Injector for delivering fluid to internal target tissue

• US 5,354,287 A
• Filed: 01/16/1991
• Issued: 10/11/1994
• Est. Priority Date: 01/16/1991
• Status: Expired due to Term

• Current Assignee: Ranbaxy Pharmaceuticals Incorporated (Daiichi Sankyo Company Limited)
• Original Assignee: Senetek Plc
• Inventors: Wacks, Jonathan L.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): STRIGHT, RONALD K
• Application Number:
  US07/641,752
• Time in Patent Office: 1,364 Days
• Field of Search: 604/232, 604/234, 604/194, 604/195, 604/196, 604/202, 604/200, 604/213, 604/110, 604/156, 604/201, 604/197, 604/121, 604/123-125, 604/130, 604/137-139, 604/403 , 604/411-416, 604/205, 604/206, 604/233, 604/235, 604/236, 604/237, 604/239, 604/240, 604/144, 604/146, 604/171, 128/DIG. 1, 222/326, 222/386, 141/27, 141/329, 141/330, 141/383, 141/385, 141/386
• US Class Current: 604/232
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/2407 from the rear
• CPC Class Codes: A61M 2005/247 with fixed or steady piercing means, e.g. piercing under movement of ampoule
• CPC Class Codes: A61M 2005/3231 Proximal end of needle captured or embedded inside piston head, e.g. by friction or hooks
• CPC Class Codes: A61M 2205/195 by the needle tip shape
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/322 Retractable needles, i.e. disconnected from and withdrawn into the syringe barrel by the piston devices for protecting guide needles in combination with catheters A61M25/0612
• CPC Class Codes: A61M 5/3291 Shafts with additional lateral openings
• CPC Class Codes: Y10S 128/01 Motorized syringe

Abstract

An injector for delivering fluid to a preselected internal target tissue while avoiding fluid exposure to surface tissue. A needle housing assembly is concealed within a cartridge having a puncturable end cap and an ampule is also disposed within the cartridge separate from the needle housing assembly. The cartridge has a cylindrical bore which widens at one end such that the needle housing assembly which has walls while located within the narrower portion of the cylindrical bore prevents the ampule from being punctured by a hollow injection needle supported by the needle housing assembly. When the ampule is propelled toward the needle housing assembly with a plunger, the needle housing assembly enters the widened portion of the cylindrical bore, allowing its walls to be separated such that the hollow injection needle extends into the ampule allowing the fluid to be delivered from the ampule through the hollow injection needle to the internal target tissue.

Claims

1. A fluid injector actuated by a plunger, said fluid injector comprising:

(A) a tubular cartridge having an upper end and a lower end, said cartridge having an interior bore wall which widens at said lower end of said cartridge to form a needle housing assembly residence chamber for receiving a needle housing assembly;

(B) a puncturable end cap sealing said lower end of said cartridge;

(C) an ampule slidably disposed within the upper end of said cartridge bore wall, said ampule having an upper end and a lower end and being suitable for storing a fluid charge to be expelled therefrom;

(D) a piston slidably seated within said ampule and engageable by said plunger from said upper end of said ampule;

(E) a puncturable ampule end stopper rigidly attached to and sealing said lower end of said ampule; and

(F) a needle housing assembly slidably disposed within said upper end of said cartridge below said ampule, said needle housing assembly comprising;

a housing having a housing bottom and flexible upstanding housing walls attached to the periphery of said housing bottom, said housing walls extending toward said lower end of said ampule and having upper edges thereon,

a hollow injection needle extending through and rigidly engaged by said housing bottom and having an internal section, and an external section, said internal section of said hollow injection needle extending from said housing bottom, upwardly within said housing walls, toward said puncturable ampule end stopper, and said external section of said hollow injection needle extending from said housing bottom downwardly toward said puncturable end cap of said cartridge, said needle being within said cartridge between said puncturable ampule end stopper and said puncturable end cap,

the upper edges of said housing walls being engageable with said lower end of said ampule as said ampule slides downwardly within said cartridge bore, whereby actuation by said plunger moves said ampule downwardly within said interior bore wall in said upper end of said cartridge toward said lower end of said cartridge thus engaging said upper edges of said housing walls and moving said needle housing assembly from said upper end of said cartridge into said needle housing assembly residence chamber at said lower end of said cartridge causing said external section of said hollow injection needle to protrude through said puncturable end cap and allowing said flexible housing walls to expand outwardly in said needle housing assembly residence chamber, the further downward movement of said ampule causing the internal section of said hollow injection needle to pass through said puncturable ampule end stopper thereby allowing fluid to be injected outwardly through said hollow injection needle.

2. A fluid injector in accordance with claim 1 wherein said ampule further comprises a first cylindrical portion, a second cylindrical portion adjacent to and narrower than said first portion, and a third cylindrical portion adjacent to and wider than said second portion.

