Oral administration of antigens
First Claim
1. An oral vaccine composition for ruminant species said composition comprisingan antigenic composition in an amount effective to induce an immune response in gut-associated lymphoid tissue of said ruminant species in a delivery vehicle consisting essentially of a water swellable hydrogel matrix in the form of pellets having a volume of about 3 to about 75 mm3 and an air-dried density of about 1.1 to about 1.4 g/cc for hydration int he post-ruminal portion of the digestive tract of said species and release of said antigenic composition for contact with the gut-associated lymphoid tissue.
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Accused Products
Abstract
An oral vaccine formulation is provided for stimulation of an immune response in gut-associated lymphoid tissues. The formulation comprises an enzymatically degradable antigen in a hydrogel matrix. In ruminant species, the vaccine formulation, upon oral administration, is formed to pass through the rumen without substantial hydration and then into the post-ruminal portion of the digestive tract where the antigen is released for contact with the gut-associated lymphoid tissue.
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Citations
10 Claims
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1. An oral vaccine composition for ruminant species said composition comprising
an antigenic composition in an amount effective to induce an immune response in gut-associated lymphoid tissue of said ruminant species in a delivery vehicle consisting essentially of a water swellable hydrogel matrix in the form of pellets having a volume of about 3 to about 75 mm3 and an air-dried density of about 1.1 to about 1.4 g/cc for hydration int he post-ruminal portion of the digestive tract of said species and release of said antigenic composition for contact with the gut-associated lymphoid tissue.
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7. An orally administered ruminant vaccine composition comprising a proteolytically degradably antigenic composition in a delivery vehicle consisting essentially of a swellable hydrogel matrix in the form of pellets having a volume of about 3 to about 75 mm3 and an air-dried density of about 1.1 to about 1.4 g/cc, said antigenic composition releasable from said hydrogel matrix upon swelling of the matrix in the post-ruminal portion of the ruminant digestive tract.
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10. A method of vaccinating ruminant species by stimulating the gut-associated lymphoid tissue with an antigenic composition, said method comprising the step of orally administering to said ruminant species a vaccine composition comprising the antigenic composition in a delivery vehicle consisting essentially of a hydrogel matrix in the form of pellets having a volume of about 3 to about 75 mm3 and an air-dried density of about 1.1 to about 1.4 g/cc, swellable in the post-ruminal portion of the digestive tract of the ruminant species with resultant release of the antigenic composition for stimulation of the gut-associated lymphoid tissue of said ruminant species.
Specification