Basal view mapping of brain activity

• US 5,361,773 A
• Filed: 12/04/1992
• Issued: 11/08/1994
• Est. Priority Date: 12/04/1992
• Status: Expired due to Fees

• Current Assignee: BETH Israel Medical Center (Mount Sinai Beth Israel)
• Original Assignee: Beth Israel Hospital
• Inventors: Ives, John R.
• Primary Examiner(s): Sykes, Angela D.
• Application Number:
  US07/985,284
• Time in Patent Office: 704 Days
• Field of Search: 128/731-732
• US Class Current: 600/544
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy

Abstract

A topographic map and method of mapping brain electrical activity including a first set of points representative of electrical activity occurring in a mesial temporal region of a left brain hemisphere and a second set of points representative of electrical activity occurring in a mesial temporal region of a right brain hemisphere are displayed adjacent and a third set of points representative of electrical activity occurring in a mid-line region of a left brain hemisphere and a fourth set of points representative of electrical activity occurring in a mid-line region of a right brain hemisphere are displayed remote. The respective locations of the first and third sets of points are displayed substantially as a mirror image of the respective locations of the second and fourth sets of points.

Claims

1. A graphic display of electrical activity of a brain comprising a first set of points representative of electrical activity occurring in a temporal region of a left brain hemisphere and a second set of points representative of electrical activity occurring in a temporal region of a right brain hemisphere displayed adjacent to one another and a third set of points representative of electrical activity occurring in a mid-line region of a left brain hemisphere and a fourth set of points representative of electrical activity occurring in a mid-line region of a right brain hemisphere displayed remote from one another wherein respective locations of the first and third set of points are displayed substantially as a mirror image of respective locations of the second and fourth sets of points;

and

a display for displaying the first, second, third, and fourth sets of points.

2. The graphic display of claim 1, wherein the first set of points and the second set of points are respectively derived from electrical activity sensed by at least one sphenoidal electrode disposed proximate a mesial temporal lobe.

3. The graphic display of claim 2, wherein the third set of points and the fourth set of points are derived from electrical activity sensed by a set of electrodes located according to an International 10-20 Electrode Placement System.

4. The graphic display of claim 3, further comprising a grid having uniformly spaced locations and wherein points in the first, second, third, and fourth sets of points are displayed at the uniformly spaced locations.

5. The graphic display of claim 3, wherein the first, second, third, and fourth sets of points are additionally displayed three dimensionally such that a value of an electrical discharge represented by a point determines a displacement from a plane of the display representing a locus of points having a reference signal level.

6. The graphic display system of claim 3, further comprising contour lines coupling points from the first, second, third, and fourth sets of points having substantially similar values.

7. The graphic display of claim 3, further comprising contours including respective shades of gray coupling points from the first, second, third, and fourth sets of points having respective predetermined ranges of values.

8. The graphic display of claim 3, further comprising contours including respective colors coupling points from the first, second, third, and fourth sets of points having respective predetermined ranges of values.

9. The graphic display of claim 3, wherein values of points in the first, second, third, and fourth sets of points are normalized with respect to a reference value.

10. The graphic display of claim 9, wherein the reference value is a length of the map from a first set of mid-line points to a second set of mid-line points.

11. A topographic map of electrical discharges occurring in a brain, comprising:

a first set of points representative of electrical discharges occurring in a mesial temporal region of a left brain hemisphere and second set of points representative of electrical discharges occurring in a mesial temporal region of a right brain hemisphere being located adjacent on the topographic map; and

a third set of points representative of electrical discharges occurring in a mid-line region of a left brain hemisphere and a fourth set of points representative of electrical discharges occurring in a mid-line region of a right brain hemisphere being located adjacent the first and second set of points, respectively; and

a display for displaying the first, second, third, and fourth sets of points.

12. The topographic map of claim 11, wherein the first set of points and the second set of points are respectively derived from electrical discharges sensed by at least one sphenoidal electrode disposed proximate a mesial temporal lobe.

13. The topographic map of claim 12, wherein the third set of points and the fourth set of points are derived from electrical discharges sensed by a set of electrodes located according to an International 10-20 Electrode Placement System.

14. The topographic map of claim 12, further comprising a grid having uniformly spaced locations and wherein points in the first, second, third, and fourth sets of points are disposed at the uniformly spaced locations.

15. The topographic map of claim 12, wherein the first, second, third, and fourth sets of points are additionally located three dimensionally such that a value of an electrical discharge represented by a point determines a displacement from a plane of the map representing a locus of points having a reference signal level.

16. The topographic map of claim 12, further comprising contour lines coupling points from the first, second, third, and fourth sets of points having substantially similar values.

17. The topographic map of claim 12, further comprising contours including respective shades of gray coupling points from the first, second, third, and fourth sets of points having respective predetermined ranges of values.

18. The topographic map of claim 12, further comprising contours including respective colors coupling points from the first, second, third, and fourth sets of points having respective predetermined ranges of values.

19. The topographic map of claim 12, wherein values of points in the first, second, third, and fourth sets of points are normalized with respect to a reference value.

20. The topographic map of claim 19, wherein the reference value is a length of the map from a first set of mid-line points to a second set of mid-line points.

21. A method for mapping electrical activity occurring in a brain, comprising the steps of:

locating a first set of points representative of electrical activity occurring in a mesial temporal region of a left brain hemisphere and a second set of points representative of electrical activity occurring in a mesial temporal region of a right brain hemisphere adjacent on a topographic map; and

locating a third set of points representative of electrical activity occurring in a mid-line region of a left brain hemisphere and a fourth set of points representative of electrical activity occurring in a right brain hemisphere respectively adjacent the first and second set of points on the topographic map.

22. The method of claim 21, further comprising the steps of:

sensing electrical activity using at least one sphenoidal electrode disposed proximate a left mesial temporal lobe and at least one sphenoidal electrode disposed proximate a right mesial temporal lobe; and

respectively deriving the first and second sets of points from the sensed electrical activity.

23. The method of claim 22, further comprising the steps of:

sensing electrical activity using a first set of electrodes located according to an International 10-20 Electrode Placement System; and

deriving the third and fourth sets of points from the electrical activity sensed by the first set of electrodes.

24. The method of claim 23, further comprising the step of averaging signals corresponding to a plurality of waveforms within an ictal event, each waveform representing an individual discharge sensed by the at least one sphenoidal electrode and the first set of electrodes and deriving the first, second, third, and fourth sets of points from the averaged signals.

25. The method of claim 24, further comprising the step of averaging signals corresponding to a plurality of waveforms within an interictal event, each waveform representing an individual discharge sensed by the at least one sphenoidal electrode and the first set of electrodes and deriving the first, second, third, and fourth sets of points from the average of the signals corresponding to the plurality of ictal events and the signals corresponding to the plurality of interictal events.

26. The method of claim 23, further comprising the step of locating the first, second, third, and fourth sets of points three dimensionally on the map such that a value of electrical activity represented by a point determines a displacement from a plane of the map representing a locus of points having a reference signal level.