Cardiac signal sensing device having sensitivity automatically controlled in response to metabolic demand

• US 5,365,932 A
• Filed: 09/02/1993
• Issued: 11/22/1994
• Est. Priority Date: 09/02/1993
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Telectronics Pacing Systems, Inc (Abbott Laboratories Incorporated)
• Inventors: Greenhut, Saul E.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US08/116,135
• Time in Patent Office: 446 Days
• Field of Search: 128/696, 128/700, 128/706, 128/708
• US Class Current: 600/508
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence

Abstract

A pacemaker automatically adjusts sensitivity as a function of metabolic demand. The amplitude of cardiac signals is naturally reduced during exercise. The pacemaker measures a physiological parameter to determine the patient'"'"'s metabolic demand. In response to increases in the patient'"'"'s metabolic demand the sensitivity is increased and in response to decreases in the patient'"'"'s metabolic demand the sensitivity is decreased.

Claims

1. A patient heartbeat sensing apparatus comprising:

first means for measuring a physiological parameter of the patient and for providing an output signal which is responsive to the patient'"'"'s metabolic demand as indicated by the measured parameter;

second means for sensing a signal which is responsive to cardiac activity and noise;

third means, having an adjustable sensitivity, for operating on said cardiac activity and noise signal, to determine therefrom the occurrence of a natural heartbeat; and

fourth means for adjusting the sensitivity of said third means in response to said metabolic demand output signal, being responsive to increases in the patient'"'"'s metabolic demand by increasing said sensitivity, and being responsive to decreases in the patient'"'"'s metabolic demand by decreasing said sensitivity.

2. An apparatus according to claim 1, wherein:

said third and fourth means have a mode of operation of;

comparing signals from said second means against a variable sensing threshold value for determining the occurrence of a natural heartbeat; and

setting said sensing threshold value

(i) in response to increases in the patient'"'"'s metabolic demand by decreasing said sensing threshold value, and

(ii) in response to decreases in the patient'"'"'s metabolic demand by increasing said sensing threshold value.

3. An apparatus according to claim 2, wherein:

said third and fourth means have a further mode of operation of;

setting said variable sensing threshold value to an initial threshold value in response to the occurrence of a heartbeat;

initiating the timing of a relative refractory period, and

in response to said cardiac activity and noise signal exceeding said variable sensing threshold value during said relative refractory period, again initiating the timing of a relative refractory period and increasing the variable sensing threshold value, and

in response to a lapse of such relative refractory period without said cardiac activity and noise signal exceeding said variable sensing threshold value, initiating the timing of a heartbeat sensing interval;

at the start of a heartbeat sensing interval setting the variable sensing threshold value as a function of both the variable sensing threshold value at the end of the preceding relative refractory period and the patient'"'"'s metabolic demand; and

in response to said cardiac activity and noise signal exceeding the variable sensing threshold value during a heartbeat sensing interval, determining that a heartbeat has occurred.

4. An apparatus according to claim 2, wherein:

said third and fourth means have a further mode of operation of;

in response to the detection of a natural heartbeat, deriving a value which is representative of the average of the peak amplitudes of the cardiac activity and noise signal during a preceding interval of time which is at least a few cardiac cycles long;

setting said variable sensing threshold value to an initial threshold value in response to the occurrence of a heartbeat;

initiating the timing of a relative refractory period;

in response to said cardiac activity and noise signal exceeding said variable sensing threshold value during said relative refractory period, again initiating the timing of a relative refractory period and increasing the variable sensing threshold value;

in response to a lapse of the relative refractory period without said cardiac activity and noise signal exceeding said variable sensing threshold value, initiating the timing of a heartbeat sensing interval;

at the start of a heartbeat sensing interval setting the variable sensing threshold value as a function of any of the three of;

(i) the variable sensing threshold value at the end of the preceding relative refractory period,

(ii) the average measured peak amplitude of the cardiac activity and noise signal, and

(iii) the patient'"'"'s metabolic demand, and

in response to said cardiac activity and noise signal exceeding the variable sensing threshold value during a heartbeat sensing interval, determining that a heartbeat has occurred.

