Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
First Claim
1. A method of separating healing tissues nd maintaining said separation during the healing process after surgery, said method comprising introducing into a surgical site, either during surgery or post-operatively, a water insoluble biocompatible gel comprising a modified hyaluronic acid in which at least about 5% of carboxyl functionalities have been derivatized, and wherein essentially all of the derivatized functionalities are O-acyl or N-acyl ureas, said gel causing said separation of the healing tissues to be established and maintained post-operatively for a period of at least about seven days.
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Abstract
This invention describes a method for preparing water-insoluble biocompatible gels, films and sponges by reacting hyaluronic acid, or a salt thereof, with a carbodiimide in the absence of a nucleophile or a polyanionic polysaccharide. The water-insoluble gels, films and sponges of this invention may be used as surgical aids to prevent adhesions of body tissues and as drug delivery vehicles.
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Citations
6 Claims
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1. A method of separating healing tissues nd maintaining said separation during the healing process after surgery, said method comprising introducing into a surgical site, either during surgery or post-operatively, a water insoluble biocompatible gel comprising a modified hyaluronic acid in which at least about 5% of carboxyl functionalities have been derivatized, and wherein essentially all of the derivatized functionalities are O-acyl or N-acyl ureas, said gel causing said separation of the healing tissues to be established and maintained post-operatively for a period of at least about seven days.
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2. A method of preventing post-operative adhesion between healing tissues during the healing process, said method comprising introducing into a surgical site, either during surgery or post-operatively, a water insoluble biocompatible gel comprising a modified hyaluronic acid in which at least about 5% of or more carboxyl functionalities have been derivatized, and wherein essentially all of the derivatized functionalities are O-acyl or N-acyl ureas, said gel preventing said adhesion of the healing tissues to be established and maintained post-operatively for a period of at least about 7 days.
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3. A method of separating healing tissues and maintaining said separation during the healing process after surgery, said method comprising introducing into a surgical site, either during surgery or post-operatively, a biocompatible film comprising a modified hyaluronic acid in which at least about 5% of carboxyl functionalities have been derivatized, and wherein essentially all of the derivatized functionalities are O-acyl or N-acyl ureas, said film causing said separation of the healing tissues to be established and maintained post-operatively for a period of at least about seven days.
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4. A method of preventing post-operative adhesion between healing tissues during the healing process, said method comprising introducing into a surgical site, either during surgery or post-operatively, a biocompatible film comprising modified hyaluronic acid in which at least about 5% of carboxyl functionalities have been derivatized, and wherein essentially all of the derivatized functionalities are O-acyl or N-acyl ureas, said film preventing said adhesion of the healing tissues to be established and maintained post-operatively for a period of at least about 7 days.
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5. A method of separating healing tissues and maintaining said separation during the healing process after surgery, said method comprising introducing into a surgical site, either during surgery or post-operatively, a biocompatible sponge comprising a modified hyaluronic acid in which at least about 5% of carboxyl functionalities have been derivatized, and wherein essentially all of the derivatized functionalities are O-acyl or N-acyl ureas, said sponge causing said separation of the healing tissues to be established and maintained post-operatively for a period of at least about seven days.
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6. A method of preventing post-operative adhesion between healing tissues during the healing process, said method comprising introducing into a surgical site, either during surgery or post-operatively, a biocompatible sponge comprising a modified hyaluronic acid in which at least about 5% of carboxyl functionalities have been derivatized, and wherein essentially all of the derivatized functionalities are O-acyl or N-acyl ureas, said sponge preventing said adhesion of the healing tissues to be established and maintained post-operatively for a period of at least about 7 days.
Specification