Laser induced platelet inhibition
First Claim
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1. A method for inhibiting platelet adhesion to a mammalian blood vessel surface having a known thermal relaxation time, said method comprising the steps of:
- a. inserting, into a blood vessel, an elongate liquid core laser catheter having a liquid carrying lumen extending longitudinally therethrough such that a flow of laser transmitting liquid may be infused through said catheter;
b. passing a laser transmitting liquid through the liquid carrying lumen of said catheter such that said liquid passes through said catheter and into contact with said blood vessel surface;
c. causing a pulse of laser energy to be transmitted into said liquid passing through the lumen of said catheter such that said liquid will carry said laser energy into contact with said blood vessel wall, thereby causing irradiation of said blood vessel wall; and
d. maintaining the pulse duration of said pulse of laser energy such that the elapsed time from the beginning of said pulse to the end of said pulse is less than the thermal relaxation time of the irradiated blood vessel surface.
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Abstract
A method for preventing platelet adhesion to a vascular surface in a mammal, which includes irradiating the vascular surface with a pulse of laser energy having a pulse duration less than the thermal relaxation time of the irradiated vascular surface, wherein lasar energy is delivered to said vascular surface via radiographic contrast material.
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Citations
35 Claims
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1. A method for inhibiting platelet adhesion to a mammalian blood vessel surface having a known thermal relaxation time, said method comprising the steps of:
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a. inserting, into a blood vessel, an elongate liquid core laser catheter having a liquid carrying lumen extending longitudinally therethrough such that a flow of laser transmitting liquid may be infused through said catheter; b. passing a laser transmitting liquid through the liquid carrying lumen of said catheter such that said liquid passes through said catheter and into contact with said blood vessel surface; c. causing a pulse of laser energy to be transmitted into said liquid passing through the lumen of said catheter such that said liquid will carry said laser energy into contact with said blood vessel wall, thereby causing irradiation of said blood vessel wall; and d. maintaining the pulse duration of said pulse of laser energy such that the elapsed time from the beginning of said pulse to the end of said pulse is less than the thermal relaxation time of the irradiated blood vessel surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28)
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27. A method for treating at least one artery involved in acute myocardial infarction wherein said artery has a known thermal relaxation time, said method comprising the steps of:
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a. inserting, into said artery, an elongate liquid core laser catheter having a liquid carrying lumen extending longitudinally therethrough such that a flow of laser transmitting liquid may be infused through said catheter; b. passing a laser transmitting liquid through the liquid carrying lumen of said catheter such that said liquid passes through said catheter and into contact with a surface of said artery; c. causing a pulse of laser energy to be transmitted into said liquid passing through the lumen of said catheter such that said liquid will carry said laser energy into contact with said artery surface, thereby causing irradiation of said artery surface; and d. maintaining the pulse duration of said pulse of laser energy such that the elapsed time from the beginning of said pulse to the end of said pulse is less than the thermal relaxation time of the irradiated artery surface.
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29. A method for treating at least one artery involved in unstable angina wherein said artery has a known thermal relaxation time, said method comprising the steps of:
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a. inserting, into said artery, an elongate liquid core laser catheter having a liquid carrying lumen extending longitudinally therethrough such that a flow of laser transmitting liquid may be infused through said catheter; b. passing a laser transmitting liquid through the liquid carrying lumen of said catheter such that said liquid passes through said catheter and into contact with a surface of said artery; c. causing a pulse of laser energy to be transmitted into said liquid passing through the lumen of said catheter such that said liquid will carry said laser energy into contact with said artery surfaces, thereby causing irradiation of said artery surface; and
,d. maintaining the pulse duration of said pulse of laser energy such that the elapsed time from the beginning of said pulse to the end of said pulse is less than the thermal relaxation time of the irradiated artery surface. - View Dependent Claims (30)
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31. A method for preventing arterial occlusion following balloon angioplasty wherein said artery has a known thermal relaxation time, said method comprising the steps of:
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a. inserting, into said artery, an elongate liquid core laser catheter having a liquid carrying lumen extending longitudinally therethrough such that a flow of laser transmitting liquid may be infused through said catheter; b. passing a laser transmitting liquid through the liquid carrying lumen of said catheter such that said liquid passes through said catheter and into contact with a surface of said artery; c. causing a pulse of laser energy to be transmitted into said liquid passing through the lumen of said catheter such that said liquid will carry said laser energy into contact with said artery surfaces, thereby causing irradiation of said artery surface; and
,d. maintaining the pulse duration of said pulse of laser energy such that the elapsed time from the beginning of said pulse to the end of said pulse is less than the thermal relaxation time of the irradiated artery surface. - View Dependent Claims (32)
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33. A method for delivering laser energy to a treatment site within a mammalian body through an elongate laser catheter having a hollow lumen extending therethrough, said method comprising the steps of:
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a. inserting, into said body, an elongate liquid core laser catheter having a liquid carrying lumen extending longitudinally therethrough such that a flow of laser transmitting liquid may be infused through said catheter; b. passing a laser transmitting liquid through the liquid carrying lumen of said catheter such that said liquid passes through said catheter and into contact with said treatment site within said body; c. causing a pulse of laser energy to be transmitted into said liquid passing through the lumen of said catheter such that said liquid will carry said laser energy into contact with said treatment site within said body, thereby causing irradiation of said treatment site; and
,d. maintaining the pulse duration of said pulse of laser energy such that the elapsed time from the beginning of said pulse to the end of said pulse is less than the thermal relaxation time of the irradiated treatment site within said body. - View Dependent Claims (34, 35)
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Specification