Method and apparatus for treatment of atrial fibrillation and flutter

• US 5,356,425 A
• Filed: 06/24/1993
• Issued: 10/18/1994
• Est. Priority Date: 06/30/1992
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Bardy, Gust H., Mehra, Rahul
• Primary Examiner(s): MANUEL, GEORGE C
• Application Number:
  US08/082,327
• Time in Patent Office: 481 Days
• Field of Search: 607/4, 607/5, 607/6, 607/9, 607/14
• US Class Current: 607/14
• CPC Class Codes: A61N 1/3621 for treating or preventing abnormally high heart rate
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

A stimulator for applying stimulus pulses to the AV nodal fat pad in response to sensed atrial rate exceeding a predetermined rate, in order to reduce the ventricular rate. The device also includes a cardiac pacemaker which serves to pace the ventricle in the event that the ventricular rate is lowered below a pacing rate, and provides for feedback control of the stimulus parameters applied to the AV nodal fat pad, as a function of the determined effect of the stimulus pulses on the ventricular rate.

Claims

1. A method of electrical stimulation, comprising:

placing an electrode in an appropriate location for stimulating the AV nodal fat pad of a human heart;

defining a first heart rate;

sensing the rate at which said human heart is beating; and

providing said stimulus pulses to said electrode, synchronized to depolarizations of a chamber of said human heart in response to the rate at which said heart is beating exceeding said first heart rate.

2. A method according to claim 1 wherein said pulse providing step comprises delivering said stimulus pulses during refractory periods following depolarizations of said chamber of said human heart.

3. A method according to claim 1 or claim 2 further comprising the steps of:

defining a second heart rate below said first heart rate; and

pacing said human heart when the rate at which said human heart is beating falls below said second heart rate.

4. A method according to claim 3 further comprising the step of defining a third heart rate above said second heart rate, and wherein said step of providing said stimulus pulses to said electrode is continued only while the rate of said human heart is above said third rate.

5. A method according to claim 1, further comprising the steps of;

determining the effect of said stimulus pulses on the rate at which said human heart is beating; and

adjusting the amplitude of said stimulus pulses as a function of the determined effect of said stimulus pulses.

6. A method according to claim 5 wherein said step of determining the effect of said stimulus pulses on the rate of said human heart comprises comparing the rate of said human heart following delivery of said stimulus pulses to a predetermined upper rate and wherein said adjusting step comprises incrementing the amplitude of said stimulus pulses responsive to the failure of said stimulus pulses to reduce the rate of said human heart below said upper rate.

7. A method according to claim 6 wherein said step of determining the effect of said stimulus pulses on the rate of said human heart comprises comparing the rate of said human heart following delivery of said stimulus pulses to an intermediate heart rate less than said upper rate and wherein said adjusting step comprises decrementing the amplitude of said stimulus pulses in response to delivery of said stimulus pulses resulting in a reduction in a rate of said human heart below said intermediate rate.

8. An electrical medical stimulator, comprising:

electrode means for delivery of electrical stimulation to the fat pad associated with the AV node of a human heart;

pulse generator means for generating stimulus pulses and for providing said stimulus pulses to said electrode means;

means for sensing the rate at which said human heart is beating;

means for defining a first heart rate; and

initiating means responsive to said sensing means for initiating the operation of said pulse generator means in response to the rate of said human heart exceeding said first heart rate;

means for defining a second heart rate;

means for pacing the ventricle of said human heart when the rate of said human heart falls below said second heart rate; and

means for defining a third heart rate above said second rate and below said first rate, such that said pulse generator means provides said stimulus pulses to said electrode means only when the rate of said human heart is above said third rate.

9. An electrical medical stimulator, comprising:

electrode means for delivery of electrical stimulation to the fat pad associated with the AV node of a human heart;

means for sensing depolarizations of a chamber of said human heart to determine the rate at which said human heart is beating;

pulse generator means responsive to said sensing means for generating stimulus pulses and for providing said stimulus pulses to said electrode means during the refractory period of said chamber of said heart;

means for defining a first heart rate; and

initiating means responsive to said sensing means for initiating the operation of said pulse generator means in response to the rate of said human heart exceeding said first heart rate.

