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Oligonucleotide polymeric support system with an oxidation cleavable link

  • US 5,362,866 A
  • Filed: 03/17/1992
  • Issued: 11/08/1994
  • Est. Priority Date: 09/02/1983
  • Status: Expired due to Term
First Claim
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1. A process comprising the steps of:

  • (a) providing a compound consisting essentially of a polymeric support and a primer, said compound having the structure;

    ##STR1## wherein S is a solid support, is a spacer of 1 to 50 atoms which is not cleaved under acidic or basic deprotecting conditions of oligonucleotide synthesis and is attached to said polymeric support, R8 is a protecting group on an oxidizable substituent and R7 is a protecting group for --OH;

    (b) synthesizing an oligonucleotide having base-labile protective groups on the nucleotides onto the O of OR7 ; and

    (c) removing the protecting groups with a base.

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