Method of treatment of inflamed tissues
First Claim
1. A method of concentrating a therapeutic compound in an inflamed dermal region in a subject, comprisingadministering to the subject, by parenteral injection, a composition of liposomes (i) composed of vesicle-forming lipids including an amphipathic vesicle-forming lipid derivatized with a hydrophilic biocompatible polymer selected from the group consisting of a polyethylene glycol having a molecular weight between about 300 and 5,000 daltons, polyglycolic acid (PGA), polylactic acid (PLA), a copolymer of PGA and PLA, and polyvinyl alcohol (ii) having a selected mean particle diameter in the size range between about 0.07-0.20 microns, and (iii) containing in liposome-entrapped form, a therapeutic compound effective against the source of the inflammation, andby said injecting, concentrating the liposomes in the inflamed region, thereby to concentrate liposome-entrapped compound at the site of inflammation.
1 Assignment
0 Petitions
Accused Products
Abstract
A method of and composition for concentrating a therapeutic agent in an inflamed dermal region are disclosed. The composition, which is also used in the method, is a liposomal composition. The liposomes contain the therapeutic agent in entrapped form and are composed of vesicle-forming lipids including a vesicle-forming lipid derivatized with hydrophilic biocompatible polymer. After intravenous administration, the liposomes are taken up by the inflamed region within 24-48 hours, for site-specific release of entrapped compound into the inflamed region.
-
Citations
6 Claims
-
1. A method of concentrating a therapeutic compound in an inflamed dermal region in a subject, comprising
administering to the subject, by parenteral injection, a composition of liposomes (i) composed of vesicle-forming lipids including an amphipathic vesicle-forming lipid derivatized with a hydrophilic biocompatible polymer selected from the group consisting of a polyethylene glycol having a molecular weight between about 300 and 5,000 daltons, polyglycolic acid (PGA), polylactic acid (PLA), a copolymer of PGA and PLA, and polyvinyl alcohol (ii) having a selected mean particle diameter in the size range between about 0.07-0.20 microns, and (iii) containing in liposome-entrapped form, a therapeutic compound effective against the source of the inflammation, and by said injecting, concentrating the liposomes in the inflamed region, thereby to concentrate liposome-entrapped compound at the site of inflammation.
Specification