Low cost means for increasing measurement sensitivity in LED/IRED near-infrared instruments

• US 5,365,066 A
• Filed: 11/23/1992
• Issued: 11/15/1994
• Est. Priority Date: 01/19/1989
• Status: Expired due to Fees

• Current Assignee: Futrex, Inc.
• Original Assignee: Futrex, Inc.
• Inventors: Krueger, Don E. Jr., Rosenthal, Robert D.
• Primary Examiner(s): Dzierzynski, Paul M.
• Assistant Examiner(s): HANIG, RICHARD E
• Application Number:
  US07/980,272
• Time in Patent Office: 722 Days
• Field of Search: 250/341, 250/252.1, 250/339, 250/343, 250/346, 356/39, 128/633
• US Class Current: 250/341.2
• CPC Class Codes: A61B 5/02433 for infrared radiation
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: G01N 21/314 with comparison of measurements at specific and non-specific wavelengths dual wavelength spectrometry G01J3/427
• CPC Class Codes: G01N 21/359 using near infrared light

Abstract

A low cost means for increasing measurement sensitivity in LED near-infrared instruments is disclosed which utilizes a current modification means for modifying the driving current supplied to each IRED as a function of the opacity of the particular sample being measured. The current modification means is part of the processing means and comprises means for measuring a signal level for each IRED at an analog-to-digital converter. Based upon the signal level detected for each IRED, the current modification means modifies the current to each IRED to a value that is as high as possible without saturating the analog-to-digital converter. Thus, by modifying the driving current of each IRED to such a maximal value, the analytical instrument of the present invention provides high resolution without the use of expensive electronic circuitry. Also provided is a system for generating and storing an optical signature of a particular user, thus further insuring the accuracy of measurements taken by the instrument.

Claims

1. A near-infrared quantitative analysis instrument for non-invasive measurement of a constituent of a product, said analysis instrument comprising:

(a) introducing means including a near-infrared energy source including infrared emitting diodes for introducing near-infrared energy into a product;

(b) detector circuit means for detecting near-infrared energy emerging from said product, said detecting means producing a signal indicative of said energy emerging from said product;

(c) means for supplying current to each of said infrared emitting diodes in said introducing means;

(d) current modification means for modifying the current supplied to each infrared emitting diode in response to said signal from said detector circuit means; and

(e) processing means for calculating the electrical signal from said detector circuit means into a signal indicative of the quantity of said constituent present in said product.

2. The near-infrared analysis instrument as set forth in claim 1, wherein said detector circuit means comprises an analog-to-digital converter which generates a signal representative of the energy emerging from said product.

3. The near-infrared analysis instrument as set forth in claim 2, wherein said detector circuit means comprises a programmable gain amplifier.

4. The near-infrared analysis instrument as set forth in claim 2, wherein said analog-to-digital converter is a 12-bit analog-to-digital converter.

5. The near-infrared analysis instrument as set forth in claim 2, wherein said current modification means modifies the current to an IRED in response to the signal from said analog-to-digital converter.

6. The near-infrared analysis instrument as set forth in claim 1, wherein said current modification means comprises an infrared emitting diode current control circuit for modifying the current to an infrared emitting diode.

7. The near-infrared analysis instrument as set forth in claim 1, wherein said processing means comprises means for calculating the quantity of a blood analyte present in the blood of a subject.

8. The near-infrared analysis instrument as set forth in claim 1, wherein said processing means comprises means for calculating the amount of protein present in a wheat sample.

9. The near-infrared analysis instrument as set forth in claim 1, wherein said processing means comprises means for calculating the percentage of fat present in a body.

