Methods for treatment of sepsis using branch chain amino acids

• US 5,354,771 A
• Filed: 06/24/1993
• Issued: 10/11/1994
• Est. Priority Date: 09/30/1991
• Status: Expired due to Term

• Current Assignee: Johns Hopkins University
• Original Assignee: Johns Hopkins University
• Inventors: Walser, MacKenzie
• Primary Examiner(s): Hook, Gregory
• Application Number:
  US08/082,144
• Time in Patent Office: 474 Days
• Field of Search: 514/557, 514/561, 514/921, 514/610, 514/400
• US Class Current: 514/400
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/205 Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine

Abstract

Methods for treatment of free-radical-mediated tissue injury, particularly sepsis, are provided wherein compositions containing at least one keto analog of a branched-chain amino acid are administered. The composition is administered orally or parenterally, preferably in frequent or continuous dosages. Preferred forms of the keto analogs are their ornithine, arginine, or sodium salts.

Claims

1. A method for treatment of sepsis in a patient in need thereof which comprises orally or parenterally administering to said patient a composition comprising at least one keto analog of a branched-chain essential amino acid selected from the group consisting of valine, leucine, and isoleucine in an amount effective to treat sepsis.

2. The method of claim 1 in form for parenteral administration, the composition being in the form of a sterilized isotonic aqueous solution.

3. The method of claim 1 wherein each of the keto analogs is in the form of its salt, the counterion selected from the group consisting of ornithine, lysine, arginine, histidine, calcium, and sodium.

4. The method of claim 3 wherein the parenteral administration is intravenous and continuous to keep circulating ketoacid levels elevated.

5. The method of claim 4 wherein the counterion is sodium.

6. The method of claim 3 wherein the oral administration is frequent to keep circulating ketoacid levels elevated.

7. The method of claim 6 wherein the counterion is ornithine or arginine.