10. An electrical medical stimulator, comprising:

electrode means for delivery of electrical stimulation to the fat pad associated with the AV node of a human heart;

means for sensing depolarizations of a chamber of said human heart to determine the rate at which said human heart is beating;

pulse generator means for generating stimulus pulses and for providing said stimulus pulses to said electrode means;

means for defining a first heart rate;

initiating means responsive to said sensing means for initiating the operation of said pulse generator means in response to the rate of said human heart exceeding said first heart rate; and

means for sensing a physiologic parameter other than heart rate; and

wherein said means for defining said first heart rate comprises means for defining said first heart rate as a function of said physiologic parameter.

11. A stimulator according to claim 8 or claim 9 or claim 10, further comprising means responsive to said sensing means and to said pulse generator means for determining the effect of said stimulus pulses on the rate of said human heart and means for adjusting the energy of said stimulus pulses as a function of the detected effect of said stimulus pulses.

12. A stimulator according to claim 11 wherein said determining means comprises means for comparing the rate of said human heart following delivery of said stimulus pulses to a predetermined upper rate, and wherein said adjusting means is responsive to the failure of delivered stimulus pulses to reduce the heart rate of said human heart below said upper rate and in response thereto increments the energy of said stimulus pulses.

13. A stimulator according to claim 12 further comprising means for defining an intermediate rate below said upper rate and wherein said determining means compares the rate of said human heart following delivery of said stimulus pulses to said intermediate heart rate and, in response to delivery of said stimulus pulses resulting in a reduction of the rate of said human heart below said intermediate rate decrements the energy of said stimulus pulses.

14. A stimulator according to claim 13 further comprising means for defining a pacing rate below said intermediate rate and means for pacing said human heart when the rate of said human heart falls below said pacing rate.

16. A stimulator according to claim 8 or claim 9 or claim 10 or claim 15 wherein said means for sensing the rate of said human heart comprises means for sensing ventricle depolarizations of said human heart.

17. A simulator according to claim 9 or claim 10 or claim 15 further comprising means for defining a second heart rate and means for pacing said human heart when said sensed heart rate falls below a second heart rate.

18. A stimulator according to claim 17 wherein said pacing means comprises means for pacing the ventricle of said human heart.

19. A stimulator according to claim 9 or claim 10 or claim 15 further comprising means for defining a third heart rate above said second rate, wherein said pulse generator means is responsive to said means for defining said third heart rate, such that said pulse generator means provides said stimulus pulses to said electrode means only when the rate of said human heart is above said third heart rate.

20. A stimulator according to claim 19 wherein said means for defining said second heart rate and said third heart rate comprise means for defining said second and third heart rates as a function of said physiologic parameter.

21. A stimulator according to claim 9 or claim 10 or claim 15, further comprising means for defining a second rate below said first rate and further comprising deactivating means responsive to said sensing means for terminating the operation of said pulse generator means in response to the rate of said heart persistently falling below said second rate.

15. An electrical medical stimulator, comprising:

electrode means for delivery of electrical stimulation to the fat pad associated with the AV node of a human heart;

means for sensing depolarization of a chamber of said human heart to determine the rate at which said human heart is beating;

pulse generator means responsive to said sensing means for generating stimulus pulses and for providing said stimulus pulses to said electrode means;

means for defining a first heart rate;

means for defining an acceptable range of heart rates;

initiating means responsive to said sensing means for enabling the operation of said pulse generator means in response to the rate of said human heart exceeding said first heart rate; and

means responsive to said sensing means and to said pulse generator means for determining the effect of said stimulus pulses on the rate of said human heart and means for adjusting the energy of said stimulus pulses, while said pulse generator is enabled, as a function of the determined effect of said stimulus pulses, to maintain said heart rate within said acceptable range of heart rates.