Materials for living hard tissue replacements

• US 5,356,436 A
• Filed: 04/21/1992
• Issued: 10/18/1994
• Est. Priority Date: 06/06/1989
• Status: Expired due to Fees

• Current Assignee: TDK Corporation
• Original Assignee: TDK Corporation
• Inventors: Nakajima, Shinya, Nonami, Tohru, Noma, Hiroyasu
• Primary Examiner(s): Green, Randall L.
• Assistant Examiner(s): BRITTINGHAM, DEBRA
• Application Number:
  US07/872,949
• Time in Patent Office: 910 Days
• Field of Search: 623/16, 623/66, 623/901, 106/35, 501/1, 501/123, 501/154, 433/228.1
• US Class Current: 501/141
• CPC Class Codes: A61L 27/10 Ceramics or glasses
• CPC Class Codes: C04B 35/22 rich in calcium oxide , e.g. wollastonite C04B35/195 takes precedence
• CPC Class Codes: Y10S 623/901 Method of manufacturing prosthetic device

Abstract

The materials for living hard tissue replacements of the present invention comprise a ceramic material which contain Cao and SiO₂ as essential components, and MgO as an optional components, are substantially free from calcium phosphate and are capable of forming a compound based on calcium phosphate by contact with an aqueous solution containing phosphorus, and show high biological affinity.

Claims

1. A method for replacement of living hard tissue comprising:

providing an implant comprising a ceramic material which contains at least 40% by volume of a diopside composition, a wollastonite composition or a mixture of diopside and wollastonite compositions, and which (i) contains CaO and SiO₂ as essential components, (ii) is substantially free from calcium phosphate and (iii) is capable of forming a compound based in calcium phosphate by contact with an aqueous solution containing phosphorous, said CaO and SiO₂ being present in a weight ratio of CaO to SiO₂ of between 1;

4 and 6;

1; and

inserting said implant into a living body to replace living hard tissue.

2. The process as claimed in claim 1, wherein said ceramic material contains MgO in addition to the essential components of CaO and SiO₂.

3. The process as claimed in claim 2, wherein said ceramic material contains 10 to 88% by weight of CaO, 10 to 80% by weight of SiO₂ and 2 to 35% by weight of MgO.

4. The process as claimed in claim 3, wherein said ceramic material contains 18 to 47% by weight of CaO, 37 to 68% by weight of SiO₂ and 10 to 25% by weight of MgO.

5. The process as claimed in claim 1, wherein said ceramic material contains at least 40% by volume of a diopside composition.

6. The process as claimed in claim 1, wherein said ceramic material contains at least 50% by volume of a diopside composition, a wollastonite composition or a mixture of diopside and wollastonite compositions.

7. The process as claimed in claim 6, wherein said ceramic material contains 70% to 100% by volume of a diopside composition, a wollastonite composition or a mixture of diopside and wollastonite compositions.

8. The process as claimed in claim 1, wherein said implant comprises a substrate having a coat layer of said ceramic material on a surface thereof.

9. The process as claimed in claim 8, wherein said coat layer has a thickness of 1 to 5000 gm.

10. The process as claimed in claim 1, wherein said coat layer has a thickness of 10 to 2000 μ

m.

11. The process as claimed in claim 10, wherein said coat layer has a thickness of 20 to 1000 μ

m.

12. The process as claimed in claim 8, wherein said coat layer has a surface roughness of 1 to 200 μ

m.

13. The process as claimed in claim 12, wherein said coat layer has a surface roughness of 5 to 100 μ

m.

14. The process as claimed in claim 8, wherein said coat layer is porous.

15. The process as claimed in claim 8, wherein said substrate comprises metal, ceramic, glass or plastic.

16. The process as claimed in claim 6, wherein said substrate comprises a metal selected from the group consisting of Ti, W, Ni-Cr alloy, Fe-Cr-Al alloy, Ti-Zr alloy, Fe-Ni-Cr alloy, Mo, Ti-Al-V alloy, Co-Cr-Mo alloy, Ti-Mo alloy, Co-Cr-Ni alloy, stainless steel 304, stainless steel 310 and stainless steel 316.

17. The process as claimed in claim 6, wherein said substrate comprises Ti or an alloy thereof.

18. The process as claimed in claim 6, wherein said substrate comprises a ceramic selected from the group consisting of alumina, zirconia, silicon carbide, tungsten nitride and silicon nitride.

19. The process as claimed in claim 1, wherein said implant is a porous body of said ceramic material having a pore diameter of 5 to 2000 μ

m and a porosity of 10 to 80%.

20. The process as claimed in claim 19, wherein said porous body has a pore diameter of 10 to 1000 μ

m.

21. The process as claimed in claim 19, wherein said porous body has a porosity of 20 to 70%.

22. The process as claimed in claim 21, wherein said porous body has a porosity of 25 to 60%.