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Protein-polycation conjugates

  • US 5,354,844 A
  • Filed: 03/09/1990
  • Issued: 10/11/1994
  • Est. Priority Date: 03/16/1989
  • Status: Expired due to Term
First Claim
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1. A transferrin-polycation conjugate which is capable of forming a complex with a nucleic acid coding for a protein, wherein said conjugate when complexed with said nucleic acid, is capable of being internalized into erythroblasts by endocytosis mediated by the transferrin receptor, wherein said protein is capable of being expressed after said complex is internalized into erythroblasts, wherein the molar ratio of transferrin to polycation is 10:

  • 1 to 1;

    4, and wherein said polycation is a protamine or a homologous polypeptide comprising positively charged amino acids.

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