Method and apparatus for bone morphometry and a morphometric bone assay system

• US 5,365,564 A
• Filed: 10/23/1991
• Issued: 11/15/1994
• Est. Priority Date: 02/23/1989
• Status: Expired due to Fees

• Current Assignee: Teijin Limited
• Original Assignee: Teijin Limited
• Inventors: Kurome, Kanji, Imose, Kazuo, Asahina, Atsushi, Hanaoka, Yasuki, Yashida, Makoto
• Primary Examiner(s): Dzierzynski, Paul M.
• Assistant Examiner(s): BRUCE, DAVID VERNON
• Application Number:
  US07/601,716
• Time in Patent Office: 1,119 Days
• Field of Search: 378/54, 378/55, 378/56, 378/62, 378/901, 364/413.01, 364/413.02, 364/413.13, 364/413.14
• US Class Current: 378/55
• CPC Class Codes: A61B 10/00 Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis vaccination prophylaxis, vaccination therapy A61B17/20; Sex determination; Ovulation-period determination menstruation tables G06C3/00; Throat striking implements
• CPC Class Codes: A61B 6/505 for diagnosis of bone
• CPC Class Codes: A61B 6/583 using calibration phantoms
• CPC Class Codes: G06T 2207/10116 X-ray image
• CPC Class Codes: G06T 2207/30008 Bone
• CPC Class Codes: G06T 7/60 Analysis of geometric attributes

Abstract

A bone-morphometric apparatus (20) is provided with a bone-morphometric data processing unit (32), including at least an image storage unit, such as an image memory (56), a microprocessor unit (60), and an input unit for entering reference points to specify an object measuring region. The data processing unit (32) stores either digital data of an X-ray image (22a) of a sample bone formed on an X-ray film (22) simultaneously with an image of a given standard block (11), obtained by illuminating the X-ray film with illuminating light from a light source (41) and automatically detecting the quantity of light transmitted through the image (22a) by an image detector (42), or digital data of a radiographic image of the sample bone obtained by a radiographic image-forming apparatus (90) in the image storage unit, so as to subject the stored digital data to arithmetic operation, to thereby obtain bone-morphometric data. At least one bone-morphometric apparatus (20) may be connected to a morphometric bone assay apparatus (351) by means of a communications means (350), in order to constitute a morphometric bone assay system.

Claims

1. A bone-morphometric apparatus comprising, in combination:

automatic image read means for automatically reading the bone-morphometric data of the image of a sample bone formed on an X-ray film by irradiating the sample bone together with a given standard matter with X-rays, through the illumination of the image and the detection of the quantity of light transmitted through the image wherein said automatic image read means comprises automatic film feed means for feeding the X-ray film;

linear light source means for emitting light to illuminate the X-ray film; and

linear image detecting means for detecting the quantity of transmitted light transmitted through the X-ray film;

image storage means for storing the bone-morphometric data of the image of the sample bone obtained by the automatic image read means;

arithmetic means for processing the bone-morphometric data of the image stored in the image storage means for bone morphometry; and

bone-morphometric data output means for providing the results of bone morphometry obtained through the operation of the arithmetic means.

2. A bone-morphometric apparatus according to claim 1 further comprising:

picture display means for displaying a picture corresponding to the image of the sample bone represented by the bone-morphometric data obtained by said automatic image read means; and

point input means for entering points to specify reference positions necessary for bone morphometry on the picture of the sample bone displayed on the picture display means.

3. A bone-morphometric apparatus according to claim 2 further comprising case means provided in its front surface with the screen of said picture display means.

4. A bone-morphometric apparatus according to claim 2, wherein said point input means is capable of erasing the points specifying the reference positions necessary for bone morphometry on the picture of the sample bone as well as entering the points.

5. A bone-morphometric apparatus according to claim 2, wherein said point input means comprises mark display means for displaying predetermined marks representing the points on said picture display means in predetermined pictures contrastive to the background, and the mark display means reverses the respective densities of portions for forming the marks in the screen of said picture display means to display the marks contrastive to the background.

6. A bone-morphometric apparatus according to claim 1, wherein the automatic film feed means of said automatic image read means is provided with film feed control means for feeding the X-ray film to recognize the image of the predetermined standard matter and performs control functions so that the image is illuminated by the light emitted by said light source means, and the light source means of said automatic image read means is provided with illuminating light quantity adjusting means for adjusting the quantity of illuminating light so that the quantity of light transmitted through a given portion of the standard matter is in a given light quantity range.

