Automatic fibrillation detector and defibrillator apparatus and method

• US 5,366,486 A
• Filed: 02/09/1993
• Issued: 11/22/1994
• Est. Priority Date: 06/25/1992
• Status: Expired due to Fees

• Current Assignee: ADVANCED RESEARCH & TECHNOLOGY INSTITUTE
• Original Assignee: Indiana University Foundation
• Inventors: Adams, David E., Zipes, Doulgas P.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US08/015,650
• Time in Patent Office: 651 Days
• Field of Search: 607/14, 607/2, 607/4, 607/5, 128/705, 128/702, 128/696, 128/708
• US Class Current: 607/5
• CPC Class Codes: A61N 1/395 for treating atrial fibrillation
• CPC Class Codes: A61N 1/3956 Implantable devices for applying electric shocks to the heart, e.g. for cardioversion

Abstract

The present invention involves an apparatus and method for detecting and treating fibrillation in the heart. Electrodes sense electrical activity in two distinct locations of the heart. The electrocardiac activations are monitored and the interval between activations at the two locations is measured and checked for variation. Upon detection of significant variation in the length of the intervals, the fibrillation condition is determined and a defibrillator is activated, so that a defibrillating shock may be delivered to the heart. For atrial fibrillation, the first defibrillating shock is relatively low and is increased until the fibrillation is no longer detected.

Claims

1. A method of detecting fibrillation comprising the steps of:

locating two electrodes at two different positions in the heart, one electrode in the right atrium to monitor local electrical signals, and locating the other electrode in the coronary sinus proximal to the left atrium to monitor local electrical signals;

monitoring said electrical signals detected by the two electrodes to determine the occurrence of an activation;

measuring the time interval between said activations; and

comparing the measured time interval with a reference time interval value and calculating whether the measured time interval substantially deviates from the reference time interval value to thereby ascertain the presence of fibrillation.

2. The method of claim 1 wherein said reference time interval value is a stored value of a previously determined time interval.

3. The method of claim 1 further comprising the step of storing a plurality of said measured time interval values, and said comparing step includes determining the frequency of deviation from said reference time interval value.

4. The method of claim 3 further comprising the step of comparing said frequency of deviation with a predetermined frequency to ascertain the presence of a fibrillation condition.

5. The method of claim 1 further comprising the step of storing a plurality of said measured time interval values, and said comparing step includes comparing each of said plurality of measured time interval values with the preceding one of said plurality of measured time interval values, said comparing step also includes determining how many of said plurality of measured time interval values substantially deviate from the preceding said measured time interval to determine the frequency of deviation, and said comparing step further includes comparing said frequency of deviation with a reference frequency to ascertain the presence of a fibrillation condition.

6. The method of claim 1 further comprising the step of sensing cycles on one of the electrodes, and the step of determining if an activation was sensed by the other electrode during each said cycle.

7. The method of claim 6 further comprising the step of recording each said cycle in which no activation was sensed by the other electrode.

8. The method of claim 1 wherein said monitoring step includes determining when the absolute value of the electrical signal exceeds a sensitivity level to indicate an activation.

9. The method of claim 8 wherein after an activation is indicated, said monitoring step further includes disregarding the electrical signal for a refractory period before again monitoring the electrical signals.

10. A method of detecting fibrillation comprising the steps of:

locating two electrodes at two different positions in the atrium, each electrode being adapted to sense electrical signals;

monitoring said electrical signals detected by the two electrodes to determine the occurrence of an activation;

measuring the time interval between said activations;

comparing the measured time interval with a reference time interval value and calculating whether the measured time interval substantially deviates from the reference time interval value;

determining the presence of fibrillation based upon whether a substantial deviation is calculated in comparing step.

11. A method of detecting and treating fibrillation comprising the steps of:

locating two electrodes at two different positions in the atrium, each electrode being adapted to sense electrical signals;

monitoring said electrical signals detected by the two electrodes to determine the occurrence of an activation;

measuring the time interval between said activations;

comparing the measured time interval with a reference time interval value and calculating whether the measured time interval substantially deviates from the reference time interval value to thereby ascertain the presence of fibrillation; and

if fibrillation is indicated, delivering defibrillation shocks to the heart with the electrodes.

12. The method of claim 11 wherein said reference time interval value is a stored value of a previously determined time interval.

13. The method of claim 11 further comprising the step of storing a plurality of said measured time interval values, and said comparing step includes determining the frequency of deviation from said reference time interval value.

14. The method of claim 13 further comprising the step of comparing said frequency of deviation with a predetermined frequency to ascertain the presence of a fibrillation condition.

