Cardiac pacing responsive to multiple activity types

• US 5,360,436 A
• Filed: 04/03/1992
• Issued: 11/01/1994
• Est. Priority Date: 04/03/1992
• Status: Expired due to Fees

• Current Assignee: Advanced Medical Optics Incorporated (Johnson & Johnson)
• Original Assignee: Intermedics Incorporated
• Inventors: Alt, Eckhard, Mestre, Edgar, Matula, Marcus
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US07/863,093
• Time in Patent Office: 942 Days
• Field of Search: 607/18, 607/19
• US Class Current: 607/18
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration

Abstract

A variable rate implantable pacemaker responsive to patient exercise senses and distinguishes between distinct and different types of physical activity by the patient, and is programmed to respond by generating different response functions to control the pacing rate according to the specific type of physical activity detected. The response functions are algorithms, taken from the behavior of a healthy person with normally functioning cardiovascular system, of heart rates versus an appropriate parameter of a signal produced by a sensor carried by the patient, for the different types of activity requiring different algorithms, in which the parameter value varies in a predetermined way with exercise. The distinction between the different types of physical activity is derived by techniques including calculation of the absolute level of the sensor signal over time, calculation of the standard deviation relative to the mean of the parameter value of the sensor signal over time, performing pattern recognition by spectral analysis of the sensor signal and organizing different physical stress modes by comparing the various templates so observed with templates representing the different types of physical activity of interest, to determine the specific type of activity in which the patient is engaged, for use in controlling pacing rate.

Claims

1. A variable rate cardiac pacemaker adapted and configured to be implanted in a human patient, and adaptive in rate to different types of patient exercise such as walking and bicycling, comprising:

sensor means adapted to respond to physical exercise by the patient for producing an electrical signal representative of the specific type of physical exercise being engaged in by the patient,

pulse generator means for controllably generating pacing pulses in a range of rates adapted to stimulate the patient'"'"'s heart,

memory means for storing different algorithms denoting heart rate as a function of respective ones of the different types of exercise for a healthy person with a normally functioning cardiovascular system, and

control means responsive to signals produced by said sensor means representative of different types of exercise engaged in by the patient for discriminating between specific types of exercise represented by the respective signals produced by said sensor means, including means having access to said different algorithms of said memory means and responsive to the type of exercise determined by the discrimination for selecting the algorithm corresponding to the type of exercise being engaged in by the patient, and including means to control the pacing rate of said pulse generating means according to the selected algorithm.

2. The invention of claim 1, wherein:

said control means includes means for examining the magnitude of the signal produced by the sensor means over time to distinguish different types of physical exercise from one another.

3. The cardiac pacemaker of claim 1, wherein:

said control means includes means for determining standard deviation and mean of the respective signal produced by the sensor means, and for calculating quotient of standard deviation divided by mean to distinguish different types of physical exercise from one another.

4. The cardiac pacemaker of claim 3, wherein:

said means for calculating quotient of the standard deviation divided by the mean of the signal produced by the sensor means comprises timing means for defining prescribed intervals of time over which the calculation is to be performed, and means for performing the calculation over said prescribed intervals of time.

5. The invention of claim 1, wherein:

said control means includes means for comparing the patterns of signals produced by the sensor means over time to distinguish different types of physical exercise from one another.

6. The invention of claim 5, wherein:

the means for comparing the patterns of signals produced by the sensor means over time compares each pattern with those among a library of patterns of exercise representative signals produced by a sensor corresponding to said sensor means, and

said control means further includes means for storing said library of patterns to make them available for comparison with patterns of signals produced by the sensor means.

7. The invention of claim 1, wherein:

said control means includes means for recognizing patterns of signals produced by the sensor means by performing spectral analysis of the signals to distinguish different types of physical exercise from one another.

8. The cardiac pacemaker of claim 1, wherein:

said sensor means is an activity sensor adapted to respond to the patient'"'"'s movements.

9. The cardiac pacemaker of claim 8, wherein:

said activity sensor is an accelerometer for detecting accelerations attributable to physical exercise by the patient.