7. A bone-morphometric apparatus according to claim 6, wherein said film feed control means is intermittent feed control means including a stepping motor, and capable of controlling the stepping motor so that the X-ray film is fed intermittently at a fixed rate.

21. A bone-morphometric apparatus according to claim 1, wherein said arithmetic means comprises:

first smoothing means for obtaining a first smoothed density pattern by initially obtaining a plurality of density patterns of said image of the sample bone formed on said X-ray film, along a plurality of different substantially parallel scanning lines in a predetermined object measuring region of said image of the sample bone from said bone-morphometric data read by said automatic image read means, and by subsequently averaging said plurality of density patterns of said image at predetermined points where said the plurality of different scanning lines cross a line extending longitudinally through said X-ray film image, so as to be substantially perpendicular to said plurality of scanning lines; and

pattern data converting means for converting the density data of the first smoothed density pattern into those expressed by the thickness of the standard matter to obtain a converted pattern.

22. A bone-morphometric apparatus according to claim 21, wherein said arithmetic means further comprises a second smoothing means for obtaining a second smoothed density pattern by averaging values of said converted pattern at a plurality of predetermined points on said scanning lines, said second smoothed density pattern being processed for said bone-morphometry of said sample bone.

23. A bone-morphometric apparatus according to claim 21, wherein said pattern data converting means converts the density pattern into a thickness pattern represented by the thickness of the standard matter on the basis of the relation between the thickness of the standard matter and the quantity of transmitted light determined by measuring the quantity of light transmitted through the image of the standard matter formed on the X-ray film.

8. A bone-morphometric apparatus comprising, in combination:

automatic image read means for automatically reading the bone-morphometric data of the image of a sample bone formed on an X-ray film by irradiating the sample bone together with a given standard matter with X-rays, through the illumination of the image and the detection of the quantity of light transmitted through the image wherein said automatic image read means comprises;

light source means for emitting light for illuminating the X-ray film;

image detecting means for detecting the quantity of transmitted light transmitted through the X-ray film;

region search means for searching the image of the given standard matter for a region that transmits a quantity of light meeting predetermined conditions;

first decision means for making a decision as to whether or not a range of the quantity of transmitted light for an object measuring region for bone morphometry is included in the range of the quantity of transmitted light for the region in the image of the standard matter;

second decision means for making a decision as to whether or not the quantity of light transmitted through the object measuring region and the quantity of light transmitted through the standard matter meet a given resolution; and

illuminating light adjusting means for adjusting the quantity of light to be emitted by said light source means on the basis of the decision made by the first decision means;

image storage means for storing the bone-morphometric data of the image of the sample bone obtained by the automatic image read means;

arithmetic means for processing the bone-morphometric data of the image stored in the image storage means for bone morphometry; and

bone-morphometric data output means for providing the results of bone morphometry obtained through the operation of the arithmetic means.

9. A bone-morphometric apparatus according to claim 8, wherein said light source means comprises:

first means for obtaining the quantity I of transmitted light transmitted through a portion of the standard matter, greater than and nearly the same as the maximum quantity of light transmitted through said object measuring region when increasing the quantity of illuminating light to be emitted;

second means for adjusting the quantity of illuminating light to be emitted so that the quantity I of transmitted light approaches a given maximum quantity I_max ;

third means for searching the object measuring region for an area which transmits a quantity of transmitted light exceeding the given quantity I_max in reducing the quantity of illuminating light to be emitted; and

fourth means for adjusting the quantity of illuminating light to be emitted on the basis of an appropriate quantity of illuminating light estimated taking into consideration the size of the area.

10. A bone-morphometric apparatus according to claim 8, wherein said automatic image read means includes an automatic film feed means for feeding the X-ray film, and

said bone-morphometric apparatus comprises:

picture display means for displaying a picture corresponding to the image of the sample bone represented by the bone-morphometric data obtained by said automatic image read means;

point input means for entering points to specify reference positions on the picture of the sample bone displayed on the picture display means;

storage means for storing the points specifying the reference positions; and

another point input means for specifying new points on the basis of the points specifying the reference positions, stored in the storage means when the image of the standard matter and the object measuring region in the image of the sample bone are read automatically by said automatic image read means by using an adjusted quantity of illuminating light in performing again the bone morphometry of the image of the sample bone after adjusting the quantity of illuminating light.