5. An apparatus according to claim 2, wherein:

said third and fourth means have a further mode of operation of;

setting said variable sensing threshold value to an initial threshold value in response to the occurrence of a heartbeat, and successively increasing said threshold value to a final value as the cardiac activity and noise signal increases, until the final threshold value represents the noise level in said cardiac activity and noise signal;

in response to said final threshold value representing the noise level in said cardiac activity and noise signal, initiating the timing of a heartbeat sensing interval;

at the start of a heartbeat sensing interval, setting a threshold value which is a function of both said final threshold level value and the patient'"'"'s metabolic demand; and

in response to said cardiac activity and noise signal exceeding said threshold value during a heartbeat sensing interval, indicating the occurrence of a heartbeat.

6. An apparatus according to claim 2, wherein:

said third and fourth means have a further mode of operation of;

in response to said third means detecting a natural heartbeat, measuring the peak amplitude of said cardiac activity and noise signal;

deriving a value representative of the average of the measured peak amplitudes of said cardiac activity and noise signal during a preceding time interval which is at least a few cardiac cycles long;

setting said variable sensing threshold value to an initial threshold value in response to the occurrence of a heartbeat, and successively increasing the threshold value to a final value as the cardiac activity and noise signal increases, until the final threshold value represents the noise level in said cardiac activity and noise signal;

in response to said final threshold value representing the noise level in said cardiac activity and noise signal, initiating the timing of heartbeat sensing interval;

at the start of a heartbeat sensing interval setting a threshold value which is a function of one or more of;

(i) the final threshold level,

(ii) the average measured peak amplitudes of said cardiac activity and noise signal, and

(iii) the patient'"'"'s metabolic demand, and

in response to the cardiac activity and noise signal exceeding said threshold value during the timing of a heartbeat sensing interval, indicating the occurrence of a heartbeat.

7. An apparatus according to claim 1, wherein:

said third means includes means for amplifying said cardiac activity and noise signal;

said third and fourth means have a further mode of operation of;

in response to changes in the first means physiological parameter measurement, said fourth means selectively varies said third means for amplifying gain;

increasing said gain value in response to increase in the patient'"'"'s metabolic demand; and

decreasing said gain value in response to decrease in the patient'"'"'s metabolic demand.

8. An apparatus according to claim 7, wherein:

said third and fourth means have a further mode of operation of;

in response to the detection of a natural heartbeat by said third means, measuring the peak amplitude of said cardiac activity and noise signal;

deriving a value which is representative of the measured peak amplitudes of said cardiac activity and noise signal during a preceding time interval which is at least a few cardiac cycles long; and

adjusting said gain in response to said derived peak amplitude value.

9. An apparatus according to claim 8, wherein:

said third means includes

comparator means for comparing signals from said second means against a sensing threshold value for determining the occurrence of a natural heartbeat; and

said fourth means;

in response to increase in the patient'"'"'s metabolic demand, decreases said sensing threshold value, and

in response to decrease in the patient'"'"'s metabolic demand, increases said sensing threshold value.

10. An apparatus according to claim 9, wherein:

said third and fourth means have a further mode of operation of;

in response to the occurrence of a heartbeat, setting said variable sensing threshold value to an initial threshold value;

initiating the timing of a relative refractory period;

in response to said cardiac activity and noise signal exceeding said variable sensing threshold value during said relative refractory period, initiating again the timing of a relative refractory period, and increasing the variable sensing threshold value;

in response to the lapse of the relative refractory period without said cardiac activity and noise signal having exceeded said variable sensing threshold value, initiating the timing of a heartbeat sensing interval;

at the start of the heartbeat sensing interval, setting a variable sensing threshold value as a function of both;

(i) the variable sensing threshold value at the end of the preceding relative refractory period, and

(ii) the patient'"'"'s metabolic demand; and

in response to said cardiac activity and noise signal exceeding the variable sensing threshold value during the timing of a heartbeat sensing interval, indicating the occurrence of a heartbeat.