15. The method of claim 11 further comprising the step of storing a plurality of said measured time interval values, and said comparing step includes comparing each of said plurality of measured time interval values with the preceding one of said plurality of measured time interval values, said comparing step also includes determining how many of said plurality of measured time interval values substantially deviate from the preceding said measured time interval to determine the frequency of deviation, and said comparing step further includes comparing said frequency of deviation with a reference frequency to ascertain the presence of a fibrillation condition.

16. The method of claim 11 further comprising the step of sensing cycles on one of the electrodes, and the step of determining if an activation was sensed by the other electrode during each said cycle.

17. The method of claim 16 further comprising the step of recording each said cycle in which no activation was sensed by the other electrode.

18. The method of claim 11 wherein said step of delivering defibrillation shocks comprises the steps of:

delivering a relatively low level defibrillation shock;

checking for the continued presence of fibrillation;

if fibrillation continues to exist then increasing the level of defibrillation shock, delivering the increased defibrillation shock, and checking for the continued presence of fibrillation until no fibrillation is apparent.

19. The method of claim 11 wherein said locating step includes locating one electrode in the right atrium to monitor local electrical signals and locating the other electrode in the coronary sinus proximate to the left atrium to monitor local electrical signals.

20. The method of claim 11 wherein said monitoring step includes determining when the absolute value of the electrical signal exceeds a sensitivity level to indicate an activation.

21. The method of claim 20 wherein after an activation is indicated, said monitoring step further includes disregarding the electrical signal for a refractory period before again monitoring the electrical signals.

22. An apparatus for detecting arrhythmia, the apparatus adapted for use on a heart, said apparatus comprising:

first and second electrodes adapted to contact the heart and sense electrical signals from the heart, said electrodes being disposed at two different locations;

means for monitoring said electrical signals detected by said first and second electrodes to determine the occurrence of an activation, said monitoring means including means for measuring the time interval between said activations, said monitoring means further including means for disregarding the electrical signal after an activation is indicated for a refractory period before again monitoring the electrical signal; and

means for comparing the measured time interval with a reference time interval value and calculating whether the measured time interval substantially deviates from the reference time interval value, said comparing means including means for indicating the presence of a fibrillation condition in the heart.

23. The apparatus of claim 22 further comprising means for storing a measured time interval value as said reference time interval value.

24. The apparatus of claim 22 further comprising means for storing a plurality of measured time values, and said comparing means includes means for determining the frequency of deviation from said reference time interval value.

25. The apparatus of claim 24 wherein said comparing means includes means for comparing said frequency of deviation with a reference frequency to ascertain the presence of fibrillation.

26. The apparatus of claim 22 further comprising means for storing a plurality of measured time interval values, said comparing means includes means for comparing each of said plurality of measured time interval values with the preceding one of said plurality of measured time interval values, said comparing means also includes means for determining how many of said plurality of measured time interval values substantially deviate from the preceding said measured time interval value to determine the frequency of deviation, and said comparing means further includes means for comparing the frequency of deviation with a reference frequency to ascertain the presence of a fibrillation condition.

27. The apparatus of claim 22 further comprising means for sensing cycles on said first electrode and means for determining if an activation was sensed by said second electrode during each said cycle.

28. The apparatus of claim 27 further comprising means for recording each said cycle in which no activation was sensed by said second electrode.

29. The apparatus of claim 22 wherein said electrodes have a size and shape capable of being disposed in the atrium.

30. The apparatus of claim 22 wherein said first electrode has a size and shape capable of being disposed in the right atrium and has means for detecting local electrical signals, and said second electrode has a size and shape capable of being disposed in the coronary sinus proximate to the left atrium and has means for detecting local electrical signals.

31. The apparatus of claim 22 wherein said monitoring means determines when the absolute value of the electrical signal exceeds a sensitivity level to determine the occurrence of an activation.

32. The apparatus of claim 22 wherein said apparatus has a size and shape capable of being implanted in the human body.

33. An apparatus for detecting and treating arrhythmia, the apparatus adapted for use on a heart, said apparatus comprising:

first and second electrodes adapted to contact the heart and sense electrical signals from the heart, said electrodes being disposed at two different locations;

means for monitoring said electrical signals detected by said first and second electrodes to determine the occurrence of an activation, said monitoring means including means for measuring the time interval between said electrical activations, said monitoring means further including means for disregarding the electrical signal after an activation is indicated for a refractory period before again monitoring the electrical signal;

means for comparing the measured time interval with a reference time interval value and calculating whether the measured time interval substantially deviates from the reference time interval value, said comparing means including means for indicating the presence of a fibrillation condition in the heart; and

means for delivering defibrillating shocks to the heart, said defibrillating means being responsive to said indicating means.

