Sensing device

• US 5,353,792 A
• Filed: 07/26/1993
• Issued: 10/11/1994
• Est. Priority Date: 09/25/1992
• Status: Expired due to Fees

• Current Assignee: Avl Medical Instruments AG (Roche Holding AG)
• Original Assignee: Avl Medical Instruments AG (Roche Holding AG)
• Inventors: Lubbers, Dietrich W., Karpf, Hellfried
• Primary Examiner(s): Sykes, Angela D.
• Application Number:
  US08/096,409
• Time in Patent Office: 442 Days
• Field of Search: 128/632-635, 128/664-647, 356/39-41, 436/68, 436/172
• US Class Current: 600/311
• CPC Class Codes: A61B 5/14528 invasively
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence

Abstract

In order to simultaneously determine the concentrations of different analytes in several places in a tissue by means of a thin, biocompatible tube or cannula which is inserted into the tissue, the tube is provided with several areas along its length which contain either identical or different optically excitable and readable, preferably luminescence-optical, indicating substances for measuring the local distribution of one parameter, such as O₂ concentration or O₂ partial pressure, or for simultaneous measurement of at least two different parameters, e.g., pO₂, pCO₂ or pH.

Claims

1. An optical sensing device comprising a thin biocompatible tube having a tube wall and a longitudinal axis, said tube being insertable into human or animal tissue, wherein said biocompatible tube operates as a single light guide and has several areas axially displaced which contain different optically excitable and readable indicating substances, and further comprising means for exciting and reading said indicating substances.

3. A sensing device according to claims 1 or 2, wherein said tissue parameter is the O₂ concentration or the O₂ partial pressure.

4. A sensing device according to claims 1 or 2, wherein said at least two tissue parameters belong to the pO₂, PCO₂, pH group.

5. A sensing device according to claims 1 or 2, wherein said biocompatible tube is a microdialysis tube.

6. A sensing device according to claims 1 or 2, wherein said indicating substances are luminescence-optical substances.

7. A sensing device according to claims 1 or 2, wherein said tube is surrounded by a hollow needle, which is removable after said tube is inserted into human or animal tissue.

8. A sensing device according to claims 1 or 2, wherein one end of said biocompatible tube located in said tissue is mirror-faced and the other end is used for feeding in excitation radiation and picking up measurement radiation.

9. A sensing device according to claims 1 or 2, wherein said biocompatible tube is threadable through said tissue having both ends of said tube projecting from a tissue surface, one end of said tube being available for feeding in excitation radiation and the other end for picking up measurement radiation.

10. A sensing device according to claims 1 or 2, wherein at least one free end of said tube is provided with an optode foil in contact with said tissue surface for measuring the surface concentration of a given species.

11. A sensing device according to claims 1 or 2 comprising a probe with at least one mirror face inclined towards said longitudinal axis of said tube by about 45°

, wherein said probe is insertable into said tube in axial direction.

12. A sensing device according to claim 11, wherein each said mirror face is a dichroitic mirror.

13. A sensing device according to claims 1 or 2, wherein said biocompatible tube is transparent in at least one area.

14. A sensing device according to claims 1 or 2, comprising means for contact-free feeding in excitation radiation and pick-up measurement radiation to said biocompatible tube, wherein said means includes an evaluation unit.

15. A sensing device according to claims 1 or 2, comprising indicating substances with an excitation and emission wavelength of about 600 to 1200 nm.

16. A sensing device according to claims 1 or 2, wherein at least parts of said biocompatible tube are made of material accumulating a sample substance to be measured.

2. An optical sensing device comprising a thin biocompatible tube having a tube wall and a longitudinal axis, said tube being insertable into human or animal tissue, wherein said tube is provided with a liquid, gel-like or solid tube filling, wherein the refractive index of said tube wall is lower than the refractive index of said tube filling, so that said tube filling operates as a single light guide and wherein said tube has several areas axially displaced which contain different, optically excitable and readable indicating substances, and further comprising means for exciting and reading said indicating substances.