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Process for preparing micronized polypeptide drugs

  • US 5,354,562 A
  • Filed: 02/16/1993
  • Issued: 10/11/1994
  • Est. Priority Date: 01/21/1992
  • Status: Expired due to Fees
First Claim
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1. In a process for preparing a micronized polypeptide drug comprising lyophilizing a solution of the drug in a solvent and milling the lyophilized drug in a fluid energy mill using a pressurized gas to form a powder, the improvement comprising using a pure inert gas filtered to remove particles greater than about 0.1 μ

  • m and the improvement wherein the parts of the mill that are contacted by the pressurized gas in which the polypeptide drug is being carried are not substantially abraded by said drug-carrying gas whereby the insoluble contaminants in the micronized polypeptide drug comprise less than 2% by weight of the polypeptide drug.

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