Meconium monitoring system

• US 5,361,759 A
• Filed: 07/01/1993
• Issued: 11/08/1994
• Est. Priority Date: 07/04/1990
• Status: Expired due to Fees

• Current Assignee: British Technology Group Ltd.
• Original Assignee: Charing Cross and Westminster Medical School
• Inventors: Smith, Robin W., Randall, Nigel J., Genevier, Eric S. G., Danielian, Peter J., Steer, Philip J.
• Primary Examiner(s): Sykes, Angela D.
• Application Number:
  US08/084,465
• Time in Patent Office: 495 Days
• Field of Search: 128/633.4, 128/664.5, 356/39-41
• US Class Current: 600/342
• CPC Class Codes: A61B 2562/0238 Optical sensor arrangements for performing transmission measurements on body tissue
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/14507 specially adapted for measuring characteristics of body fluids other than blood devices for taking samples of body liquids A61B10/0045
• CPC Class Codes: A61B 5/4362 Assessing foetal parameters

Abstract

A system for in vivo monitoring of the presence and concentration of meconium and/or blood in amniotic fluid during labor by spectral analysis includes a probe for insertion in the uterus, the probe having a flexible body housing an optical cell. The probe has at least one aperture so that amniotic fluid can enter the cell. A fiber optic cable connects the cell to a light source and to a spectral analyzer, and the probe includes structure for shielding the fiber optic cable from any light scattered by the wall of the uterus or fetus.

Claims

1. A non-invasive system for monitoring the content of amniotic fluid during labor comprising:

a) an optical cell supported in a probe which is capable of insertion into the uterus during labor, said cell having a passageway permitting flow of amniotic fluid therethrough,

b) a source of light of suitable spectral bandwidth optically connected to the cell,

c) photodetecting means optically connected to the cell for detecting light reflected from the amniotic fluid, and

d) processing means for determining the presence of meconium and/or blood in the amniotic fluid by analysis of the spectral content of said reflected light,

said cell being oriented in the probe in such a way that amniotic fluid in said passageway is illuminated by said light source while avoiding any light reflected from the wall of the uterus reaching the photodetecting means.

2. A system according to claim 1 in which the light source and the photodetecting means are located remotely from the probe and are connected to the cell by fiber optic cable.

3. A system according to claim 2 in which the fiber optic cable comprises a bundle of fibers, some of said fibers being optically connected with the light source and others with the photodetecting means.

4. A system according to claim 1 in which the photodetecting means includes first and second photodetectors tuned to detect light reflected at first and second wavelengths at which meconium and blood, respectively, strongly absorb light and a third detector tuned to detect light at a third wavelength at which meconium and blood do not absorb light significantly.

5. A system according to claim 4 in which the first wavelength is about 405 to 420 nm, the second wavelength is about 540 nm and the third wavelength is about 700 nm.

6. An intrauterine probe according to claim 1 wherein the probe comprises a flexible elongated body having a proximal and a distal end and an optical cell housed therein at said distal end, the cell being optically connected by fiber optic cable and the cell being located in the housing so that in use amniotic fluid is able to pass through said passageway in the cell.

7. A probe according to claim 6 wherein the cell has an interior surface which is non-reflecting.

8. A probe according to claim 6 in which the fiber optic cable comprises a bundle of fibers, some of the fibers serving to transmit light and others to convey light reflected by the amniotic fluid to the photodetecting means for detection thereat.

9. An intrauterine probe which comprises a flexible body of generally flat form having substantially flat major surfaces, said probe housing an optical cell which includes at least two apertures permitting the entry and exit of amniotic fluid (AF), said cell being connected to a fiber optic cable, for conducting light to said cell and for conducting light reflected from the AF to spectral analysis means, said probe having shielding means to shield the fiber optic cable from any light scattered by the wall of the uterus or the fetus wherein in use one of the major surfaces of the probe contacts the wall of the uterus.

10. A probe according to claim 9 in which the shielding means are generally planar with the major surfaces of the probe.

11. A probe according to claim 9 in which the substantially flat major surfaces of the probe include one or more longitudinal ribs.

12. A probe according to claim 9 in which each aperture opens into a minor surface of the probe transversely of said major surfaces.

13. A probe according to claim 9 wherein said fiber optic cable passes longitudinally through the probe body and has a tip which emerges at said cell at a first end thereof.

14. A probe according to claim 13 wherein said cell has a second end opposite said first end which is shaped such that light striking said second end is not reflected onto the tip of the fiber optic cable.