10. The cardiac pacemaker of claim 9, further including:

a case housing said pulse generator means; and

means for mechanically isolating said accelerometer from said case to render the accelerometer substantially unresponsive to pressure on the case.

11. The cardiac pacemaker of claim 9, further including:

a case housing said pulse generator means; and

a second case housing said accelerometer for implantation in the patient separate from the first named case.

12. The cardiac pacemaker of claim 9, wherein:

said accelerometer comprises integrated electronic circuit means responsive to three-dimensional movement thereof for producing said electrical signal.

13. The cardiac pacemaker of claim 12, wherein:

said integrated electronic circuit means is a silicon based mechanoelectrical converter.

14. The cardiac pacemaker of claim 13, wherein:

said mechanoelectrical converter is selected from the group consisting of piezoelectric, piezocapacitive and piezoresistive converters to convert patient movement to said electrical signal representative thereof.

15. The cardiac pacemaker of claim 8, wherein:

said control means includes means for processing the signal produced by said activity sensor through a low pass filter having a frequency pass band below 10 Hz, to restrict the processed signal to components indicative of exercise by the patient.

16. The cardiac pacemaker of claim 1, wherein:

said sensor means comprises

first and second mercury ball activity sensors each having a multiplicity of contacts in a planar array about which the mercury ball may roll for intermittently establishing electrical connections with the contacts of the respective array upon physical movement of the patient, said sensors fixed with the respective arrays in orthogonal orientation to one another,

said control means comprising means responsive to closures and openings of each array of contacts as the respective mercury ball makes and breaks electrical connections therewith for calculating the quotient of the standard deviation, as variations, divided by the mean value, over time, of electrical closures and openings of each array of contacts resulting from the making and breaking of electrical connections by the respective mercury ball, and comparison means for comparing said quotient to a predetermined value to distinguish the different types of physical exercise by the patient.

17. In combination with an implantable rate responsive pacemaker having a pulse generator adapted to generate pulses for stimulating a patient'"'"'s heart at a variable pacing rate in response to a control signal derived from activity sensing means carried by the patient, the improvement comprising:

control means adapted to respond to each of a plurality of distinct and different activity signals generated by said activity sensing means representing different types of physical activity of the patient, as said control signal, for processing said control signal to detect the specific type of activity being engaged in by the patient and to adjust the pacing rate according to that specific type of activity, said control means including means for storing a plurality of different representations of heart rate as a function of acceleration signals arising from the respective types of physical activity for a healthy person with a normally functioning cardiovascular system, and means for continuously and automatically selecting a particular one of said representations according to the specific type of physical activity detected by said control means from which to adjust the pacing rate.

18. The improvement of claim 17, wherein:

said control means further includes means responsive to said control signal for deriving a pattern therefrom characteristic of the specific type of physical activity represented by said control signal, and means for comparing said pattern to a library of stored patterns characteristic of distinct and different types of physical activity from which to detect the specific type of physical activity represented by said control signal.

19. The improvement of claim 18, wherein:

the pattern deriving means includes means for calculating the standard variation of the control signal relative to the mean of the control signal over time.

20. The improvement of claim 18, wherein:

the pattern deriving means includes means for performing a spectral analysis of the control signal.

21. A method of distinguishing distinct and different types of physical activity, such as walking and bicycling engaged in by a patient, from one another for the purpose of controlling the pacing rate of a variable rate pacemaker carried by the patient according to the specific type of physical activity in which the patient is engaged, which comprises:

detecting one of an extrinsic parameter and an intrinsic parameter having a variable value representing activity of the patient,

generating a control signal indicative of instantaneous value of said parameter,

processing the control signal over time to derive therefrom the nature of the physical activity being engaged in by the patient, and

controlling the pacing rate of the pacemaker according to the distinguished specific type of activity.

22. The method of claim 21, wherein the step of processing the control signal includes:

calculating the mean value of the control signal variances of the control signal, and the quotient of the variances divided by the mean value of the control signal over time to uniquely distinguish the specific type of activity in which the patient is engaged from others of the distinct and different activity types.

23. The method of claim 21, wherein the step of processing the control signal includes:

comparing the characteristic pattern of the control signal against characteristic patterns associated with each of the distinct and different activity types, to substantially uniquely distinguish the specific type of activity in which the patient is engaged from others of the distinct and different activity types.