11. A bone-morphometric apparatus comprising, in combination:

automatic image read means for automatically reading the bone-morphometric data of the image of a sample bone formed on an X-ray film by irradiating the sample bone together with a given standard matter with X-rays, through the illumination of the image and the detection of the quantity of light transmitted through the image wherein said automatic image read means comprises;

automatic film feed means for automatically feeding the X-ray film;

linear light source means extended perpendicularly to a film feed direction in which the X-ray film is fed, to emit illuminating light for illuminating the X-ray film;

linear image detecting means for detecting the quantity of transmitted light transmitted through the X-ray film; and

image read region setting means for setting a distance a from a reference position with respect to the film feed direction for the skipping feed of the X-ray film, a distance b for the image reading feed of the X-ray film, on the extension of the distance a, a distance c from a reference position with respect to a direction perpendicular to the film feed direction along the direction perpendicular to the film feed direction and an image scanning distance d on the extension of the distance c;

image storage means for storing the bone-morphometric data of the image of the sample bone obtained by the automatic image read means;

arithmetic means for processing the bone-morphometric data of the image stored in the image storage means for bone morphometry; and

bone-morphometric data output means for providing the results of bone morphometry obtained through the operation of the arithmetic means.

12. A bone-morphometric apparatus according to claim 11, wherein said automatic film feed means comprises:

feed roller means disposed so as to nip the X-ray film;

a stepping motor for driving the feed roller means;

pulse signal control means for controlling a pulse signal for driving the stepping motor, and

converting means for converting the distance a into a corresponding pulse signal for driving the stepping motor for the skipping feed of the X-ray film, converting the distance b into a number of scanning lines for which said linear image detecting means performs image detecting operation, and converting the distances c and d respectively into numbers of detecting elements of said linear image detecting means.

13. A bone-morphometric apparatus according to claim 11, wherein said image read region setting means comprises:

external input means for entering the distances a, b, c and d; and

storage means for storing the distances a, b, c and d entered by the external input means.

14. A bone-morphometric apparatus according to claim 11, wherein the X-ray film has two object measuring regions respectively for the standard matter and the sample bone, and an image for calibration, said automatic image read means has object region setting means for setting the distances a, b, c and d for each of the object regions, and said image storage means has image storage means for storing images read from the two object regions.

15. A bone-morphometric apparatus comprising, in combination:

automatic image read means for automatically reading the bone-morphometric data of the image of a sample bone formed on an X-ray film by irradiating the sample bone together with a given standard matter with X-rays, through the illumination of the image and the detection of the quantity of light transmitted through the image;

wherein said automatic image read means comprises;

automatic film feed means for automatically feeding the X-ray film;

linear light source means extended perpendicularly to a film feed direction in which the X-ray film is fed, to emit illuminating light for illuminating the X-ray film;

linear image detecting means for detecting the quantity of transmitted light transmitted through the X-ray film;

coarse image-read means for coarsely reading images including those of the standard matter and the sample bone formed in a wide object measuring region to obtain the data of picture elements in a coarse distribution while the X-ray film is being fed by the automatic film feed means;

display means for displaying a coarse picture represented by the data obtained by the coarse image-read means;

object measuring region specifying means for specifying narrow object measuring regions respectively including the respective small portions of the images of the standard matter and the sample bone in the coarse picture displayed by the display means; and

minute image-read means for reading portions of the images of the standard matter and the sample bone in the narrow object measuring regions specified by the object measuring region specifying means in a dense picture element distribution by said image detecting means while the X-ray film is being fed by said automatic film feed means;

image storage means for storing the bone-morphometric data of the image of the sample bone obtained by the automatic image read means;

arithmetic means for processing the bone-morphometric data of the image stored in the image storage means for bone morphometry; and

bone-morphometric data output means for providing the results of bone morphometry obtained through the operation of the arithmetic means.

16. A bone-morphometric apparatus according to claim 15, wherein said coarse image-read means reads the data of picture elements in a thin distribution with respect to the film feed direction while the X-ray film is being fed at a higher feed speed by said automatic film feed means.