3. A fluid injector in accordance with claim 2 wherein said upper ends of said housing walls engageable with said ampule further comprises locking means for irreversibly locking said needle housing assembly to said ampule at said third cylindrical portion of said ampule when said needle housing assembly and said ampule are engaged.

4. A fluid injector in accordance with claim 3 wherein said housing walls further comprise needle assembly housing lips at said upper edges of said housing walls, said lips engageable with said ampule.

5. A fluid injector in accordance with claim 1 wherein said interior bore wall is cylindrical.

6. A fluid injector in accordance with claim 1 further comprising a needle guide disposed in said puncturable end cap.

7. A fluid injector in accordance with claim 1 wherein said ampule has a circumferential recess or groove located adjacent its lower end and wherein the upper edges of said housing walls have inwardly extending sections for engaging the lower end of said ampule.

8. A fluid injector in accordance with claim 1 wherein said piston further comprises means for reversibly engaging said plunger.

9. A fluid injector in accordance with claim 1 wherein said upper end of said tubular cartridge receives an assembly which comprises a spring for engaging said plunger for actuation to move said ampule within said interior bore wall.

10. A fluid injector in accordance with claim 1 wherein said external section of said hollow injection needle is retractable from said puncturable end cap with the retraction of said needle housing assembly within said cartridge.

11. A fluid injector in accordance with claim 1 wherein said ampule moves downwardly within said housing of said needle housing assembly causing the internal section of said hollow injection needle to pass through said puncturable ampule end stopper.

12. An injector positionable on external tissue for delivering fluid into a preselected internal target tissue while avoiding fluid exposure to the surface tissue comprising:

a tubular cartridge, having a first end and a second end, said cartridge having an interior bore wall which is widened at said second end of said cartridge;

a hollow injection needle positioned axially within said tubular cartridge, said hollow injection needle having an inwardly positioned end directed toward said upper end of said tubular cartridge and an external end directed toward said lower end of said tubular cartridge;

a housing supporting said hollow injection needle positioned axially within said tubular cartridge, said housing being slidable in said tubular cartridge and having expandable walls along side said inwardly positioned end of said hollow injection needle;

an ampule containing said fluid positioned in said tubular cartridge above said hollow injection needle, said ampule having a puncturable end stopper facing the inwardly positioned end of said hollow injection needle;

means for propelling said housing supporting said hollow injection needle together with said ampule within said tubular cartridge causing said external end of said needle to puncture the surface tissue and extend outward from said cartridge through the surface tissue into the target tissue;

means for further propelling said ampule within said cartridge in the direction of said hollow injection needle causing the walls of said housing to expand in the widened lower end of said tubular cartridge and said puncturable end stopper on said ampule to be punctured by said inwardly positioned end of said hollow injection needle allowing said inwardly end to extend into said ampule; and

means for expelling said fluid from said ampule through said external end of said hollow injection needle into said internal target tissue.

13. An injector in accordance with claim 12 further comprising means for retracting said housing supporting said hollow injection needle within said tubular cartridge causing said external end of said needle to retract from the surface tissue and into said cartridge.

14. A fluid injector comprising:

(A) a tubular cartridge, having a first end and a second end, said cartridge having an interior bore wall which is widened at said second end of said cartridge to form a needle housing assembly residence chamber for reversibly receiving a needle housing assembly, and a puncturable end cap, said end cap sealing said second end of said cartridge and having a needle guide disposed therein;

(B) an ampule disposed within said interior bore wall, said ampule having a first elongated cylindrical portion, a second cylindrical portion adjacent to and narrower than said first portion, and a third cylindrical portion adjacent to and wider than said second portion, said ampule being suitable for storing a fluid charge to be expelled therefrom;

(C) a piston slidably seated within said first portion of said ampule;

(D) a plunger engageable with said piston for exerting a force against said piston;

(E) a puncturable ampule end stopper rigidly attached to and sealing said third portion of said ampule; and

(F) a needle housing assembly disposed in said interior bore of said cartridge said needle housing assembly comprising;

a housing,

a hollow injection needle rigidly attached to said housing and having an internal end and an external end, said internal end of said needle extending through said needle housing assembly toward said puncturable ampule end stopper, and said external end of said hollow injection needle extending toward said puncturable end cap of said cartridge, said needle being within said cartridge between said puncturable ampule end stopper and said puncturable end cap,

said housing having locking means for irreversibly locking said needle housing assembly to said ampule when said needle housing assembly and said ampule are brought together upon said plunger exerting a force against said piston moving said ampule and said housing toward said second end of said cartridge wherein the locking means of said housing expand outwardly in the widened interior bore wall of said second end to lock said housing with said ampule.