Sensor arrangement for direct or indirect optical determination of physical or chemical properties

• US 5,368,027 A
• Filed: 04/07/1993
• Issued: 11/29/1994
• Est. Priority Date: 04/23/1992
• Status: Expired due to Fees

• Current Assignee: Avl Medical Instruments AG (Roche Holding AG)
• Original Assignee: Avl Medical Instruments AG (Roche Holding AG)
• Inventors: Karpf, Hellfried, Lubbers, Dietrich W.
• Primary Examiner(s): Sykes, Angela D.
• Application Number:
  US08/043,802
• Time in Patent Office: 601 Days
• Field of Search: 128/633-635, 128/637, 128/664-667, 128/653.4, 128/654, 128/736, 128/636
• US Class Current: 600/345
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/413 Monitoring transplanted tissue or organ, e.g. for possible rejection reactions after a transplant
• CPC Class Codes: A61B 5/42 Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems A61B1/00, A61B5/4857, A61B5/486, A61B5/4866, A61B5/4869 take precedence

Abstract

In a sensor arrangement for direct or indirect optical determination of physical or chemical parameters, in human and animal bodies, the sensor arrangement including an indicator cell which is permeable to the chemical substance or physical quantity to be measured and which contains one or more indicators, a radiation source supplying the excitation radiation for the indicator, and a detector for detection of the response radiation emitted by the indicator, the indicator cell is configured as a capsule which may be introduced into body cavities, such as mouth, nose, stomach, intestine, blood vessels, bronchial tubes, urinary bladder, or which may be implanted in the tissue, and the material used for this capsule is transparent to excitation radiation and to the response radiation emitted by the indicator in the range of wavelengths between 600 and 1,300 nm, and the material of the capsule, or rather, its outer layer, is bio-compatible.

Claims

1. A sensor arrangement for direct or indirect optical determination of physical or chemical parameters, comprising

a radiation source supplying an excitation radiation for at least one indicator, a detector means for detection of a response radiation emitted by said indicator, in which contact between said radiation source and said indicator, and between said indicator and said detector, is exclusively established via said excitation radiation and said response radiation, and an indicator cell which comprises a capsule which is introduceable into body cavities, such as mouth, nose, stomach, intestine, blood vessels, bronchial tubes, urinary bladder, or which is implantable in the tissue, said capsule being permeable to a chemical substance or physical quantity to be measured, and at least one indicator in said capsule, wherein material used for said capsule is transparent to said excitation radiation and to said response radiation in the range of wavelengths between 600 and 1,300 nm, and wherein at least an outer layer of said capsule material is biocompatible.

2. A sensor according to claim 1, wherein said capsule is of essentially one of a spherical, lenticular and cylindrical shape with rounded edges.

3. A sensor arrangement according to claim 2, wherein at least one said capsule is attached on a string.

4. A sensor arrangement according to claim 2, wherein a plurality of said capsules are attached to a two-dimensional network.

5. A sensor arrangement according to claim 1, wherein said capsule is configured as one of a string- and tube-like structure.

6. A sensor arrangement according to claim 1, wherein said capsule is configured as a sheet-like structure.

7. A sensor arrangement according to claim 1, wherein said capsule is sterilizable.

8. A sensor arrangement according to claim 1, wherein said capsule is provided with particles permitting its localization inside the body by one of optical means, ultrasonic techniques, and X-rays.

9. A sensor arrangement according to claim 1, wherein said capsule is provided with at least one reflecting surface which is positioned adjacent to said at least one indicator.

10. A sensor arrangement according to claim 1, wherein said capsule is provided with at least one reflecting surface which is positioned adjacent to a layer containing said indicator.

11. A sensor arrangement according to claim 1, wherein said indicator inside said capsule is embedded in a hydrogel layer.

12. A sensor arrangement according to claim 1, wherein said capsule is made of polymer material transparent in the wave range between 600 and 1,300 nm.

13. A sensor arrangement according to claim 12, wherein said capsule is made of a dialytic membrane.

14. A sensor arrangement according to claim 1, wherein said capsule is made of glass transparent in the wave range between 600 and 1,300 nm.

15. A sensor arrangement according to claim 1, wherein said at least one indicator in said capsule is provided for measuring at least one physical or chemical parameter from a group consisting of ionic concentration, partial gas pressure, concentration of enzyme or substrate, ionic strength, pressure, and temperature.