11. An apparatus according to claim 9, wherein:

said third and fourth means have a further mode of operation of;

in response to the detection of a natural heartbeat by said third means measuring the peak amplitude of said cardiac activity and noise signal;

deriving a value representative of the average of the measured peak amplitudes of said cardiac activity and noise signal during a preceding time interval which is at least a few cardiac cycles long;

in response to the detection of a natural heartbeat setting said variable sensing threshold value to an initial threshold value;

initiating the timing of a relative refractory period;

in response to said cardiac activity and noise signal exceeding said variable sensing threshold value during said relative refractory period, initiating again the timing of a relative refractory period and increasing the variable sensing threshold value;

in response to the lapse of the relative refractory period without said cardiac activity noise signal exceeding said variable sensing threshold value, initiating a heartbeat sensing interval;

at the start of a heartbeat sensing interval, setting a variable sensing threshold value as a function of the three of;

(i) the variable sensing threshold value at the end of the preceding relative refractory period,

(ii) the average measured peak amplitude of the cardiac activity and noise signal, and

(iii) the patient'"'"'s metabolic demand; and

in response to said cardiac activity and noise signal exceeding the variable sensing threshold value during a heartbeat sensing interval, indicating the occurrence of a heartbeat.

12. An apparatus according to claim 9, wherein:

said third and fourth means have a further mode of operation of;

in response to the occurrence of a heartbeat, setting said variable sensing threshold value to an initial threshold value and successively increasing the threshold value to a final value as the cardiac activity and noise signal increases until the final threshold value represents the noise level in said cardiac activity and noise signal;

in response to said final threshold value representing said noise level, initiating the timing of a heartbeat sensing interval;

at the start of a heartbeat sensing interval setting a threshold value which is a function of both;

(i) said final threshold level, and

(ii) the patient'"'"'s metabolic demand, and

in response to the cardiac activity and noise signal exceeding said threshold value during the timing of a heartbeat sensing interval, indicating the occurrence of a heartbeat.

13. An apparatus according to claim 9, wherein:

said third and fourth means have a further mode of operation of;

in response to the detection of a natural heartbeat by said third means, measuring the peak amplitude of said cardiac activity and noise signal;

deriving a value representative of the average of the measured peak amplitudes of said cardiac activity and noise signal during a preceding time interval which is at least a few cardiac cycles long;

in response to the occurrence of a heartbeat, setting said variable threshold value to an initial threshold value and successively increasing the threshold value to a final value as the cardiac activity and noise signal increases, until the final threshold value represents the noise level in said cardiac activity and noise signal;

in response to said final value representing the noise level in said cardiac activity and noise signal, initiating the timing of a heartbeat sensing interval;

at the start of a heartbeat sensing interval setting a threshold value which is a function of the three of;

(i) the final threshold level,

(ii) the average measured peak amplitude of said cardiac activity and noise signal, and

(iii) the patient'"'"'s metabolic demand; and

in response to the cardiac activity and noise signal exceeding said threshold value during a heartbeat sensing interval, indicating the occurrence of a heartbeat.

14. An apparatus according to claim 1, wherein:

said third and fourth means have a further mode of operation of;

in response to both the patient'"'"'s metabolic demand being substantially stable and the detection of a natural heartbeat by said third means, measuring the peak amplitude of said cardiac activity and noise signal;

deriving a value representative of the average of the measured peak amplitudes during a preceding time interval which is at least a few cardiac cycles long; and

varying the sensitivity of said third means in response to said derived value.

15. A method of operating a patient heartbeat sensing apparatus, comprising:

measuring a physiological parametr of the patient which is representative of the metabolic demand of the patient;

sensing a signal which is representative of the cardiac electrical activity of the patient;

adjusting the sensitivity of the apparatus to said sensed cardiac signal;

(i) by increasing said sensitivity in response to a measured increase in said metabolic demand, and

(ii) by decreasing said sensitivity in response to a measured decrease in said metabolic demand.

16. A method according to claim 15 wherein:

said sensing of the cardiac signal includes comparing said cardiac signal to a sensing threshold value to determine whether or not said cardiac signal represents the occurrence of a natural heartbeat; and

said sensitivity adjustment includes adjusting said sensing threshold value;

(i) by decreasing said sensing threshold value to increase said sensitivity, and

(ii) by increasing said sensing threshold value to decrease said sensitivity.