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Oral administration of antigens

  • US 5,352,448 A
  • Filed: 07/20/1992
  • Issued: 10/04/1994
  • Est. Priority Date: 07/20/1992
  • Status: Expired due to Fees
First Claim
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1. An oral vaccine composition for ruminant species said composition comprisingan antigenic composition in an amount effective to induce an immune response in gut-associated lymphoid tissue of said ruminant species in a delivery vehicle consisting essentially of a water swellable hydrogel matrix in the form of pellets having a volume of about 3 to about 75 mm3 and an air-dried density of about 1.1 to about 1.4 g/cc for hydration int he post-ruminal portion of the digestive tract of said species and release of said antigenic composition for contact with the gut-associated lymphoid tissue.

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