34. The apparatus of claim 33 further comprising means for storing a measured time interval value as said reference time interval value.

35. The apparatus of claim 33 further comprising means for storing a plurality of measured time values, and said comparing means includes means for determining the frequency of deviation from said reference time interval value.

36. The apparatus of claim 35 wherein said comparing means includes means for comparing said frequency of deviation with a reference frequency to ascertain the presence of fibrillation.

37. The apparatus of claim 33 further comprising means for storing a plurality of measured time interval values, said comparing means includes means for comparing each of said plurality of measured time interval values with the preceding one of said plurality of measured time interval values, said comparing means also includes means for determining how many of said plurality of measured time interval values substantially deviate from the preceding said measured time interval value to determine the frequency of deviation, and said comparing means further includes means for comparing the frequency of deviation with a reference frequency to ascertain the presence of a fibrillation condition.

38. The apparatus of claim 33 further comprising means for sensing cycles on said first electrode and means for determining if an activation was sensed by said second electrode during each said cycle.

39. The apparatus of claim 38 further comprising means for recording each said cycle in which no activation was sensed by said second electrode.

40. The apparatus of claim 33 wherein said delivering means is coupled to at least one of said first and second electrodes for delivering said defibrillating shocks.

41. The apparatus of claim 33 wherein said delivering means includes means for applying a low level defibrillating shock, means for checking for the continued presence of the fibrillation condition, and means for increasing the level of said defibrillating shock and applying said defibrillating shock until no fibrillation is apparent.

42. The apparatus of claim 41 wherein said applying means initially provides a defibrillating shock of about 0.1 joules, and said increasing means increases the level of said defibrillating shock by about 0.1 joules.

43. The apparatus of claim 33 wherein said electrodes have a size and shape capable of being disposed in the atrium.

44. The apparatus of claim 33 wherein said first electrode has a size and shape capable of being disposed in the right atrium and has means for detecting local electrical signals, and said second electrode has a size and shape capable of being disposed in the coronary sinus proximate to the left atrium and has means for detecting local electrical signals.

45. The apparatus of claim 33 wherein said monitoring means determines when the absolute value of the electrical signal exceeds a sensitivity level to determine the occurrence of an activation.

46. The apparatus of claim 33 wherein said apparatus has a size and shape capable of being implanted in the human body.

47. A method of detecting fibrillation comprising the steps of:

locating two electrodes at two different positions in the heart, each electrode being adapted to sense electrical signals;

monitoring said electrical signals detected by the two electrodes to determine the occurrence of an activation, and after an activation is indicated, said monitoring step further including disregarding the electrical signal for a refractory period before again monitoring the electrical signals;

measuring the time interval between said activations; and

comparing the measured time interval with a reference time interval value and calculating whether the measured time interval substantially deviates from the reference time interval value to thereby ascertain the presence of fibrillation.

48. A method of detecting and treating fibrillation comprising the steps of:

locating two electrodes at two different positions in the heart, each electrode being adapted to sense electrical signals;

monitoring said electrical signals detected by the two electrodes to determine the occurrence of an activation, and after an activation is indicated, said monitoring step further including disregarding the electrical signal for a refractory period before again monitoring the electrical signals;

measuring the time interval between said activations;

comparing the measured time interval with a reference time interval value and calculating whether the measured time interval substantially deviates from the reference time interval value to thereby ascertain the presence of fibrillation; and

if fibrillation is indicated, delivering defibrillation shocks to the heart with the electrodes.

49. An apparatus for use in detecting fibrillation in the atrium, said apparatus comprising:

first and second electrodes capable of being disposed at different locations in the atrium, each of said first and second electrodes having means for detecting local electrical signals in the atrium;

means for monitoring said electrical signals detected by said first and second electrodes to determine the occurrence of an activation, said monitoring means including means for measuring the time interval between said activations; and

means for comparing the measured time interval with a reference time interval value and calculating whether the measured time interval substantially deviates from the reference time interval value, said comparing means including means for indicating the presence of a fibrillation condition in the heart.

50. An apparatus for use in detecting and treating fibrillation in the atrium, said apparatus comprising:

first and second electrodes capable of being disposed at different locations in the atrium, each of said first and second electrodes having means for detecting local electrical signals in the atrium;

means for monitoring said electrical signals detected by said first and second electrodes to determine the occurrence of an activation, said monitoring means including means for measuring the time interval between said electrical activations;

means for comparing the measured time interval with a reference time interval value and calculating whether the measured time interval substantially deviates from the reference time interval value, said comparing means including means for indicating the presence of a fibrillation condition in the heart; and

means for delivering defibrillating shocks to the heart, said defibrillating means being responsive to said indicating means.