10. A near-infrared quantitative analysis instrument for non-invasive measurement of a blood analyte present in a body part of a subject, said analysis instrument comprising:

(a) introducing means including a near-infrared energy source including infrared emitting diodes for introducing near-infrared energy into blood present in a body part of a subject;

(b) detector circuit means for detecting near-infrared energy emerging from the body part, said detecting means producing a signal indicative of said energy emerging from said body part;

(c) means for supplying current to each of said infrared emitting diodes in said introducing means;

(d) current modification means for modifying the current supplied to each infrared emitting diode in response to said signal from said detector circuit means; and

(e) processing means for calculating the electrical signal from said detector circuit means into a signal indicative of the quantity of said blood analyte present in the blood of the subject.

11. The near-infrared analysis instrument as set forth in claim 10, wherein said detector circuit means comprises an analog-to-digital converter which generates a signal representative of the energy emerging from said body part.

12. The near-infrared analysis instrument as set forth in claim 11, wherein said detector circuit means comprises a programmable gain amplifier.

13. The near-infrared analysis instrument as set forth in claim 11, wherein said analog-to-digital converter is a 12-bit analog-to-digital converter.

14. The near-infrared analysis instrument as set forth in claim 11, wherein said current modification means modifies the current to an IRED in response to the signal from said analog-to-digital converter.

15. The near-infrared analysis instrument as set forth in claim 10, wherein said current modification means comprises an infrared emitting diode current control circuit for modifying the current to an infrared emitting diode.

16. The near-infrared analysis instrument as set forth in claim 10, wherein said analysis instrument comprises a housing means for housing at least said introducing means and said detecting means, said housing means comprising a chamber means for enabling said body part of said subject to be exposed to said near-infrared energy, said introducing means and said detecting means being positioned about said chamber means such that near-infrared energy emitted by said introducing means is receivable by said detecting means.

17. The near-infrared analysis instrument as set forth in claim 16, wherein said analysis instrument comprises an insert means for receiving said body part of said subject and for engaging said chamber means.

18. The near-infrared analysis instrument as set forth in claim 10, wherein said analytical instrument. further comprises an energy conservation means for terminating the drain on a power supply to the instrument if a measurement isn'"'"'t taken within a predetermined time period.

19. The near-infrared analysis instrument as set forth in claim 18, wherein said predetermined time period is approximately one minute.

20. A near-infrared quantitative analysis instrument for non-invasive measurement of a blood analyte present in a body part of a subject, said analysis instrument comprising:

(a) introducing means including a near-infrared energy source including infrared emitting diodes for introducing near-infrared energy into blood present in a body part of a subject;

(b) detecting means for detecting near-infrared energy emerging from the body part, said detecting means producing a signal indicative of said energy emerging from said body part;

(c) a housing means for housing at least said introducing means and said detecting means, said housing means comprising a chamber means for enabling said body part of said subject to be exposed to said near-infrared energy, said introducing means and said detecting means being positioned about said chamber means such that near-infrared energy emitted by said introducing means is receivable by said detecting means;

(d) an insert means for receiving said body part of said subject and for engaging said chamber means;

(e) means for supplying current to each of said infrared emitting diodes in said introducing means;

(f) current modification means for modifying the current supplied to each infrared emitting diode in response to said signal from said detection means; and

(g) processing means for calculating the electrical signal from said detection means into a signal indicative of the quantity of said blood analyte present in the blood of the subject.

21. A near-infrared quantitative analysis instrument for non-invasive measurement of a blood analyte present in a body part of a subject, said analysis instrument comprising:

(a) introducing means including a near-infrared energy source including infrared emitting diodes for introducing near-infrared energy into blood present in a body part of a subject;

(b) detector circuit means for detecting near-infrared energy emerging from the body part, said detecting means producing a signal indicative of said energy emerging from said body part;

(c) means for storing an optical signature comprised of optical data corresponding to the body part and/or blood within the body part at a given time;

(d) means for generating a real time optical signature corresponding to stored optical data which makes up the optical signature; and

(e) processing means for comparing the stored optical signature with the real time optical signature, whereby correspondence of the stored optical signature and the real time optical signature results in a condition permitting an analysis to be performed by the instrument.