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PH-triggered osmotic bursting delivery devices

  • US 5,358,502 A
  • Filed: 02/25/1993
  • Issued: 10/25/1994
  • Est. Priority Date: 02/25/1993
  • Status: Expired due to Fees
First Claim
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1. An osmotic bursting device for dispensing a beneficial agent to an aqueous environment comprising:

  • a. a pharmaceutical or veterinary agent;

    b. an osmagent;

    c. a wall surrounding said agent and osmagent, said wall formed at least in part of a semipermeable membrane which is permeable to the aqueous environment and substantially impermeable to the beneficial agent and osmagent; and

    d. pH-sensitive trigger means for triggering the bursting of the device and rapid release of beneficial agent as a bolus, said trigger means attached to said semipermeable membrane and said trigger means activated by a predetermined pH of from 3 to 9 wherein said device includes an aqueous swellable material and wherein said device is a capsule, said capsule formed from capsule parts, said capsule parts bonded together with said pH-sensitive trigger.

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