Portable pulmonary function testing device and method

• US 5,361,771 A
• Filed: 03/05/1993
• Issued: 11/08/1994
• Est. Priority Date: 03/05/1993
• Status: Expired due to Fees

• Current Assignee: Western Research Corporation
• Original Assignee: Western Research Corporation
• Inventors: Craine, Brian L., Craine, Eric R.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): GREEN, BRIAN
• Application Number:
  US08/027,048
• Time in Patent Office: 613 Days
• Field of Search: 128/716, 128/719, 128/725, 128/730, 73/23.3
• US Class Current: 600/532
• CPC Class Codes: A61B 5/0813 Measurement of pulmonary parameters by tracers, e.g. radioactive tracers

Abstract

Early detection of lung dysfunction, which in HIV positive patients usually indicates PCP pneumonia infection, is accomplished by a CO fractional uptake test which includes supplying air containing 0.1% CO into a gas reservoir or regulator from which it is drawn through a non-rebreather valve into a mouthpiece and inhaled into the lungs of a patient. Exhaled air is directed by the non-rebreather valve into a chamber coupled to a gas inlet of an infrared CO analyzer. An end tidal volume of gas last exhaled by the patient is drawn through the CO analyzer which measures the concentration of CO therein. The concentration of CO in the air from the gas reservoir also is measured. The fractional uptake of CO is computed as a function of the patient'"'"'s breathing rate and the minute volume and compared with a stored baseline value for the patient to determine the presence of or extent of lung dysfunction.

Claims

1. A method of measuring lung function, comprising the steps of:

(a) supplying air containing a first concentration of CO from a gas source into a tube;

(b) opening a first path in a first valve device to allow the air supplied to the tube to be inhaled by a patient through the first valve device and a mouthpiece;

(c) closing the first path to allow air exhaled by the patient to flow through a second path in the first valve device into a gas containing volume;

(d) measuring the CO concentration of air supplied by the gas source by passing some of the supplied air into a CO analyzer and operating the CO analyzer to produce a first signal representing the concentration of CO in the supplied air and converting the first signal to a first number representing the concentration of CO in the supplied air;

(e) measuring the CO concentration of air exhaled by the patient by passing some of the exhaled air from the gas containing volume into the CO analyzer to produce a second signal representing the concentration of CO in the exhaled air and converting the second signal to a second number representing the concentration of CO in the exhaled air;

(f) computing a fractional uptake of CO from the first and second numbers; and

(g) comparing the fractional uptake with a previously stored baseline value.

2. The method of claim 1 including, before step (f), measuring the rate of flow of air exhaled by the patient, wherein the computing of step (f) includes using information based on the measured rate of flow.

3. The method of claim 2 wherein the opening of the first path in step (b) is in response to inhaling by the patient.

4. The method of claim 3 where the closing of the first path in step (c) is in response to exhaling by the patient.

5. The method of claim 4 including repeating steps (a), (b), (c), (e), (f), and (g) for other inhaling and other exhaling by the patient.

6. The method of claim 5 wherein the passing of exhaled air from the gas containing volume includes passing an end tidal volume of air last exhaled by the patient from the gas containing volume into the CO analyzer by turning on a pump coupled to the CO analyzer while the second path is closed.

7. The method of claim 2 including diagnosing the patient as likely to be infected with PCP pneumonia if the present fractional uptake is less than the stored baseline value by a predetermined amount.

8. The method of claim 2 wherein the CO concentration of air supplied by the gas source is approximately 0.1%.

9. The method of claim 2 wherein step (a) includes supplying the air from a gas source through a regulator actuated in response to suction produced at the mouthpiece by inhaling by the patient.

10. The method of claim 2 wherein steps (f) and (g) are performed by a computer, step (f) including computing the fractional uptake of carbon monoxide according to the expression ##EQU4## where F_I is the percentage concentration of CO in the gas supplied by the gas source and F_A is the percentage of CO in the end tidal volume of gas exhaled.

