Transdermal drug delivery device

• US 5,356,632 A
• Filed: 09/12/1991
• Issued: 10/18/1994
• Est. Priority Date: 09/12/1991
• Status: Expired due to Term

• Current Assignee: Elan Medical Technologies (E.M.T.) Israel Limited, Elan Medical Technologies Ltd. (Perrigo Company PLC)
• Original Assignee: S.I. Scientific Innovations, Ltd.
• Inventors: Zucker, Shlomo, Gross, Joseph
• Primary Examiner(s): BROUILLETTE, D GABRIELLE
• Application Number:
  US07/759,006
• Time in Patent Office: 1,132 Days
• Field of Search: 424/449, 604/20
• US Class Current: 424/449
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0448 Drug reservoir
• CPC Class Codes: A61N 1/303 Constructional details electrodes for external use A61N1/0428

Abstract

A transdermal drug delivery device includes anode and cathode electrodes supported on a base member in spaced relation to each other to define a gap therebetween, a gel containing a liquid drug to be delivered covering the gap and in contact with both of the electrodes, and a liquid permeable sheet covering the gel containing the liquid to be delivered.

Claims

1. A transdermal drug delivery device for application to a subject'"'"'skin, comprising:

a base member of insulating material;

an anode electrode and a cathode electrode supported on said base member in spaced relation to each other to define a gap therebetween;

means for connecting said electrodes to a voltage source;

and an insulating layer releasably containing a liquid drug to be delivered covering said gap and both of said electrodes such that neither of said electrodes comes into contact with the subject'"'"'s skin when applied thereto.

2. The device according to claim 1, further including a liquid permeable sheet covering said insulating layer releasably containing the liquid to be delivered.

3. The device according to claim 2, wherein said liquid permeable sheet is a porous absorbent sheet of hydrophilic material.

4. The device according to claim 2, wherein said base member includes a backing sheet having an adhesive coating for adhesively applying the device to a patient'"'"'s skin with the liquid permeable sheet in contact with the patient'"'"'s skin.

5. The device according to claim 2, further including a wrist band for applying the device to the wrist of a patient, with the liquid-permeable sheet in contact with the patient'"'"'s skin.

6. The device according to claim 1, wherein said base member further supports a battery having its positive-terminal connected to said anode electrode, and its negative-terminal connected to said cathode electrode for supplying current to said insulating layer via said electrodes.

7. The device according to claim 6, wherein said base member further supports an electrical control means for controlling the current supplied to said insulating layer.

8. The device according to claim 7, wherein said electrical control means comprises a presettable resistor for presetting the magnitude of the current to be supplied to said insulating layer, and an electrical switch for supplying the electrical current to said insulating layer.

9. The device according to claim 7, wherein said electrical control means comprises a preprogrammable microprocessor for pre-programming the magnitude of the current to be supplied to said insulating layer, and the time periods during which the electrical current is to be supplied to the insulating layer.

10. The device according to claim 1, wherein each of said electrodes includes a plurality of branches electrically connected together but physically spaced from each other, the branches of the anode electrode being paired with, but spaced from, the branches of the cathode electrode to form a plurality of gaps, all of which gaps are covered by said insulating layer releasably containing the liquid drug to be delivered.

11. The device according to claim 10, wherein said electrode branches are in the form of parallel strips, the strips of the anode electrode branches alternating with the strips of the cathode electrode branches.

12. The device according to claim 11, wherein said electrodes are arranged in a plurality of groups occupying different areas of said base sheet, enabling the electrodes of each group to be selectively energized at different times to deliver the drug of the insulating layer in the respective area at different times.

13. A transdermal drug delivery device for application to a subject'"'"'s skin, comprising:

a base member of insulating material;

an anode electrode and a cathode electrode supported on said base member in spaced relation to each other to define a gap therebetween;

an insulating layer including a gel containing a liquid drug to be delivered covering said gap and in contact with and covering both of said electrodes;

means for connecting said electrodes to a voltage source;

and a liquid permeable sheet covering said gel containing the liquid to be delivered such that neither of said electrodes comes into contact with the subject'"'"'s skin when applied thereto.

14. The device according to claim 13, wherein said liquid permeable sheet is a porous absorbent sheet of hydrophilic material.

15. The device according to claim 13, wherein said base member further supports a battery having its positive-terminal connected to said anode electrode, and its negative-terminal connected to said cathode electrode for supplying current to said gel in contact with said electrodes.

16. The device according to claim 13, wherein said base member further supports an electrical control mean for controlling the current supplied to said gel.

17. The device according to claim 16, wherein said electrical control means comprises a preprogrammable microprocessor for pre-programming the magnitude of the current to be supplied to said gel, and the time periods during which the electrical current is to be supplied to the gel.

18. The device according to claim 13, wherein each of said electrodes includes a plurality of branches electrically connected together but physically spaced from each other, the branches of the anode electrode being paired with, but spaced from, the branches of the cathode electrode to form a plurality of gaps, all of which gaps are covered by said gel containing the liquid drug to be delivered.

19. The device according to claim 18, wherein said electrode branches are in the form of parallel strips, the strips of the anode electrode branches alternating with the strips of the cathode electrode branches.

20. The device according to claim 19, wherein said electrodes are arranged in a plurality of groups occupying different areas of said base sheet, enabling the electrodes of each group to be selectively energized at different times to deliver the drug of the gel in the respective area at different times.