Microneedle for injection of ocular blood vessels
First Claim
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1. A device for microvascular injection of a solution into a small blood vessel in vivo, comprising in combination:
- a) a reservoir comprising a syringe and a hypodermic needle;
b) a flexible tubing having a continuously tapered bore and a first end and a second end, the first end of the flexible tubing being operatively linked to the hypodermic needle, wherein the bore of the flexible tubing is at least about 300 microns in inner diameter at the first end and is sufficient to fit over the hypodermic needle; and
c) a microneedle having a length of about 1 to about 5 millimeters and an outer diameter of about 20 microns to about 100 microns, and a first end and a second end, the first end of the microneedle being operatively linked to the second end of the flexible tubing, wherein the bore of the flexible tubing is from about 20 microns to about 100 microns in width at said second end and is sufficient to fit over the first end of the microneedle, wherein the microneedle is further characterized by having sides that are not tapered.
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Abstract
This invention is a device for microvascular injection and a method for treating glaucoma using the device. The device comprises a reservoir attached to a blunted needle connected to a flexible tapered tubing, at the end of which is positioned a microneedle or micropipette for inserting into small blood vessels. The invention also provides a method for treating glaucoma and other diseases wherein microinjection of disease-ameliorating drugs into small blood vessels and their capillary beds would be therapeutically effective.
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Citations
11 Claims
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1. A device for microvascular injection of a solution into a small blood vessel in vivo, comprising in combination:
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a) a reservoir comprising a syringe and a hypodermic needle; b) a flexible tubing having a continuously tapered bore and a first end and a second end, the first end of the flexible tubing being operatively linked to the hypodermic needle, wherein the bore of the flexible tubing is at least about 300 microns in inner diameter at the first end and is sufficient to fit over the hypodermic needle; and c) a microneedle having a length of about 1 to about 5 millimeters and an outer diameter of about 20 microns to about 100 microns, and a first end and a second end, the first end of the microneedle being operatively linked to the second end of the flexible tubing, wherein the bore of the flexible tubing is from about 20 microns to about 100 microns in width at said second end and is sufficient to fit over the first end of the microneedle, wherein the microneedle is further characterized by having sides that are not tapered. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification