Magnetic resonance surgery using heat waves produced with a laser fiber

• US 5,368,031 A
• Filed: 09/24/1993
• Issued: 11/29/1994
• Est. Priority Date: 08/29/1993
• Status: Expired due to Term

• Current Assignee: InSightec Ltd.
• Original Assignee: General Electric Company
• Inventors: Anthony, Thomas R., Cline, Harvey E.
• Primary Examiner(s): Pfaffle, K. M.
• Application Number:
  US08/125,520
• Time in Patent Office: 431 Days
• Field of Search: 128/653.1, 128/653.2, 128/653.5, 606/15, 606/28, 606/31, 607/88-89, 607/92, 607/96, 607/100, 607/102, 607/113
• US Class Current: 600/411
• CPC Class Codes: A61B 18/22 the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
• CPC Class Codes: A61B 2017/00154 pulsed
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: G01R 33/4804 Spatially selective measurement of temperature or pH
• CPC Class Codes: G01R 33/561 by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
• CPC Class Codes: G01R 33/56341 Diffusion imaging

Abstract

Surgery is performed with pulsed heat means that selectively destroys tissue in a region within a patient. The size of the region destroyed is dependent upon the frequency of the pulses of the pulsed heat means and thermal conductivity of the tissue of the patient. The pulsed heat means can be a coherent optical source that is guided by laser fiber to the tissue to be destroyed. In another embodiment the pulsed heat means is a focussed ultrasound transducer that dissipates ultrasonic energy at a focal point within the region of tissue to be destroyed. A magnetic resonance imaging system employing a temperature sensitive pulse sequence creates an image of the tissue and the region being heated to allow a surgeon to alter the position of the pulsed heat means or vary the pulse frequency.

Claims

1. A magnetic resonance (MR) surgery system that comprises:

a) an invasive device having a tip adapted for being inserted into a patient, the invasive device capable of transmitting optical energy at an application point proximate to the tip;

b) an optical source for applying heat waves by pulsing optical energy through the tip of the invasive device at a frequency f and amplitude Q at the application point to create a heated region having a temperature distribution T(r,t) around the application point described by;

space="preserve" listing-type="equation">T(r,t)=Q/ρ

c Exp[-kr]cos(2π

ft-kr)/r [4]

where Q is the amplitude of heat provided;

r is the radius from the center of the heated region;

t is time;

ρ

is density of the heated region;

c is specific heat of the heated region; and

k=Sqrt (ω

/2D), where D is the thermal diffusity of the tissue in the heated region;

c) MR compatible positioning means, connected to the invasive device, for positioning the tip of the invasive device such that the application point is positioned to cause a selected tissue within the patient to have the desired temperature distribution T(r,t);

d) an MR imaging means adapted for creating fast scan MR images of the temperature distribution T(r,t) around the application point during surgery using a temperature sensitive pulse sequence; and

e) display means, coupled to the MR imaging means, for interactively displaying the temperature sensitive images to an operator to allow the operator to control the temperature distribution T(r,t).

2. The MR surgery system of claim 1 wherein the optical source comprises a laser.

3. A method of performing heat surgery on a patient, as guided by a magnetic resonance (MR) imaging apparatus capable of producing temperature sensitive MR images, comprising the steps of;

a) determining a position of a selected tissue to be destroyed in said patient with said MR imaging apparatus,

b) positioning a tip of an optical fiber at an application point near the selected tissue within said patient;

c) determining a desired temperature distribution T(r,t);

d) pulsing optical energy at a frequency f and amplitude Q in order to create a heated region having the desired temperature distribution around the application point, such that;

space="preserve" listing-type="equation">T(r,t)=Q/ρ

c Exp[-kr]cos(2π

ft-kr)/r [4]

where Q is the amplitude of heat provided;

r is the radius from the center of the heated region;

t is time;

ρ

is density of the heated region;

c is specific heat of the heated region; and

k=Sqrt (ω

/2D), where D is the thermal diffusity of the tissue in the heated region;

e) monitoring the temperature distribution T(r,t) with said MR imaging apparatus; and

f) adjusting the frequency f, the amplitude Q and the location of the application point.