17. A bone-morphometric apparatus according to claim 16, wherein said display means for displaying the coarse picture expressed by the data of the picture elements obtained by coarse image-reading displays the picture in a degree of coarseness with respect to a direction perpendicular to the film feed direction substantially the same as the degree of coarseness with respect to the film feed direction.

18. A bone-morphometric apparatus according to claim 17, wherein said object measuring region specifying means specifies the narrow regions including the portions of the pictures of the standard matter and the sample bone by locating a cursor on the pictures displayed on the display means for displaying the coarse picture.

19. A bone-morphometric apparatus according to claim 15 further comprising data converting means for converting the narrow object measuring regions specified by said object measuring region specifying means into data representing film feed distances and read ranges with respect to a direction perpendicular to the film feed direction to make said minute image-read means operate for the minute image-reading of the data of picture elements distributed in a dense distribution in the specified narrow object measuring regions on the basis of data provided by the data converting means.

20. A bone-morphometric apparatus comprising, in combination:

automatic image read means for automatically reading the bone-morphometric data of the image of a sample bone formed on an X-ray film by irradiating the sample bone together with a given standard matter with X-rays, through the illumination of the image and the detection of the quantity of light transmitted through the image wherein said automatic image read means comprises;

light source means for emitting light to illuminate the X-ray film;

image detecting means for detecting the quantity of transmitted light transmitted through the X-ray film;

light quantity control means for controlling the quantity of illuminating light for illuminating the X-ray film;

detecting means for detecting a portion of the image of the standard matter corresponding to the thicker end of the standard matter by measuring the quantity of light transmitted through a portion of the image of the standard matter corresponding to the vicinity of the thickest end of the standard matter, during the application of a given smaller quantity of L₀ of illuminating light to the same portion of the image corresponding to the vicinity of the thickest end of the standard matter; and

measuring means for measuring the quantity of transmitted light transmitted through the image of the standard matter formed on the X-ray film, during the application of a given larger quantity L of illuminating light to the image of the standard matter, to determine the relation between the quantity of transmitted light and the distance from the thicker end of the image of the standard matter;

image storage means for storing the bone-morphometric data of the image of the sample bone obtained by the automatic image read means;

arithmetic means for processing the bone-morphometric data of the image stored in the image storage means for bone morphometry; and

bone-morphometric data output means for providing the results of bone morphometry obtained through the operation of arithmetic means.

24. A morphometric bone assay system comprising:

a bone-morphometric apparatus for the bone morphometric sample bone;

first transmission means for transmitting bone-morphometric data obtained by the bone morphometry of the sample bone as output data;

morphometric bone assay means for storing the bone-morphometric data transmitted by the first transmission means thereto and for performing the morphometric bone assay of the sample bone by using the stored bone-morphometric data in combination with corresponding previously stored bone-morphometric data and, if need be, other stored data; and

second transmission means for transmitting the results of the morphometric bone assay of the sample bone provided by the morphometric bone assay means to the bone-morphometric apparatus;

wherein said bone-morphometric apparatus is provided with self-diagnostic means for diagnosing its own operating condition.

25. A morphometric bone assay system according to claim 24, wherein said first and second transmission means utilize telephone circuits.

26. A morphometric bone assay system according to claim 24, wherein said morphometric bone assay means is a single morphometric bone assay apparatus, and a plurality of bone-morphometric apparatus like said bone-morphometric apparatus are connected through said first and second transmission means to the morphometric bone assay apparatus.

27. A morphometric bone assay system according to claim 24, wherein said bone-morphometric apparatus comprises:

automatic image read means for automatically reading the bone-morphometric data of the image of a sample bone formed on an X-ray film by irradiating the sample bone together with a given standard matter with X-rays, through the illumination of the image and the detection of the quantity of transmitted light transmitted through the image;

image storage means for storing the bone-morphometric data of the image of the sample bone obtained by the automatic image read means;

arithmetic means for processing the bone-morphometric data of the image stored in the image storage means for bone morphometry; and

bone-morphometric data output means for providing the results of bone morphometry obtained through the operation of the arithmetic means.

