PH-triggered osmotic bursting delivery devices
First Claim
1. An osmotic bursting device for dispensing a beneficial agent to an aqueous environment comprising:
- a. a pharmaceutical or veterinary agent;
b. an osmagent;
c. a wall surrounding said agent and osmagent, said wall formed at least in part of a semipermeable membrane which is permeable to the aqueous environment and substantially impermeable to the beneficial agent and osmagent; and
d. pH-sensitive trigger means for triggering the bursting of the device and rapid release of beneficial agent as a bolus, said trigger means attached to said semipermeable membrane and said trigger means activated by a predetermined pH of from 3 to 9 wherein said device includes an aqueous swellable material and wherein said device is a capsule, said capsule formed from capsule parts, said capsule parts bonded together with said pH-sensitive trigger.
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Accused Products
Abstract
An osmotic bursting device for dispensing a beneficial agent to an aqueous environment. The device comprises a beneficial agent and osmagent surrounded at least in part by a semipermeable membrane. Alternatively the beneficial agent may also function as the osmagent. The semipermeable membrane is permeable to water and substantially impermeable to the beneficial agent and osmagent. A trigger means is attached to the semipermeable membrane (e.g., joins two capsule halves). The trigger means is activated by a pH of from 3 to 9 and triggers the eventual, but sudden, delivery of the beneficial agent. These devices enable the pH-triggered release of the beneficial agent core as a bolus by osmotic bursting.
42 Citations
14 Claims
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1. An osmotic bursting device for dispensing a beneficial agent to an aqueous environment comprising:
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a. a pharmaceutical or veterinary agent; b. an osmagent; c. a wall surrounding said agent and osmagent, said wall formed at least in part of a semipermeable membrane which is permeable to the aqueous environment and substantially impermeable to the beneficial agent and osmagent; and d. pH-sensitive trigger means for triggering the bursting of the device and rapid release of beneficial agent as a bolus, said trigger means attached to said semipermeable membrane and said trigger means activated by a predetermined pH of from 3 to 9 wherein said device includes an aqueous swellable material and wherein said device is a capsule, said capsule formed from capsule parts, said capsule parts bonded together with said pH-sensitive trigger. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An osmotic bursting device for dispensing a beneficial agent to an aqueous environment comprising:
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a. a pharmaceutical or veterinary osmotic agent; b. a wall surrounding said agent, said wall formed at least in part of a semipermeable membrane which is permeable to the aqueous environment and substantially impermeable to the beneficial agent; and c. pH-sensitive trigger means for triggering the bursting of the device and rapid release of beneficial agent as a bolus, said trigger means attached to said semipermeable membrane and said trigger means activated by a predetermined pH of from 3 to 9 wherein said device includes an aqueous swellable material and wherein said device is a capsule, said capsule formed from capsule parts, said capsule parts bonded together with said pH-sensitive trigger. - View Dependent Claims (12)
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13. An osmotic device for dispensing a beneficial agent to an aqueous environment comprising:
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a. an osmotic beneficial agent; b. a wall surrounding said beneficial agent, said wall formed at least in part of a semipermeable membrane which is permeable to the aqueous environment and substantially impermeable to the beneficial agent; and d. pH-sensitive trigger means for triggering the bursting of the device and rapid release of beneficial agent as a bolus, said trigger means attached to said semipermeable membrane and said trigger means activated by a predetermined pH of from 3 to 9 wherein said device excludes a passageway through which the beneficial agent may pass and wherein said bursting is delayed such that said bursting occurs from one to six hours after said pH-sensitive trigger means is triggered.
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14. An osmotic device for dispensing a beneficial agent to an aqueous environment comprising:
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a. a beneficial agent; b. an osmagent; c. a wall surrounding said beneficial agent and osmagent, said wall formed at least in part of a semipermeable membrane which is permeable to the aqueous environment and substantially impermeable to the beneficial agent and osmagent; and d. pH-sensitive trigger means for triggering the bursting of the device and rapid release of beneficial agent as a bolus, said trigger means attached to said semipermeable membrane and said trigger means activated by a predetermined pH of from 3 to 9 wherein said device excludes a passageway through which the beneficial agent may pass and wherein said bursting is delayed such that said bursting occurs from one to six hours after said pH-sensitive trigger means is triggered.
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Specification