Apparatus and method for cardiac pacing responsive to patient position

• US 5,354,317 A
• Filed: 04/03/1992
• Issued: 10/11/1994
• Est. Priority Date: 04/03/1992
• Status: Expired due to Fees

• Current Assignee: Advanced Medical Optics Incorporated (Johnson & Johnson)
• Original Assignee: Intermedics Incorporated
• Inventors: Alt, Eckhard
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US07/863,166
• Time in Patent Office: 921 Days
• Field of Search: 128/419 PG, 128/421, 128/782
• US Class Current: 607/19
• CPC Class Codes: A61N 1/36535 controlled by body position or posture
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration

Abstract

An implantable variable rate cardiac pacemaker adaptive to patient exercise has a sensor responsive to each of several preselected different static physical positions of the implant patient to produce electrical output signals uniquely representative of the different physical positions. The pulse generator of the pacemaker is responsive to each output signal of the sensor to generate pacing pulses at a rate different from the rates generated in response to each of the other output signals of the sensor, so that each preselected different physical position has its own representative pacing pulse rate for stimulation of the patient'"'"'s heart. The generator includes a rate control section adapted to respond to a change by the implant patient from one preselected physical position to another by producing a predetermined pattern of transition from the rate representative of the old position to the rate representative of the new position. In circumstances where the old position is a supine, reclining or prone position and the new position is standing, the rate control is effected to cause a transition from the old rate (for lying or seated reclining position) to the new rate (for the standing position) by first abruptly increasing the rate to a magnitude substantially exceeding the desired new rate and then gradually reducing the magnitude to the new rate. In other position changes, a smooth transition is effected between the old and new rates.

Claims

1. A cardiac pacing device adapted to be implanted in a patient and to have a variable pacing rate adaptive to patient exercise, comprising:

sensor means adapted to respond to a plurality of preselected distinct and different static physical positions of the patient for producing electrical output signals uniquely representative of the distinct and different physical positions,

pulse generator means responsive to each said uniquely representative electrical output signal produced by said sensor means for generating pacing pulses at a rate which is different from the rates generated in response to each of the other uniquely representative electrical output signals produced by said sensor means, so that each preselected distinct and different physical position among said plurality of preselected distinct and different static physical positions of the patient has its own representative pacing pulse rate, to stimulate the patient'"'"'s heart, said pulse generator means including transitioning means responsive to a change from a static physical position of lying to a static physical position of standing for abruptly increasing the rate to a value exceeding the rate representative of standing and for thereafter gradually reducing the rate to the rate representative of standing.

2. The cardiac pacing device of claim 1 wherein:

said sensor means comprises an accelerometer.

3. The cardiac pacing device of claim 2, further including:

a case in which said pulse generator means is housed, and means for mechanically isolating the accelerometer from the case to render it unresponsive to pressure on the case.

4. The cardiac pacing device of claim 2, further including:

a case in which said pulse generator means is housed, and

a second case in which said accelerometer is housed in mechanical isolation for implantation in the patient separately from the case for said pulse generator means.

5. The cardiac pacing device of claim 2, wherein:

said accelerometer comprises a hybrid semiconductor structure.

6. The cardiac pacing device of claim 5, wherein:

said accelerometer comprises a composition selected from the group consisting of piezoelectric, piezocapacitive and piezoresistive material.

7. The cardiac pacing device of claim 2, wherein:

said sensor means includes a silicon integrated circuit containing said accelerometer.

8. The cardiac pacing device of claim 1, wherein:

said transitioning means includes hysteresis means responsive to a change in the patient'"'"'s physical position from standing to another static physical position for smoothly varying the rate from the rate representative of standing to the rate representative of said another static physical position.

13. The method of claim 1, further including:

sensing a change in physical position of the patient from one to another of said preselected static physical positions, and

smoothly transitioning the pacing rate of the pacemaker from the rate calibrated for said one position to the rate calibrated for said another position.

9. A method of providing an implantable cardiac pacemaker sensitive to certain preselected relatively static physical positions of the patient in whom the pacemaker is implanted, which comprises:

providing a mechanoelectrical transducer which produces a plurality of distinct and different electrical outputs in response to and respectively uniquely representative of a plurality of distinct and different static orientations of the transducer relative to a horizontal plane,

providing a programmable pulse generator for implantation with and electrical connection to the transducer so that each of the distinct and different electrical outputs of the transducer representative of distinct and different static orientations of the transducer causes the pulse generator to generate pacing pulses at different rates uniquely corresponding to the different electrical outputs of the transducer and, thereby, to the different orientations of the transducer,

calibrating the different rates for the different electrical outputs to correspond to a desired heart rate for each preselected static physical position of the implant patient, based on the orientation of the transducer when implanted in the patient, so that the rate at which pacing pulses are generated depends at least in part on the patient'"'"'s static physical position and a change in pacing pulse rate occurs when the patient changes from one physical position to another dictating a different rate, and

implementing the pacemaker to perform an algorithm to recognize the electrical output produced by the transducer when the patient changes position from supine to upright as distinguished from other forms of activity of the patient, and to respond when such recognition occurs to abruptly increase the rate to a level above the normal rate for the upright position with a gradual return to said normal rate, to compensate for the physiologic drop in cardiac stroke volume of the patient in such change of positions.

10. The method of claim 9, including implementing the pacemaker for automatically performing the step of calibrating.

11. A method of controlling the pacing rate of an implantable cardiac pacemaker based in part on a plurality of preselected relatively static physical positions of a patient in which the pacemaker is implanted, comprising the pacemaker-implemented steps of:

sensing each of a plurality of preselected distinct and different static physical positions of the patient,

developing a plurality of distinct and different electrical signals having a one-to-one correspondence to the sensed plurality of preselected distinct and different static physical positions of the patient,

separately employing each of said plurality of distinct and different electrical signals as a pacing rate control signal for the pacemaker according to the sensed static physical positions of the patient at different points in time, and

automatically calibrating the pacemaker to generate different pacing rates for each of said different electrical signals employed as a pacing rate control signal to provide a desired heart rate for each preselected static physical position of the patient as the patient assumes each of the preselected static physical positions.

12. The method of claim 11, further including:

sensing a change in physical position of the patient from a supine position to an upright position, and

abruptly increasing the pacing rate to a level above a predetermined normal pacing rate for the upright position and gradually returning to said normal rate, to compensate for the physiologic drop in cardiac stroke volume of the patient in said change in physical position from the supine position to the upright position.