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Delivery system for controlled release of bioactive factors

  • US 5,356,630 A
  • Filed: 05/07/1993
  • Issued: 10/18/1994
  • Est. Priority Date: 02/22/1989
  • Status: Expired due to Fees
First Claim
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1. A method of selectively delivering a bioactive substance for inducing formation of cartilage and bone in an animal or wound healing to a specific physical site in an animal comprising implanting in the animal at the selected site a delivery composition comprising a shaped matrix sized and adapted for administration of the bioactive substance to an animal, whereina. the matrix is formed of from about 10 percent to about 90 percent by weight of a surface eroding polyanhydride or polyorthoester polymer;

  • andb. the matrix contains from about 90 percent to about 10 percent by weight of a bioactive substance selected from the group consisting of a mixture of water soluble chondrogenic or osteogenic proteins derived from demineralized bone matrix, TGF-beta, EGF, FGF and PDGF;

    wherein the composition erodes at a controlled rate over a period of time as a result of hydrolysis of the polymer, thereby administering the bioactive substance to the animal in an amount effective to induce formation of cartilage and bone or wound healing, wherein the same amount administered to the animal in the absence of the matrix is not effective to induce formation of cartilage and bone or wound healing.

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