Method and apparatus for measuring blood iodine concentration

• US 5,361,761 A
• Filed: 06/17/1992
• Issued: 11/08/1994
• Est. Priority Date: 06/17/1992
• Status: Expired due to Fees

• Current Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Original Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Inventors: Fuerst, Thomas P., Van Lysel, Michael S.
• Primary Examiner(s): ZELE, KRISTA MICHELLE
• Application Number:
  US07/900,143
• Time in Patent Office: 874 Days
• Field of Search: 128/653.1, 128/654, 128/632, 128/771, 378/53, 378/54, 250/370.09, 250/370.11
• US Class Current: 600/407
• CPC Class Codes: A61B 6/481 involving the use of contrast agents
• CPC Class Codes: A61B 6/504 for diagnosis of blood vessels, e.g. by angiography

Abstract

A method and apparatus for measuring blood iodine concentration draws a continuous specimen of blood containing iodine from the left ventricle of the heart and exposes that specimen to a source of X-rays. The attentuated level of X-rays passing through the specimen is compared with the unobstructed level of X-rays to determine the concentration of iodine in the blood. The measurement is then corrected to account for the effects of dispersion caused by the travel of the specimen from the heart to the measurement zone.

Claims

1. An apparatus for measuring blood iodine concentration comprising:

withdrawal means for obtaining a specimen of blood containing iodine,

a source of radiation,

conduit means for passing said specimen through said radiation,

means for detecting a specimen level of radiation passing through said specimen,

means for detecting a source level of radiation emitted by said radiation source,

means for comparing said specimen level to said source level and generating a difference signal representing a measurement of the blood iodine concentration, and

means for correcting said difference signal for effects of dispersion within said withdrawal means.

2. The apparatus defined in claim 1 wherein said withdrawal means comprises a withdrawal pump and catheter connected to the left ventricle of the heart.

3. The apparatus defined in claim 1 wherein said means for detecting the level of radiation passing through said specimen comprises a first photodiode exposed to said radiation, with said conduit means passing said specimen between said radiation source and said first photodiode.

4. The apparatus defined in claim 3 wherein said means for detecting the level of radiation emitted by said radiation source comprises a second photodiode disposed substantially adjacent said first photodiode and exposed to said radiation.

5. The apparatus defined in claim 4 wherein each of said first and second photodiodes generate a signal in response to the detection of radiation and said means for comparing further comprises signal processing circuitry connected to said first and second photodiodes with said circuitry generating said difference signal generated by said first and second photodiodes.

6. The apparatus defined in claim 1 wherein said source of radiation comprises means for generating X-rays.

7. An apparatus for measuring the blood iodine concentration of a blood specimen drawn from the left ventricle of the heart, said apparatus comprising:

a withdrawal means including a pump and catheter connected to the left ventricle of the heart to obtain a specimen of blood containing iodine,

an X-ray source to provide a beam of X-rays,

conduit means for passing said specimen through said beam of X-rays,

a first photodiode disposed in the beam of said X-rays and with said conduit means passing said specimen between said X-ray source and said first photodiode so that said first photodiode detects a specimen level of X-ray radiation,

a second photodiode disposed substantially adjacent said first photodiode and in the beam of said X-rays so that said second photodiode detects a source level of X-ray radiation, with said source level being higher than said specimen level,

means for comparing said specimen level to said source level and generating a difference signal representing a measurement of blood iodine concentration and

means for correcting said difference signal for the effects of dispersion within said withdrawal means.

8. The apparatus defined in claim 7 further comprising an operational amplifier connected to said first and second photodiodes whereby an output signal of said operational amplifier is proportional to the difference signal generated by said means for comparing.

9. A method of measuring blood iodine concentration, as a function of time, following the injection of an iodinated contrast agent into the vascular system comprising the steps of:

withdrawing a specimen of blood at a withdrawal site, through a withdrawal system for an extended period of time, during the period of time that iodinated blood is flowing past the withdrawal site,

exposing said specimen to a source of radiation,

detecting a specimen level of radiation passing through said specimen,

detecting a source reference level of radiation,

measuring the blood iodine concentration by logarithmically subtracting said specimen level from said reference level to obtain a difference signal,

correcting said difference signal for the effects of dispersion within said withdrawal system.

10. The method of measuring blood iodine concentration defined in claim 9 wherein said step of exposing said specimen to a source of radiation comprises exposing said specimen to a source of X-rays.

11. The method of measuring blood iodine concentration defined in claim 9 wherein the specimen withdrawing step comprises drawing blood from the left ventricle of the heart with a withdrawal pump connected to a catheter inserted into the left ventricle.

12. The method of measuring blood iodine concentration defined in claim 9 wherein the exposing of the specimen and detecting of the specimen level steps comprise passing said specimen between an X-ray source and a first photodiode.

13. The method of measuring blood iodine concentration defined in claim 12 wherein said detecting the reference level step comprises exposing a second photodiode to said X-ray source.

14. The method of measuring blood iodine concentration defined in claim 13 wherein said measuring step comprises transmitting signals generated by said first and second photodiodes to an operational amplifier.