Method of detecting anomalies of the skin, more particularly melanomae, and apparatus for carrying out the method

• US 5,363,854 A
• Filed: 08/14/1991
• Issued: 11/15/1994
• Est. Priority Date: 08/24/1990
• Status: Expired due to Fees

• Current Assignee: US Philips Corporation (Koninklijke Philips N.V.)
• Original Assignee: US Philips Corporation (Koninklijke Philips N.V.)
• Inventors: Gunzel, Erhard P. H., Martens, Gerhard
• Primary Examiner(s): Sykes, Angela D.
• Application Number:
  US07/745,023
• Time in Patent Office: 1,189 Days
• Field of Search: 128/664, 128/665, 128/633, 356/317, 356/318, 356/390, 356/417-420, 250/461.1, 250/461.2, 250/459.1
• US Class Current: 600/477
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/444 Evaluating skin marks, e.g. mole, nevi, tumour, scar
• CPC Class Codes: A61B 5/7207 of noise induced by motion artifacts

Abstract

An apparatus for detecting anomalies of the skin, more particularly melanomae, includes a light source for illuminating a two-dimensionally extending examination region of the skin, successively, with ultraviolet light range and with visible light. A camera records a fluorescence picture of the examination region having signal values F(x,y) at its picture points x,y in response to the illumination with ultraviolet light and a reference picture having signal values R(x,y) at its picture points x,y in response to the illumination with visible light. A memory stores the signal values of at least one of the fluorescence picture and said reference picture, and a processor responsive to the memory produces an output picture having respective signal values A(x,y) at its picture points x,y which are formed from respective quotients F(x,y)/R(x,y) of the signal values of the fluorescence and reference pictures at the same picture points. Various filters are provided positioned or positionable between the light source and the examination region or in front of the camera.

Claims

1. An apparatus for detecting anomalies of the skin comprising light illumination means for illuminating a two-dimensionally extending examination region of said skin, via a beam between said illuminating means and said examination region with light in an ultraviolet wavelength range during a first time interval and with light in a visible wavelength range during a second time interval different from said first time interval;

a camera means for recording a fluorescence picture of fluorescent light from the examination region during the first time interval produced by said skin in response to said light in the ultraviolet wavelength range, said fluorescence picture having signal values F(x,y) at its picture points x,y and for recording a reference picture of the examination region during the second time interval in response to said light in the visible wavelength range, said reference picture having signal values R(x,y) at its picture points x,y during the second time interval;

memory means for storing the signal values of at least one of the fluorescence picture and said reference picture; and

processing means responsive to said memory means for producing an output picture having respective signal values A(x,y) at its picture points x,y which are formed from respective quotients F(x,y)/R(x,y) of the signal values of the fluorescence and reference pictures at the same picture points.

2. An apparatus as claimed in claim 1, wherein said light illumination means comprises at least one light source means for emitting light simultaneously in said ultraviolet and visible wavelength ranges via said beam path between said light illumination means and said examination region;

a first filter selectively positionable in said beam path for transmitting light in said ultraviolet wavelength range while suppressing transmission of light in said visible wavelength range; and

a second filter selectively positionable in said beam path between said light illumination means and said examination region for transmitting light in said visible wavelength range while suppressing transmission of light in said ultraviolet wavelength range.

3. An apparatus as claimed in claim 2 including a frosted pane present in said beam path.

4. An apparatus as claimed in claim 3 including a filter arranged before the camera means for suppressing light from the ultraviolet wavelength range while transmitting light from a wavelength range of the fluorescent light.

5. An apparatus as claimed in claim 4 including a filter arranged before the camera means for suppressing transmission of light from the ultraviolet wavelength range while transmitting light from the visible wavelength range.

6. An apparatus as claimed in claim 5 including polarization filters adapted for selective placement into a beam path between the camera means and the light illumination means, which polarization filters are shaped and arranged for suppressing any directed reflection in the reference picture produced by the camera.

7. An apparatus as claimed in claim 6 wherein the visible wavelength range is an isobestic range.

8. An apparatus as claimed in claim 5 wherein the visible wavelength range is an isobestic range.

9. An apparatus as claimed in claim 2 including a third filter arranged before the camera means for suppressing transmission of light from the ultraviolet wavelength range while transmitting light from the visible wavelength range.

10. An apparatus as claimed in claim 1 including a frosted pane present in said beam path.

11. An apparatus as claimed in claim 10 including a filter arranged before the camera means for suppressing transmission of light from the ultraviolet wavelength range while transmitting light from the visible wavelength range.

12. An apparatus as claimed in claim 10 wherein the visible wavelength range is an isobestic range.

13. An apparatus as claimed in claim 1 including a filter, arranged before the camera means, for suppressing light from the ultraviolet wavelength range while transmitting light from a wavelength range of the fluorescent light.

14. An apparatus as claimed in claim 13 wherein the visible wavelength range is an isobestic range.

15. An apparatus as claimed in claim 1 including a filter, arranged before the camera means, for suppressing transmission of light from the ultraviolet wavelength range while transmitting light from the visible wavelength range.

16. An apparatus as claimed in claim 15 including polarization filters adapted for selective placement into a beam path between the camera means and the light illumination means, which polarization filters are shaped and arranged for suppressing any directed reflection in the reference picture produced by the camera.

17. An apparatus as claimed in claim 1 including polarization filters adapted for selective placement into a beam path between the camera means and the light illumination means, which polarization filters are shaped and arranged for suppressing any directed reflection in the reference picture produced by the camera.

18. An apparatus as claimed in claim 17 wherein the visible wavelength range is an isobestic range.

19. An apparatus as claimed in claim 1 wherein the visible wavelength range is an isobestic range.

21. A method as claimed in claim 1, wherein said illuminating with light in said ultraviolet wavelength range and said illuminating with light in said visible wavelength range each comprises emitting light from a source simultaneously in said ultraviolet and visible wavelength ranges via a beam path between said source and said examination region, said illuminating with light in said ultraviolet wavelength range further comprising imposing a first filter in said beam path between said source and said examination region for transmitting light in said ultraviolet wavelength range while suppressing transmission of light in said visible wavelength range and said illuminating with light of said second wavelength range further comprising imposing a second filter in said beam path between said source and said examination region for transmitting light in said visible wavelength range while suppressing transmission of light in said ultraviolet wavelength range.

20. A method of detecting anomalies of the skin comprising illuminating a two-dimensionally extending examination region of said skin with light in an ultraviolet wavelength range during a first time interval;

recording a fluorescence picture of fluorescent light from the examination region during said first time interval produced by said skin in response to said light in an ultraviolet light range, said fluorescence picture having signal values F(x,y) at its picture points x,y;

illuminating the examination region with light in a visible wavelength range during a second time interval different from said first time interval;

recording a reference picture during the second time interval in response to said light in the visible wavelength range, said reference picture having signal values R(x,y) at its picture points x,y;

storing the signal values of at least one of the recorded fluorescence and reference pictures; and

producing an output picture having signal values A(x,y) at its picture points x,y which is formed from respective quotients F(x,y)/R(x,y) of the signal values of the fluorescence and reference pictures at the same picture points.