28. A morphometric bone assay system according to claim 24, wherein said bone-morphometric apparatus comprises:

image storage means for storing the radiographic image of the sample bone formed by irradiating the sample bone with radioactive rays and recording the radioactive rays transmitted through the sample bone;

arithmetic means for processing image data representing the radiographic image of the sample bone for bone morphometry; and

bone-morphometric data output means for providing the results of the operation of the bone-morphometric data.

29. A bone-morphometric method comprising:

an image reading step of reading a radiographic image of a sample bone formed by irradiating the sample bone with radioactive rays and recording the transmitted radioactive rays transmitted through the sample bone;

a pattern smoothing step of obtaining a first smoothed density pattern by obtaining a plurality of density patterns of said radiographic image recorded with respect to a predetermined object measuring region thereof along a plurality of different scanning lines, and by averaging the plurality of density patterns of said radiographic image at predetermined points where the plurality of substantially parallel scanning lines cross a line extending longitudinally through said radiographic image, so as to be substantially perpendicular to said plurality of scanning lines;

a data converting step of converting the data representing the first smoothed density pattern into those represented by the thickness of a standard matter to obtain a converted density pattern; and

an arithmetic step of operating the data representing the converted density pattern for the bone morphometry of the sample bone.

30. A bone-morphometric method according to claim 29, wherein a second smoothed density pattern is obtained by averaging the data of the converted density pattern at a plurality of points in the vicinity of the scanning line, in order to obtain said converted density pattern after the data converting step, and the data of said second smoothed density pattern is used in the arithmetic step.

31. A bone-morphometric method according to claim 29, wherein the image data of the image of the sample bone formed together with that of a given standard matter having varying thickness on an X-ray film is obtained in the image read step by illuminating the image of the sample bone and detecting the quantity of light transmitted through the image of the sample bone, the data of the density pattern is converted into those expressed by the thickness of the standard matter on the basis of the relation between the thickness of the standard matter and the quantity of transmitted light in the data converting step.

32. A bone-morphometric method for bone morphometry of a sample bone, comprising illuminating an X-ray film carrying respective images of a sample bone and a given standard matter having varying thickness formed simultaneously thereon, and using a quantity of light transmitted through a X-ray film, characterized in:

determining a region in the image of the standard matter transmitting a quantity of transmitted light meeting a given condition;

making a first decision as to whether or not the range for the quantity of light transmitted through an object measuring region is included in a range for the quantity of light transmitted through a region in the image of the standard matter determined in the region determining step;

making a second decision as to whether or not the quantity of light transmitted through the object measuring region and the corresponding quantity of light transmitted through the image of the standard matter meet a given resolution; and

adjusting the quantity of illuminating light to be applied to the X-ray film according to the second decision.

33. A bone-morphometric method according to claim 32, wherein, a third decision is made on whether or not the gamma value of the object measuring region is greater than a predetermined value, after the second decision.

34. A bone-morphometric method according to claim 32, wherein in increasing the quantity of illuminating light, a quantity I of transmitted light transmitted through the standard matter greater than and nearly equal to the maximum quantity of transmitted light transmitted through the object measuring region is determined, and the quantity of the illuminating light is adjusted so that the quantity I of transmitted light is not greater than and nearly equal to a predetermined value I_max.

35. A bone-morphometric method according to claim 32, wherein, in reducing the quantity of illuminating light, a portion of the object measuring region transmitting a quantity of transmitted light exceeding the predetermined value I_max is detected, an appropriate quantity of illuminating light is estimated taking into consideration the size of the portion, and the quantity of illuminating light is adjusted to the estimated appropriate quantity of illuminating light.

36. A bone-morphometric method for the bone morphometry of a sample bone, comprising illuminating an X-ray film carrying the respective images of a sample bone and a give standard matter having varying matter formed simultaneously thereon, and using a quantity of transmitted light transmitted through the X-ray film, characterized in:

applying a predetermined smaller quantity L₀ of illuminating light to a portion of an image of the standard matter corresponding to the vicinity of the thicker end of the standard matter, detecting the quantity of transmitted light transmitted through the portion of the image of the standard matter to detect the thicker end of the image of the standard matter, applying a predetermined larger quantity L of illuminating light greater than the quantity L₀ to the image of the standard matter to determine the relationship between the thickness of the standard matter and the gradation of the image of the same on the basis of the relation between the quantity of light transmitted through the image of the standard matter and the distance from the detected end of the same.