Method of and arrangement for diagnosing brain disease
First Claim
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1. A method of diagnosing a brain condition of a patient, comprising the steps of:
- (a) acquiring electrocardiographic signals from the patient;
(b) mathematically determining a plurality of functions descriptive of the patient from the electroencephalographic signals;
(c) establishing a set of indices for each function, each index having two states, each indicative of the brain condition of the patient;
(d) recognizing the state of each index for each function;
(e) generating an integrated pattern of the states of the indices from a plurality of the functions;
(f) storing a collection of index patterns, each containing a multitude of patterns of the states of indices for a multitude of patients whose brain condition is known; and
(g) matching the generated integrated pattern against the stored collection of index patterns to determine the brain condition of the patient being diagnosed.
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Abstract
Brain disease is non-invasively, accurately diagnosed at an early stage. A plurality of functions descriptive of the patient are mathematically determined. A set of indices for each function is established in advance. Each index has two states indicative of the patient'"'"'s condition. An integrated pattern of the states of the indices from a plurality of the functions is generated and matched against a stored collection of index patterns whose diagnosis is known.
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Citations
16 Claims
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1. A method of diagnosing a brain condition of a patient, comprising the steps of:
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(a) acquiring electrocardiographic signals from the patient; (b) mathematically determining a plurality of functions descriptive of the patient from the electroencephalographic signals; (c) establishing a set of indices for each function, each index having two states, each indicative of the brain condition of the patient; (d) recognizing the state of each index for each function; (e) generating an integrated pattern of the states of the indices from a plurality of the functions; (f) storing a collection of index patterns, each containing a multitude of patterns of the states of indices for a multitude of patients whose brain condition is known; and (g) matching the generated integrated pattern against the stored collection of index patterns to determine the brain condition of the patient being diagnosed. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of diagnosing a brain condition of a patient, comprising the steps
(a) acquiring electrical analog electroencephalographic signals from the patient; -
(b) mathematically determining a plurality of functions descriptive of the sample from the analog signals, including power spectrum, transfer function, impulse response, cross correlation and coherence; (c) establishing a set of indices fof each function, each index having two states, each indicative of the condition of the patient; (d) recognizing the state of each index for each function; (e) generating an integrated pattern of the states of the indices from a plurality of the functions; (f) storing a collection of index patterns, each containing a multitude of patterns of the states of indices for a multitude of patients whose condition is known; (g) matching the generated integrated pattern against the stored collection of index patterns to determine the brain condition of the patient; and (h) said establishing step including; (1) HW--Is the highest peak of the power spectrum in the delta band above a limit as well as too wide? (2) OH--Is the highest peak of the power spectrum in the theta band above a limit? (3) As---Is the main peak of the power spectrum of the alpha wave shifted to the theta band? (4) As+--Is the main peak of the power spectrum of the alpha wave shifted to the beta band? (5) EV--Is the transfer function curve too even in the low frequency range? (6) RC--Is the highest peak of the coherence in the theta band higher than that in the alpha band? (7) RT--Is the highest peak of the transfer function in the theta band higher than that in the alpha band? (8) PA--Does the shape of the phase angle wave resemble the letter "W"? (9) LF--Is there a late fluctuation of the impulse response? (10) L3--Is there a delay of the third peak of the impulse response? (11) F/A--Is the ratio of the occurrence frequency/amplitude of the amplitude histogram above a limit?
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16. An arrangement for diagnosing a brain condition of a patient, comprising:
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(a) means for acquiring electroencephalographic signals from the patient; (b) means for mathematically determining a plurality of functions descriptive of the patient from the electroencephalographic signals; (c) means for establishing a set of indices for each function, each index having two states, each indicative of the brain condition of the patient; (d) means for recognizing the state of each index for each function; (e) means for generating an integrated pattern of the states of the indices from a plurality of the functions; (f) means for storing a collection of index patterns, each containing a multitude of patterns of the states of indices for a multitude of patients whose brain condition is known; and (g) means for matching the generated integrated pattern against the stored collection of index patterns to determin the brain condition of the patient being diagnosed.
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Specification