24. A method for discriminating true and consistent physiological signals such as a patient'"'"'s sinus rhythm having a variable value depending on patient exercise, from inconsistent or noise signals such as intermittent or otherwise faulty sensing, to control the pacing rate of a variable rate pacemaker carried by the patient in response to the variable value of the physiological signals, which comprises the steps of:

sensing a physiological parameter having a variable value representing the extent of exercise engaged in by the patient,

converting the sensed parameter to an output signal indicative of instantaneous value of said parameter and any noise components present thereon,

processing the output signal by calculating variances, as the standard deviation, and the mean value of the output signal, and calculating the standard deviation relative to the mean value of the output signal over time to discriminate the true variations of the value of the physiological parameter from noise components of the output signal, and

controlling the pacing rate of the pacemaker in response to the processed output signal to vary the pacing rate according to true variations of the value of the physiological parameter while suppressing any contribution attributable to noise components, and thereby, according to true patient exercise.

25. Apparatus for discriminating true and consistent physiological signals such as a patient'"'"'s sinus rhythm having a variable value depending on patient exercise, from inconsistent or noise signals such as intermittent or otherwise faulty sensing, to control the pacing rate of a variable rate pacemaker carried by the patient in response to the variable value of the physiological signals, comprising:

sensor means for sensing a physiological parameter having a variable value representing the extent of exercise engaged in by the patient,

converting means responsive to the sensed parameter for converting the sensed parameter to an output signal indicative of instantaneous value of said parameter and any noise components present thereon,

processing means responsive to the output signal for processing the output signal by calculating variances, as the standard deviation, and the mean value of the output signal, and calculating the standard deviation relative to the mean of the output signal over time to discriminate the true variations of the value of the physiological parameter from noise components of the output signal, and

control means for controlling the pacing rate of the pacemaker in response to the processed output signal to vary the pacing rate according to true variations of the value of the physiological parameter while suppressing any contribution attributable to noise components.

26. A cardiac pacemaker adapted to be carried by a patient and to generate an adjustable pacing rate that recognizes the type and tracks the strenuousness of activity of the patient, comprising:

sensor means responsive to activity of the patient for producing an output representative thereof and including, as well, components attributable to sensed sources other than pure activity that tend to obscure the type and strenuousness of the activity;

control means responsive to the sensor means output for developing a control signal representative of patient activity to adjust the pacing rate based on pure activity of the patient, including means for suppressing a contribution to pacing rate of said components attributable to sources other than pure activity according to the standard deviation relative to the mean of the output, and

generator means responsive to said control signal for generating pulses at an adjustable pacing rate having an instantaneous value based on said pure activity of the patient.

27. The cardiac pacemaker of claim 26, wherein:

said control means includes means responsive to the output of said sensor means for calculating the standard deviation and the mean value of said output, and for dividing the standard deviation by the mean value of the sensor means output over time to discriminate the pure activity component thereof from said components attributable to sources other than pure activity.

28. The cardiac pacemaker of claim 27, wherein:

said control means further includes recognition means responsive to calculation of quotient of the standard deviation relative to the mean value of the sensor means output over time for recognition of the type of physical activity being engaged in by the patient, and means responsive to said recognition and coupled to said generator means for adjusting the pacing rate of the pulses generated by said generating means according to the recognized type of physical activity.

29. The cardiac pacemaker of claim 28, wherein:

said sensor means comprises an accelerometer.

30. A method of adjusting the pacing rate of a cardiac pacemaker to be carried by a patient, according to the type and strenuousness of activity of the patient, including the steps of:

sensing physical activity of the patient to produce an output representative of said physical activity, and including in said output, as well, components attributable to sensed sources other than pure physical activity that tend to obscure the type and strenuousness of the physical activity;

generating pulses at an adjustable rate to set the heart rate of the patient, and

adjusting the pacing rate based on the output component attributable to sensed pure activity of the patient and type of such activity to suppress a contribution to pacing rate of said components attributable to sources other than pure physical activity, by calculating the standard deviation and mean value of said output and dividing standard deviation by mean value over time.