wherein said means for applying comprises a plurality of light-emitters.

7. A device as in claim 1, wherein said means for applying comprises a plurality of light-emitters tuned to a plurality of wavelengths.

8. A device as in claim 1, wherein said means for applying comprises means for directing said resultant at a modulating medium.

9. A device as in claim 1, wherein said means for applying comprises means for directing said resultant at animal tissue.

10. A device as in claim 1, wherein said means for applying comprises means for directing said resultant at a modulating medium comprising at least one of blood, blood vessels, bone marrow, ligament, muscle, or skin.

11. A device as in claim 1, comprising

means for detecting a composite resultant of said means for applying;

and

means for separating said composite resultant into a vector resultant.

12. A device as in claim 11, wherein said means for separating comprises at least one heterodyning element.

13. A device as in claim 11, wherein said means for detecting a composite resultant comprises means for detecting a sum of at least two elements of said vector resultant.

14. A device as in claim 1, wherein said means for applying comprises means for directing said resultant at animal tissue.

15. A device as in claim 1, wherein said means for applying comprises means for directing said resultant at a modulating medium comprising at least one of blood, blood vessels, bone marrow, ligament, muscle, or skin.

16. A device as in claim 1, wherein said means for applying a plurality of modulation effects comprises means for applying at least one amplitude modulation effect.

17. A device as in claim 1, wherein said means for applying a plurality of modulating effects comprises means for applying an amplitude modulation effect which varies with energy wavelength.

18. A device as in claim 1, wherein said means for applying a plurality of modulating effects comprises means for applying at least one modulating effect with a time-varying component.

19. A device as in claim 1, wherein said means for applying a plurality of modulating effects comprises means for applying at least one modulating effect with a time-varying component which is correlated with a biological process.

20. A device as in claim 1, wherein said means for applying a plurality of modulating effects comprises means for applying at least one modulating effect having a transmission response of a modulating medium.

21. A device for collecting photoplethysmographic data, comprising

means for component-amplitude-division multiplexing a plurality of modulating signals;

means for applying a modulation effect to a resultant of said means for component-amplitude-division multiplexing; and

means for component-amplitude-division demultiplexing said plurality of signals;

wherein said means for component-amplitude-division multiplexing and said means for component-amplitude-division demultiplexing collectively comprise means for multiplying a mixing matrix and means for multiplying an inverse of said mixing matrix.

22. A device for collecting photoplethysmographic data, comprising

means for component-amplitude-division multiplexing a plurality of modulating signals;

means for applying a modulation effect to a resultant of said means for component-amplitude-division multiplexing; and

means for component-amplitude-division demultiplexing said plurality of signals;

and means for error detection in response to a resultant of said means for component-amplitude-division demultiplexing.

23. A device as in claim 22, wherein said means for error detection comprises means for generating a plurality of carrier signals using a number of carrier components in excess of a number of carrier signals.

24. A device as in claim 22, wherein said means for error detection comprises means for multiplying a plurality of mixing matrices.

25. A device for collecting photoplethysmographic data, comprising

means for component-amplitude-division multiplexing a plurality of modulating signals;

means for applying a modulation effect to a resultant of said means for component-amplitude-division multiplexing; and

means for component-amplitude-division demultiplexing said plurality of signals;

and means for error correction in response to a resultant of said means for component-amplitude-division demultiplexing.

26. A device as in claim 25, wherein said means for error correction comprises means for majority voting a resultant of component-amplitude-division multiplexing and demultiplexing with a plurality of mixing matrices.

27. A method of collecting photoplethysmographic data, comprising the steps of

multiplying a mixing matrix and a vector of component signals;

applying a plurality of modulating effects to a resultant of said step of multiplying; and

multiplying an inverse of said mixing matrix and a resultant of said step of applying.

28. A method as in claim 27, wherein said step of applying comprises the step of directing said resultant at animal tissues.

29. A method as in claim 27, wherein said step of applying comprises the step of directing said resultant at a modulating medium comprising at least one of the group:

blood, blood vessels, bone marrow, ligament, muscle, skin.

30. A method as in claim 27 wherein comprising determining blood gas data in response to a resultant of said step of multiplying an inverse.

31. A method as in claim 27, comprising determining at least one of blood oxygen, blood carbon dioxide, or blood carbon monoxide.

32. A method as in claim 27, wherein said mixing matrix is a square matrix.

33. A method as in claim 27, wherein at least one of said component signals comprises a sum of at least one of a sine wave, or a square wave.

34. A method as in claim 27, wherein at least one of said modulating effects comprises amplitude modulation.

35. A method as in claim 27, wherein said modulating effects comprise an amplitude modulation effect which varies with energy wavelength.

36. A method as in claim 27, wherein at least one of said modulating effects comprises a time-varying component.

37. A method as in claim 27, wherein at least one of said modulating effects comprises a time-varying component which is correlated with a biological process.

38. A method as in claim 27, wherein at least one of said modulating effects comprises at least one transmission response of a modulating medium.

39. A method as in claim 27, comprising the steps of detecting a composite resultant of said step of applying;

and

separating said composite resultant into a vector resultant.

40. A method as in claim 39, wherein said step of separating comprises at least one hetrodyning step.

41. A method as in claim 39, wherein said composite resultant comprises a sum of at least two elements of said vector resultant.

42. A method of collecting photoplethysmographic data, comprising the steps of

component-amplitude-division multiplexing a plurality of modulating signals;

applying a modulation effect to a resultant of said means for component-amplitude-division multiplexing; and

component-amplitude-division demultiplexing said plurality of signals;

and performing of error detection in response to a resultant of said step of component-amplitude-division demultiplexing.

43. A method of collecting photoplethysmographic data, comprising the steps of

component-amplitude-division multiplexing a plurality of modulating signals;

applying a modulation effect to a resultant of said means for component-amplitude-division multiplexing; and

component-amplitude-division demultiplexing said plurality of signals;

and performing error correction in response to a resultant of said step of component-amplitude-division demultiplexing.

44. A method as in claim 43, wherein said step of error correction comprises majority voting a resultant of component-amplitude-division multiplexing and demultiplexing with a plurality of mixing matrices.