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Method of administration of insulin

  • US 5,364,838 A
  • Filed: 01/29/1993
  • Issued: 11/15/1994
  • Est. Priority Date: 01/29/1993
  • Status: Expired due to Term
First Claim
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1. A method of intrapulmonary administration of insulin, comprising:

  • measuring the inspiratory flow of a patient and calculating a threshold level in an inhalation cycle at which release of drug is to take place, the threshold level being determined in a manner so as to maximize the repeatability of the amount of insulin delivered to the patient on releasing insulin;

    releasing a metered dose of aerosolized insulin from a pressurized canister containing insulin in combination with a low boiling point propellant, the releasing being carried out upon reaching the threshold level generated by the patient inhaling;

    inhaling the metered dose of aerosolized insulin into the lungs of a patient; and

    monitoring serum glucose levels within the patient;

    wherein the measuring, releasing, inhaling and monitoring steps are continuously repeated in a manner so as to maintain a desired serum glucose level in the patient.

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