Device for treating fine superficial facial lines

• US 5,366,498 A
• Filed: 02/10/1993
• Issued: 11/22/1994
• Est. Priority Date: 03/29/1991
• Status: Expired due to Term

• Current Assignee: Allergan Incorporated (Abbvie Incorporated)
• Original Assignee: Collagen Corp. (Abbvie Incorporated)
• Inventors: Smestad, Thomas L., Fries, Louis, Delustro, Frank A., Brannan, Ann, Burhenne, Roseann, Orland, Rees M.
• Primary Examiner(s): ISABELLA, DAVID J
• Application Number:
  US08/016,490
• Time in Patent Office: 650 Days
• Field of Search: 623/15, 623/11, 604/187, 604/243, 128/DIG. 8
• US Class Current: 623/23.73
• CPC Class Codes: A61F 2/0059 Cosmetic or alloplastic implants A61F2/10 - A61F2/16, A61F2/28 take precedence
• CPC Class Codes: A61F 2310/00365 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61K 2800/87 Application Devices; Containers; Packaging
• CPC Class Codes: A61K 2800/91 Injection
• CPC Class Codes: A61K 8/02 characterised by special physical form
• CPC Class Codes: A61K 8/027 Fibers; Fibrils
• CPC Class Codes: A61K 8/04 Dispersions; Emulsions
• CPC Class Codes: A61K 8/65 Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 31/044 Collagen
• CPC Class Codes: A61M 5/32 Needles; Details of needles pertaining to their connection with syringe or hub infusion needles A61M5/158; Accessories for bringing the needle into, or holding the needle on, the body A61M5/42, A61M5/46 take precedence; guide needles for catheters A61M25/065; Devices for protection of needles apparatus specially adapted for cleaning or sterilising needles A61M5/001
• CPC Class Codes: A61M 5/422 Desensitising skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

A device for correcting fine superficial facial lines which comprises a syringe fitted with a 31-33 gauge needle and an aqueous suspension of noncrosslinked fibrillar atelopeptide collagen contained within the syringe barrel, the concentration of collagen in the suspension being in the range of 10 to 50 mg/ml and the suspension exhibiting an extrusion plot in which there is a smooth substantially linear increase in force up to a substantially constant force in the range of 5 to 30 newtons.

Claims

1. A device for use in correcting fine superficial facial lines comprising:

(a) a syringe having a barrel fitted with a fine gauge needle, the needle having a gauge in the range from 31 to 33, inclusive,

(b) an aqueous suspension of fibrillar noncrosslinked atelopeptide collagen contained within the barrel, the collagen having a concentration in the suspension in the range of 10 to 50 mg/ml, the collagen further being comprised of fibrils of uniform size whereby the uniform size of the fibrils results in improved flow characteristics and enhanced extrudability of the suspension through the fine gauge needle such that the suspension exhibits an extrusion plot in which there is a smooth substantially linear increase in force up to a substantially constant force in the range of 10 to 30 newtons with an average of about 25 newtons.

2. The device of claim 1 wherein said collagen concentration is 30 to 40 mg/ml.

3. The device of claim 1 wherein the needle gauge is 32.

4. The device of claim 2 wherein the needle gauge is 32.

5. The device of claim 4 wherein the barrel has an inner diameter of 4 to 10 mm and the volume of suspension in the barrel is 0.4 to 0.7 cc, inclusive.

6. The device of claim 1 wherein said uniform size fibrils are formed by passing the collagen through a 50 mesh screen.