11. An apparatus for measuring lung function, comprising in combination:

(a) a gas source for supplying air containing a particular concentration of CO gas;

(b) a mouthpiece;

(c) a chamber for temporarily storing exhaled air;

(d) a non-rebreather valve device coupled to the gas source, the chamber, and the mouthpiece and including a first valve path to selectively allow air from the gas source to be inhaled through the mouthpiece by a patient and preventing air exhaled by the patient from returning to the gas source, the non-rebreather valve device also including a second valve path to selectively allow air exhaled by the patient to pass into the chamber;

(e) a CO analyzer;

(f) means for passing air from the gas source into the CO analyzer to cause the CO analyzer to produce a first signal representing the concentration of CO in air supplied by the gas source;

(g) means for passing some of the exhaled air in the chamber into the CO analyzer, causing the CO analyzer to produce a second signal representing the concentration of CO in the exhaled air;

(h) an analog-to-digital converter coupled to the CO analyzer a operating to convert the first and second signals into first and second digital numbers representing the CO concentrations in the air supplied by the gas source and the air exhaled by the patient, respectively;

(i) means for computing a fractional uptake of CO from the first and second digital number; and

(j) means for comparing the fractional uptake with a stored baseline value.

12. The apparatus of claim 11 including means for measuring a rate of flow of air exhaled by the patient and means responsive thereto for computing a minute volume for the patient.

13. The apparatus of claim 12 wherein the chamber has a volume at least equal to an end tidal volume.

14. The apparatus of claim 13 wherein the particular concentration of CO from the gas source is approximately 0.1%.

15. The apparatus of claim 14 including a pump coupled to a gas outlet of the CO analyzer, and means for turning on the pump in response to suction produced at the mouthpiece by the patient to produce a negative pressure at the gas outlet of the CO analyzer to draw the end tidal volume of exhaled gas in a portion of tube through the CO analyzer.

16. The apparatus of claim 15 wherein the gas source includes a gas bottle and a regulator connected to the gas bottle and actuated by suction produced at the mouthpiece by the patient.

17. The apparatus of claim 15 wherein the computing means is included in a host computer which computes the fractional uptake of carbon monoxide according to the equation ##EQU5## where F_I is the CO percentage concentration of gas to be inhaled from the gas source and F_A is the CO percentage concentration of an end tidal volume of gas exhaled.

18. An apparatus for measuring lung function, comprising in combination:

(a) a gas source of air containing a particular concentration of CO gas;

(b) a mouthpiece;

(c) a chamber for temporarily storing exhaled air;

(d) a non-rebreather valve device coupled to the gas source, the chamber, and the mouthpiece and including a first valve path to selectively allow air from the gas source to be inhaled through the mouthpiece by a patient and prevent air exhaled by the patient from returning to the gas source, the non-rebreather valve device also including a second valve path to selectively allow air exhaled by the patient to pass into the chamber;

(e) a CO analyzer;

(f) a first conduit coupling the gas source and the CO analyzer to pass air from the gas source into the CO analyzer, the CO analyzer producing a first signal representing the concentration of CO in air from the gas source;

(g) a second conduit coupling the chamber and the CO analyzer to pass some of the exhaled air in the chamber into the CO analyzer, the CO analyzer producing a second signal representing the concentration of CO in the exhaled air;

(h) an analog-to-digital converter coupled to the CO analyzer a operating to convert the first and second signals into first and second digital numbers representing the CO concentrations in the air supplied by the gas source and the air exhaled by the patient, respectively; and

(i) a computing device coupled to the analog-to-digital converter and adapted to compute a fractional uptake of CO from the first and second digital numbers and compare the fractional uptake with a stored baseline value.

19. The apparatus of claim 18 including a pneumotachometer device coupled to the chamber and the computing device, the computing device being adapted to compute a minute volume for the patient.

20. The apparatus of claim 19 wherein the chamber has a volume at least equal to an end tidal volume.

21. The apparatus of claim 18 including a pump coupled to a gas outlet of the CO analyzer and to the computing device, the computing device being adapted to turn on the pump in response to suction produced at the mouthpiece by the patient to produce a negative pressure at the gas outlet of the CO analyzer to draw the end tidal volume of exhaled gas in a portion of tube through the CO analyzer.

22. The apparatus of claim 21 wherein the gas source includes a gas bottle and a regulator connected to the gas bottle and actuated by suction produced at the mouthpiece by the patient.

23. The apparatus of claim 21 wherein the computing device is included in a host computer which computes the fractional uptake of carbon monoxide according to the equation ##EQU6## where F_I is the CO percentage concentration of gas to be inhaled from the gas source and F_A is the CO percentage concentration of an end tidal volume of gas exhaled.